Critical Care Evidence Updates – May 2023

Randomised Controlled Trials

Acute traumatic coma awakening by right median nerve electrical stimulation: a randomised controlled trial  Intensive Care Medicine

Comparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 DiabetesThe GRADE Randomized Clinical Trial  JAMA Internal Medicine

Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With SepsisThe EXIT-SEP Randomized Clinical Trial  JAMA Internal Medicine

Effect of P2Y12 Inhibitors on Organ Support–Free Survival in Critically Ill Patients Hospitalized for COVID-19  –  A Randomized Clinical Trial  JAMA Network Open

Efficacy and safety of sulbactam–durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii–calcoaceticus complex: a multicentre, randomised, active-controlled, phase 3, non-inferiority clinical trial (ATTACK)  The Lancet Infectious Diseases

Efficacy of prolonged intravenous lidocaine infusion for postoperative movement-evoked pain following hepatectomy: a double-blinded, randomised, placebo-controlled trial  British Journal of Anaesthesia

High-flow oxygen therapy versus facemask preoxygenation in anticipated difficult airway management (PREOPTI-DAM): an open-label, single-centre, randomised controlled phase 3 trial  eClinicalMedicine

Long-term outcome of COVID-19 patients treated with helmet noninvasive ventilation vs. high-flow nasal oxygen: a randomized trial  Journal of Intensive Care

Respective Effects of Helmet Pressure Support, Continuous Positive Airway Pressure, and Nasal High-Flow in Hypoxemic Respiratory Failure: A Randomized Crossover Clinical Trial  American Journal of Respiratory and Critical Care Medicine

Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trial  The Lancet Respiratory Medicine

Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial): A Multicentre, Randomised, Controlled Trial  American Journal of Respiratory and Critical Care Medicine

Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial  Critical Care

Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion  NEJM

Under-The-Nose Versus Over-The-Nose Face Mask to Prevent Facial Pressure Sores During Face Mask-Delivered Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure: A Randomized Controlled Trial  Critical Care Medicine

Videolaryngoscopy vs. flexible fibrescopy for tracheal intubation in patients with cervical spine immobilisation: a randomised controlled trial  Anaesthesia


Head injury: assessment and early management NG232

Intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure from high spinal cord injuries IPG762

Point-of-care tests for urinary tract infections to improve antimicrobial prescribing: early value assessment HTE7

Other Guidance/Reports

2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association  Stroke

A brain-based definition of death and criteria for its determination after arrest of circulation or neurologic function in Canada: a 2023 clinical practice guideline  Canadian Journal of Anesthesia

Adult Cardiac Surgery Associated Acute Kidney Injury: Joint Consensus Report of the PeriOperative Quality Initiative (POQI) and the Enhanced Recovery After Surgery (ERAS®) Cardiac Society  Journal of Cardiothoracic and Vascular Anesthesia

Cardiac arrest in the perioperative period: a consensus guideline for identification, treatment, and prevention from the European Society of Anaesthesiology and Intensive Care and the European Society for Trauma and Emergency Surgery  European Journal of Anaesthesiology

Cognitive Impairment After Ischemic and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association/American Stroke Association  Stroke

Continuous electroencephalography in the intensive care unit: A critical review and position statement from an Australian and New Zealand perspective  Critical Care Resuscitation

Expert consensus statement on venovenous extracorporeal membrane oxygenation ECMO for COVID-19 severe ARDS: an international Delphi study  Annals of Intensive Care

Guidelines for the Neurocritical Care Management of Aneurysmal Subarachnoid Hemorrhage  Neurocritical Care

ISTH guidelines for antithrombotic treatment in COVID-19: Endorsement by the Scandinavian Society of Anaesthesiology and Intensive Care Medicine  Acta Anaesthesiologica Scandinavica

New-onset atrial fibrillation in critically ill adult patients—an SSAI clinical practice guideline  Acta Anaesthesiologica Scandinavica

Organ donation in the surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document  Trauma surgery & Acute Care Open

Organ and Tissue Donation Consent Model and Intent to Donate Registries: Recommendations From an International Consensus Forum  Transplantation Direct

Physical rehabilitation in the intensive care unit: past, present, and future  Intensive Care Medicine

Rationale and clinical application of antimicrobial stewardship principles in the intensive care unit: a multidisciplinary statement  Journal of Anesthesia, Analgesia and Critical Care

Research and Innovation in Organ Donation: Recommendations From an International Consensus Forum  Transplantation Direct

Research Bronchoscopies in Critically Ill Research Participants: An Official American Thoracic Society Workshop Report  Annals of the American Thoracic Society

SCAI Expert Consensus Statement on Management of In-Stent Restenosis and Stent Thrombosis  JSCAI

Targeted temperature management in patients with intracerebral haemorrhage, subarachnoid haemorrhage, or acute ischaemic stroke: updated consensus guideline recommendations by the Neuroprotective Therapy Consensus Review (NTCR) group  British Journal of Anaesthesia

‘Tea trolley’ difficult airway teaching 2022: A new spin on an old idea  Anaesthesia and Intensive Care

The 2023 International Society for Heart and Lung Transplantation Guidelines for Mechanical Circulatory Support: A 10- Year Update  The Journal of Heart and Lung Transplantation

What’s new in therapeutic drug monitoring of antimicrobials?  Intensive Care Medicine


Family presence during resuscitation

Primary Research

A deep learning model enables accurate prediction and quantification of pulmonary edema from chest X-rays  Critical Care

An International, Multicenter Evaluation of Comprehensive Medication Management by Pharmacists in ICU Recovery Centers  Journal of Intensive Care Medicine

Association between combination antibiotic therapy as opposed as monotherapy and outcomes of ICU patients with Pseudomonas aeruginosa ventilator-associated pneumonia: an ancillary study of the iDIAPASON trial  Critical Care

Association Between Vaccination Status and Outcomes in Patients Admitted to the ICU With COVID-19  Critical Care Medicine

Association of blood viscosity and device-free days among hospitalized patients with COVID-19  Journal of Intensive Care

Biomarker-Concordant Steroid Administration in Severe Coronavirus Disease-2019  Journal of Intensive Care Medicine

Characteristics and Outcomes of Very Elderly Patients Admitted to Intensive Care: A Retrospective Multicenter Cohort Analysis  Critical Care Medicine

Clinical Outcomes of Intensive Inpatient Blood Pressure Management in Hospitalized Older Adults  JAMA Internal Medicine

Critically-ill patients with acute kidney injury: clinical determinants and post-mortem histology  Clinical Kidney Journal

Decreased Utilization of Low Tidal Volume Ventilation Outside of the Intensive Care Unit as Compared to Inside  Journal of Intensive Care Medicine

Discharge Disposition and Loss of Independence Among Survivors of COVID-19 Admitted to Intensive Care: Results From the SCCM Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS)  Journal of Intensive Care Medicine

Dual titration of minute ventilation and sweep gas flow to control carbon dioxide variations in patients on venovenous extracorporeal membrane oxygenation  Annals of Intensive Care

Early Empiric Antibiotic Use in Patients Hospitalized With COVID-19: A Retrospective Cohort Study  Critical Care Medicine

Effects of Etomidate on Postintubation Hypotension, Inflammatory Markers, and Mortality in Critically Ill Patients with COVID-19: An International, Multicenter, Retrospective Study  Journal of Intensive Care Medicine

Efficacy of Carbapenems Compared With Noncarbapenem Broad-Spectrum Beta-Lactam Antibiotics as Initial Antibiotic Therapy Against Sepsis: A Nationwide Observational Study  Critical Care Medicine

High-Dose Steroids for Nonresolving Acute Respiratory Distress Syndrome in Critically Ill COVID-19 Patients Treated With Dexamethasone: A Multicenter Cohort Study  Critical Care Medicine

Identification of an optimal threshold to define oliguria in critically ill patients: an observational study  Critical Care

Impact of macrolide treatment on long-term mortality in patients admitted to the ICU due to CAP: a targeted maximum likelihood estimation and survival analysis  Critical Care

Initial 24-h perfusion index of ICU admission is associated with acute kidney injury in perioperative critically ill patients: A retrospective cohort analysis  Journal of Intensive Medicine

Initiating angiotensin II at lower vasopressor doses in vasodilatory shock: an exploratory post-hoc analysis of the ATHOS-3 clinical trial  Critical Care

Lower versus higher oxygenation targets in hypoxaemic ICU patients after cardiac arrest  Resuscitation

Mechanical Power Delivered by Noninvasive Ventilation Contributes to Physio-Anatomical and Clinical Responses to Early Versus Late Proning in COVID-19 Pneumonia  Critical Care Medicine

Noninvasive Monitoring of Arterial Pressure: Finger or Lower Leg As Alternatives to the Upper Arm: A Prospective Study in Three ICUs  Critical Care Medicine

Pharmacophenotype identification of intensive care unit medications using unsupervised cluster analysis of the ICURx common data model  Critical Care

Prolonged use of intravenous administration sets on central line associated bloodstream infection, nursing workload and material use: A before-after study  Intensive and Critical Care Nursing

Prospective Evaluation of a Dynamic Acuity Score for Regularly Assessing a Critically Ill Patient’s Risk of Mortality  Critical Care Medicine

Sodium glucose co-transporter-2 inhibitors in intensive care unit patients with type 2 diabetes: a pilot case control study  Critical Care

Stomach position evaluated using computed tomography is related to successful post-pyloric enteral feeding tube placement in critically ill patients: a retrospective observational study  Journal of Intensive Care

Temporal relationship between vasopressor and sedative administration and cerebrovascular response in traumatic brain injury: a time-series analysis  Intensive Care Medicine Experimental

The association between the presence and burden of periodic discharges and outcome in septic patients: an observational prospective study  Critical Care

The impact of a preoperative nurse-led orientation program on postoperative delirium after cardiovascular surgery: a retrospective single-center observational study  Journal of Intensive Care

The lower limit of reactivity as a potential individualised cerebral perfusion pressure target in traumatic brain injury: a CENTER-TBI high-resolution sub-study analysis  Critical Care

The Two-Bag Method for Management of Adult Diabetic Ketoacidosis—Experience With 634 Patients  Journal of Intensive Care Medicine

Variable Levels of Oxytocin During Sepsis: The Role of Oxytocin in Sepsis Pathophysiology  Journal of Intensive Care Medicine


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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