Critical Care Evidence Updates – November 2022

Randomised Controlled Trials

A randomised pilot feasibility study of eye movement desensitisation and reprocessing recent traumatic episode protocol, to improve psychological recovery following intensive care admission for COVID-19  Journal of the Intensive Care Society

An Enhanced Strategy for Daily Disinfection in Acute Care Hospital Rooms A Randomized Clinical Trial  – JAMA Network Open

Astegolimab or Efmarodocokin Alfa in Patients With Severe COVID-19 Pneumonia: A Randomized, Phase 2 Trial  – Critical Care Medicine

Bivalirudin plus a high-dose infusion versus heparin monotherapy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a randomised trial  – The Lancet

Comparison of Different Tidal Volumes for Ventilation in Patients with an Acute Traumatic Cervical Spine Injury  – Neurology India

Defibrillation Strategies for Refractory Ventricular Fibrillation  – NEJM

Duration of Device-Based Fever Prevention after Cardiac Arrest  – NEJM

Early administration of tofacitinib in COVID-19 pneumonitis: An open randomised controlled trial – European Journal of Clinical Investigation

Effect of an enteral amino acid blend on muscle and gut functionality in critically ill patients: a proof-of-concept randomized controlled trial  – Critical Care

Effect of postextubation noninvasive ventilation with active humidification vs high-flow nasal cannula on reintubation in patients at very high risk for extubation failure: a randomized trial  – Intensive Care Medicine

Efficacy of Levosimendan in the Treatment of Patients With Severe Septic Cardiomyopathy  – Journal of Cardiothoracic and Vascular Anesthesia

Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock: Results of the ECMO-CS Randomized Clinical Trial  – Circulation

Fluid balance and renal replacement therapy initiation strategy: a secondary analysis of the STARRT-AKI trial  – Critical Care

Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial  – The Lancet

Long-Term Outcome of Severe Metabolic Acidemia in ICU Patients, a BICAR-ICU Trial Post Hoc Analysis  – Critical Care Medicine

Nebulized versus intravenous tranexamic acid for hemoptysis: A pilot randomized controlled trial  – Chest

Predictive factors for severe long-term chronic kidney disease after acute kidney injury requiring renal replacement therapy in critically ill patients: an ancillary study of the ELVIS randomized controlled trial  – Critical Care

Prevention of alcohol withdrawal syndrome in the surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document  – Trauma Surgery & Acute Care Open

Prolonged higher dose methylprednisolone vs. conventional dexamethasone in COVID-19 pneumonia: a randomised controlled trial (MEDEAS)  – European Respiratory Journal

Reduce the risk of ventilator-associated pneumonia in ICU patients by Ozonated water mouthwash: A double-blind randomized clinical trial  – American Journal of Infection Control

Respective Effects of Helmet Pressure Support, Continuous Positive Airway Pressure and Nasal High-Flow in Hypoxemic Respiratory Failure: A Randomized Crossover Clinical Trial  – American Journal of Respiratory and Critical Care Medicine

Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial  – Critical Care

Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial  – Critical Care

The effects of external diaphragmatic pacing on diaphragm function and weaning outcomes of critically ill patients with mechanical ventilation: a prospective randomized study  – Annals of Translational Medicine


Subarachnoid haemorrhage caused by a ruptured aneurysm: diagnosis and management NG228

Tunnelled peritoneal drainage catheter insertion for refractory ascites in cirrhosis IPG746

Other Guidance/Reports

Management of hypertensive crisis: British and Irish Hypertension Society Position document  – Journal of Human Hypertension

The revised recommendation for administering vitamin C in septic patients: the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020  – Journal of Intensive Care


Antibody tests for identification of current and past infection with SARS‐CoV‐2

Exercise for acutely hospitalised older medical patients

Prothrombin complex concentrate in cardiac surgery for the treatment of coagulopathic bleeding

Timing of kidney replacement therapy initiation for acute kidney injury

Primary Research

A genome-wide association study of survival in patients with sepsis  – Critical Care

A Simplified Electroencephalography Montage and Interpretation for Evaluation of Comatose Patients in the ICU  – Critical Care Explorations

A universal predictive and mechanistic urinary peptide signature in acute kidney injury  – Critical Care

Accuracy of a Risk Alert Threshold for ICU Hypoglycemia: Retrospective Analysis of Alert Performance and Association With Clinical Deterioration Events  – Critical Care Medicine

Association between frailty, delirium, and mortality in older critically ill patients: a binational registry study  – Annals of Intensive Care

Catheter-associated urinary tract infections in the ICU: Why we still should care  – Intensive and Critical Care Nursing

Chest wall loading in the ICU: pushes, weights, and positions  – Annals of Intensive Care

Clinical course and outcomes of cancer patients admitted in medical ICU with sepsis  – Journal of the Intensive Care Society

Clinical outcome of wild-type AmpC-producing Enterobacterales infection in critically ill patients treated with β-lactams: a prospective multicenter study  – Annals of Intensive Care

Continuous prolonged prone positioning in COVID-19-related ARDS: a multicenter cohort study from Chile  – Annals of Intensive Care

Correlation between the hysteresis of the pressure–volume curve and the recruitment-to-inflation ratio in patients with coronavirus disease 2019  – Annals of Intensive Care

Corticotropin-stimulated steroid profiles to predict shock development and mortality in sepsis: From the HYPRESS study  – Critical Care

Critical Care and Postoperative Management of the First Human Long Segment Orthotopic Tracheal Transplantation  – Critical Care Explorations

Effect of Enteral Guanfacine on Dexmedetomidine Use in the ICU  – Critical Care Explorations

Effect of high-flow nasal cannula therapy on thirst sensation and dry mouth after extubation: A single-centre prospective cohort study  – Intensive and Critical Care Nursing

Electrical impedance tomography for titration of positive end-expiratory pressure in acute respiratory distress syndrome patients with chronic obstructive pulmonary disease  – Critical Care

Family member perspectives on intensive care unit in-person visiting restrictions during the COVID-19 pandemic: A qualitative study  – Intensive and Critical Care Nursing

Flow generators for helmet CPAP: Which to prefer? A bench study  – Intensive and Critical Care Nursing

Hemoglobin Concentration Impacts Viscoelastic Hemostatic Assays in ICU Admitted Patients  – Critical Care Medicine

Impact of Prone Position in COVID-19 Patients on Extracorporeal Membrane Oxygenation  – Critical Care Medicine

Impact of secondary sepsis on mortality in adult intensive care unit patients  – Intensive and Critical Care Nursing

Incidence and Outcomes of Patients Receiving Chronic Kidney Replacement Therapy Admitted to Scottish ICUs Between 2009 and 2019—A National Observational Cohort Study  – Critical Care Medicine

Latent class analysis of imaging and clinical respiratory parameters from patients with COVID-19-related ARDS identifies recruitment subphenotypes  – Critical Care

Longitudinal phenotypes in patients with acute respiratory distress syndrome: a multi-database study  – Critical Care

Multistate Modeling of Clinical Trajectories and Outcomes in the ICU: A Proof-of-Concept Evaluation of Acute Kidney Injury Among Critically Ill Patients With COVID-19  – Critical Care Explorations

Mobilisation of critically ill patients receiving norepinephrine: a retrospective cohort study  – Critical Care

One hundred ECMO retrivals before and during the Covid-19 pandemic: an observational study  – Intensive and Critical Care Nursing

Outcomes of Patients With Sepsis and Septic Shock Requiring Source Control: A Prospective Observational Single-Center Study  – Critical Care Explorations

Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation  – NEJM

Right ventricular free wall longitudinal strain is independently associated with mortality in mechanically ventilated patients with COVID-19  – Annals of Intensive Care

Spontaneous pneumomediastinum: a surrogate of P-SILI in critically ill COVID-19 patients  – Critical Care

Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients  – Critical Care

The characteristics and factors associated with omitted nursing care in the intensive care unit: A cross-sectional study  – Intensive and Critical Care Nursing

The Intensive Care Unit diary — A significant complement in the recovery after intensive care. A focus group study  – Intensive and Critical Care Nursing

Timing of dialysis in acute kidney injury using routinely collected data and dynamic treatment regimes  – Critical Care

Timing of Prone Positioning During Venovenous Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome  – Critical Care Medicine

Trajectories of Palliative Care Needs in the ICU and Long-Term Psychological Distress Symptoms  – Critical Care Medicine

Use of an innovative cuff pressure control and subglottic secretions drainage system in COVID-19 ARDS patients undergoing pronation  – Critical Care


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date: 6th December 2022
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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