Critical Care Evidence Updates – November 2021


CerebAir for continuous EEG monitoring in intensive care – medtech innovation briefing (MIB279)

COVID-19 rapid guideline: managing COVID-19 NG191

COVID-19 rapid guideline: managing the long-term effects of COVID-19 NG188

Other Guidance/Reports

2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations Resuscitation

Antimicrobial stewardship interventions: a practical guide (2021) (PDF) WHO Europe

Coronavirus (COVID-19): guidance on critical care management of adult patients Updated 16 November 2021 Scottish Government

Coronavirus (COVID-19) Infection in Pregnancy: Information for healthcare professionals Version 14.1: updated 02/11/2021 (PDF) RCOG and RCM

ERS Clinical Practice Guidelines: high-flow nasal cannula in acute respiratory failure European Respiratory Society

Resuscitation Council UK Statement on COVID-19 in relation to CPR and resuscitation for those teaching resuscitation techniques: updated 1/09/2021 Resuscitation Council

Treating COVID-19 patients using continuous positive airway pressure (CPAP) outside of a critical care unit Healthcare Safety Investigation Branch


Antibiotics for hospital‐acquired pneumonia in neonates and children

Antiepileptic drugs for seizure control in people with neurocysticercosis

Early warning systems and rapid response systems for the prevention of patient deterioration on acute adult hospital wards

Interventions for altering blood pressure in people with acute subarachnoid haemorrhage

Non‐corticosteroid adjuvant therapies for acute bacterial meningitis

Non‐pharmacological interventions for preventing delirium in hospitalised non‐ICU patients

Reducing medication errors for adults in hospital settings

Vitamin C supplementation for prevention and treatment of pneumonia

Systematic Reviews from Other Sources

Artificial intelligence for mechanical ventilation: systematic review of design, reporting standards, and bias. British Journal of Anaesthesia

Clinical efficacy and safety of interferon-β-containing regimens in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials. Expert Review of Anti-Infective Therapy

Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis Journal of Intensive Care

Effect of famotidine on hospitalized patients with COVID-19: A systematic review and meta-analysis PloS One

Effect of Patient and Family Centred Care interventions for adult intensive care unit patients and their families: A systematic review and meta-analysis. Intensive & Critical Care Nursing

Effect of Premorbid Beta-Blockers on Mortality in Patients With Sepsis: A Systematic Review and Meta-Analysis Journal of Intensive Care Medicine

Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis Critical Care

Effectiveness and safety of SARS-CoV-2 vaccine in real-world studies: a systematic review and meta-analysis. Infectious Diseases of Poverty

Efficacy of non-invasive and invasive respiratory management strategies in adult patients with acute hypoxaemic respiratory failure: a systematic review and network meta-analysis Critical Care

Global epidemiological burden of fungal infections in cirrhosis patients: a systematic review with meta-analysis. Mycoses

Hospital-acquired infections caused by enterococci: a systematic review and meta-analysis, WHO European Region, 1 January 2010 to 4 February 2020. Euro Surveillance

Interventions to promote oral care regimen adherence in the critical care setting: A systematic review. Australian Critical Care

Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis Intensive Care Medicine

Nursing interventions to cover patients’ basic needs in the intensive care context – A systematic review. Nursing Open

Prediction of extubation outcome in critically ill patients: a systematic review and meta-analysis. Critical Care

Steroid treatment in patients with acute respiratory distress syndrome: a systematic review and network meta-analysis. Journal of Anesthesia

Primary Research

A pilot, feasibility, randomised controlled trial of midodrine as adjunctive vasopressor for low-dose vasopressor-dependent hypotension in intensive care patients: The MAVERIC study Journal of Critical Care

A Randomized Trial of Intravenous Alteplase before Endovascular Treatment for Stroke NEJM

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction NEJM

Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial The Lancet

Aspirin as a Treatment for Acute Respiratory Distress Syndrome: a randomised placebo controlled clinical trial. Chest

Background frequency can enhance the prognostication power of EEG patterns categories in comatose cardiac arrest survivors: a prospective, multicenter, observational cohort study Critical Care

Cardiovascular Nurses’ Experiences Of Working In The Covid-19 Intensive Care Unit: A Qualitative Study Intensive and Critical Care Nursing

Causes of acute respiratory failure in patients with small-vessel vasculitis admitted to intensive care units: a multicenter retrospective study Annals of Intensive Care

Changes in intensive care unit nurse involvement in end of life decision making between 1999 and 2016: Descriptive comparative study Intensive and Critical Care Nursing

Comparison of Two Extubation Techniques in Critically Ill Adult Subjects: The ExtubAR Randomized Clinical Trial Respiratory Care

Corticosteroid treatment and mortality in mechanically ventilated COVID-19-associated acute respiratory distress syndrome (ARDS) patients: a multicentre cohort study Annals of Intensive Care

Critical care nurses’ experiences of working during the first phase of the COVID-19 pandemic –Applying the Person-centred Practice Framework Intensive and Critical Care Nursing

Development and evaluation of the focused assessment of sonographic pathologies in the intensive care unit (FASP-ICU) protocol Critical Care

Development of a comprehensive model for the role of the rapid response team nurse Intensive and Critical Care Nursing

Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxaemia: a pre-planned, secondary Bayesian analysis of the COVID STEROID 2 trial Intensive Care Medicine

Diffuse aspergillosis in a patient with SARS-CoV-2 pneumonia Intensive Care Medicine

Early prediction of hemodynamic interventions in the intensive care unit using machine learning Critical Care

Effect of antibiotic therapy on the prognosis of ventilator-associated pneumonia caused by Stenotrophomonas maltophilia Annals of Intensive Care

End of life in the critically ill patient: evaluation of experience of end of life by caregivers (EOLE study) Annals of Intensive Care

Exploring medical device-related pressure injuries in a single intensive care setting: A longitudinal point prevalence study Intensive and Critical Care Nursing

Feasibility of early waking cardiac arrest patients whilst receiving therapeutic hypothermia: The therapeutic hypothermia and early waking (THAW) trial Resuscitation

Five-Year Outcomes After Implementing a Pain, Agitation, and Delirium Protocol in a Mixed Intensive Care Unit Journal of Intensive Care Medicine

GFAp and tau protein as predictors of neurological outcome after out-of-hospital cardiac arrest: a post hoc analysis of the COMACARE trial Resuscitation

Higher levels of IgA and IgG at sepsis onset are associated with higher mortality: results from the Albumin Italian Outcome Sepsis (ALBIOS) trial Annals of Intensive Care

Hypertriglyceridemia Induced Pancreatitis: plasmapheresis or conservative management? Journal of Intensive Care medicine

Immune Profiling Demonstrates a Common Immune Signature of Delayed Acquired Immunodeficiency in Patients With Various Etiologies of Severe Injury Critical Care Medicine

Impact of cooling method on the outcome of initial shockable or non-shockable out of hospital cardiac arrest patients receiving target temperature management: a nationwide multicentre cohort study Annals of Intensive Care

Impact of COVID-19 on nursing workload as measured with the Nursing Activities Score in intensive care: summary of findings Intensive and Critical Care Nursing

Impact of obesity on survival in COVID-19 ARDS patients receiving ECMO: results from an ambispective observational cohort Annals of Intensive Care

Impact of Underlying Congestive Heart Failure on In-Hospital Outcomes in Patients with Septic Shock Journal of Intensive Care Medicine

Incidence, clinical characteristics, and outcome after unexpected cardiac arrest among critically ill adults with COVID-19: insight from the multicenter prospective ACICOVID-19 registry Annals of Intensive Care

Inhaled Pulmonary Vasodilator Therapy in Adult Lung Transplant A Randomized Clinical Trial JAMA Surgery

Initial Derivation of a Predictive Model for Left Ventricular Longitudinal Strain (LS) in Early Sepsis Journal of Intensive Care Medicine

Insights into the challenges faced by chronically critically ill patients, their families and healthcare providers: An interpretive description Intensive and Critical Care Nursing

Intravenous immunoglobulins in patients with COVID-19-associated moderate-to-severe acute respiratory distress syndrome (ICAR): multicentre, double-blind, placebo-controlled, phase 3 trial The Lancet Respiratory Medicine

Is Ventilator-Associated Pneumonia More Frequent in Patients With Coronavirus Disease 2019? Critical Care Medicine. Editorial

Long-term survival and health-related quality of life in patients with severe acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation support Critical Care

Mannitol is comparable to hypertonic saline for raised intracranial pressure in Acute Liver Failure (MAHAL Study): A RCT Digestive Diseases

Mechanisms of oxygenation responses to proning and recruitment in COVID-19 pneumonia Intensive Care Medicine

Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS Critical Care

Non-invasive detection of a femoral-to-radial arterial pressure gradient in intensive care patients with vasoactive agents Journal of Intensive Care

Optimizing cerebral oxygen delivery after cardiac arrest: A role for neuromonitoring Resuscitation

Optimizing high-flow nasal cannula flow settings in adult hypoxemic patients based on peak inspiratory flow during tidal breathing Annals of Intensive Care

Outcomes of Critically Ill Lung Cancer Patients Initiating Targeted Therapy or Immunotherapy in the Intensive Care Unit: A Single-Center Report Journal of Intensive Care Medicine

Predictors of poor outcome after extra-corporeal membrane oxygenation for refractory cardiac arrest (ECPR): A post hoc analysis of a multicenter database Resuscitation

Peripheral microcirculatory alterations are associated with the severity of acute respiratory distress syndrome in COVID-19 patients admitted to intermediate respiratory and intensive care units Critical Care

Prostacyclin in Mechanically Ventilated Patients with COVID-19 and Severe Endotheliopathy: A Multicenter, Randomized, Clinical Trial American Journal of Respiratory and Critical Care Medicine

Rapidly progressive brain atrophy in septic ICU patients: a retrospective descriptive study using semiautomatic CT volumetry Critical Care

Reactivation of EBV and CMV in Severe COVID-19—Epiphenomena or Trigger of Hyperinflammation in Need of Treatment? A Large Case Series of Critically ill Patients Journal of Intensive Care Medicine

Safety and efficacy of multipotent adult progenitor cells in acute respiratory distress syndrome (MUST-ARDS): a multicentre, randomised, double-blind, placebo-controlled phase 1/2 trial Intensive Care Medicine

Self-perceived recovery and quality of life in elderly patients surviving ICU-admission for abdominal sepsis Journal of Intensive Care Medicine

Shock Index, Modified Shock Index and MELD as Predictors of Mortality for Critically Ill Patients With Liver Disease Journal of Intensive Care Medicine

The Effectiveness of Motivational Messages to ICU Nurses during the COVID-19 Pandemic Intensive and Critical Care Nursing

The inflammatory response is related to circulatory failure after out-of-hospital cardiac arrest: A prospective cohort study Resuscitation

The obesity paradox and hypoglycemia in critically ill patients Critical Care

The effect of the COVID-19 pandemic on the epidemiology of positive blood cultures in Swiss intensive care units: a nationwide surveillance study Critical Care

The Role of Inhaled Corticosteroids (ICS) in Critically Ill Patients With COVID-19: A Multicenter, Cohort Study Journal of Intensive Care Medicine

Thrombosis and Bleeding After Implementation of an Intermediate-Dose Prophylactic Anticoagulation Protocol in ICU Patients With COVID-19: A Multicenter Screening Study Journal of Intensive Care Medicine


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date: 16th December 2021
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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