Critical Care Evidence Updates – November 2022
Randomised Controlled Trials
A randomised pilot feasibility study of eye movement desensitisation and reprocessing recent traumatic episode protocol, to improve psychological recovery following intensive care admission for COVID-19 Journal of the Intensive Care Society
Astegolimab or Efmarodocokin Alfa in Patients With Severe COVID-19 Pneumonia: A Randomized, Phase 2 Trial – Critical Care Medicine
Comparison of Different Tidal Volumes for Ventilation in Patients with an Acute Traumatic Cervical Spine Injury – Neurology India
Defibrillation Strategies for Refractory Ventricular Fibrillation – NEJM
Duration of Device-Based Fever Prevention after Cardiac Arrest – NEJM
Early administration of tofacitinib in COVID-19 pneumonitis: An open randomised controlled trial – European Journal of Clinical Investigation
Effect of an enteral amino acid blend on muscle and gut functionality in critically ill patients: a proof-of-concept randomized controlled trial – Critical Care
Effect of postextubation noninvasive ventilation with active humidification vs high-flow nasal cannula on reintubation in patients at very high risk for extubation failure: a randomized trial – Intensive Care Medicine
Efficacy of Levosimendan in the Treatment of Patients With Severe Septic Cardiomyopathy – Journal of Cardiothoracic and Vascular Anesthesia
Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock: Results of the ECMO-CS Randomized Clinical Trial – Circulation
Fluid balance and renal replacement therapy initiation strategy: a secondary analysis of the STARRT-AKI trial – Critical Care
Long-Term Outcome of Severe Metabolic Acidemia in ICU Patients, a BICAR-ICU Trial Post Hoc Analysis – Critical Care Medicine
Nebulized versus intravenous tranexamic acid for hemoptysis: A pilot randomized controlled trial – Chest
Prevention of alcohol withdrawal syndrome in the surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee Clinical Consensus Document – Trauma Surgery & Acute Care Open
Prolonged higher dose methylprednisolone vs. conventional dexamethasone in COVID-19 pneumonia: a randomised controlled trial (MEDEAS) – European Respiratory Journal
Reduce the risk of ventilator-associated pneumonia in ICU patients by Ozonated water mouthwash: A double-blind randomized clinical trial – American Journal of Infection Control
Respective Effects of Helmet Pressure Support, Continuous Positive Airway Pressure and Nasal High-Flow in Hypoxemic Respiratory Failure: A Randomized Crossover Clinical Trial – American Journal of Respiratory and Critical Care Medicine
Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial – Critical Care
The effects of external diaphragmatic pacing on diaphragm function and weaning outcomes of critically ill patients with mechanical ventilation: a prospective randomized study – Annals of Translational Medicine
NICE
Subarachnoid haemorrhage caused by a ruptured aneurysm: diagnosis and management NG228
Tunnelled peritoneal drainage catheter insertion for refractory ascites in cirrhosis IPG746
Other Guidance/Reports
Management of hypertensive crisis: British and Irish Hypertension Society Position document – Journal of Human Hypertension
The revised recommendation for administering vitamin C in septic patients: the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 – Journal of Intensive Care
Cochrane
Antibody tests for identification of current and past infection with SARS‐CoV‐2
Exercise for acutely hospitalised older medical patients
Prothrombin complex concentrate in cardiac surgery for the treatment of coagulopathic bleeding
Timing of kidney replacement therapy initiation for acute kidney injury
Primary Research
A genome-wide association study of survival in patients with sepsis – Critical Care
A Simplified Electroencephalography Montage and Interpretation for Evaluation of Comatose Patients in the ICU – Critical Care Explorations
A universal predictive and mechanistic urinary peptide signature in acute kidney injury – Critical Care
Accuracy of a Risk Alert Threshold for ICU Hypoglycemia: Retrospective Analysis of Alert Performance and Association With Clinical Deterioration Events – Critical Care Medicine
Association between frailty, delirium, and mortality in older critically ill patients: a binational registry study – Annals of Intensive Care
Catheter-associated urinary tract infections in the ICU: Why we still should care – Intensive and Critical Care Nursing
Chest wall loading in the ICU: pushes, weights, and positions – Annals of Intensive Care
Clinical course and outcomes of cancer patients admitted in medical ICU with sepsis – Journal of the Intensive Care Society
Clinical outcome of wild-type AmpC-producing Enterobacterales infection in critically ill patients treated with β-lactams: a prospective multicenter study – Annals of Intensive Care
Continuous prolonged prone positioning in COVID-19-related ARDS: a multicenter cohort study from Chile – Annals of Intensive Care
Correlation between the hysteresis of the pressure–volume curve and the recruitment-to-inflation ratio in patients with coronavirus disease 2019 – Annals of Intensive Care
Corticotropin-stimulated steroid profiles to predict shock development and mortality in sepsis: From the HYPRESS study – Critical Care
Critical Care and Postoperative Management of the First Human Long Segment Orthotopic Tracheal Transplantation – Critical Care Explorations
Effect of Enteral Guanfacine on Dexmedetomidine Use in the ICU – Critical Care Explorations
Effect of high-flow nasal cannula therapy on thirst sensation and dry mouth after extubation: A single-centre prospective cohort study – Intensive and Critical Care Nursing
Family member perspectives on intensive care unit in-person visiting restrictions during the COVID-19 pandemic: A qualitative study – Intensive and Critical Care Nursing
Flow generators for helmet CPAP: Which to prefer? A bench study – Intensive and Critical Care Nursing
Hemoglobin Concentration Impacts Viscoelastic Hemostatic Assays in ICU Admitted Patients – Critical Care Medicine
Impact of Prone Position in COVID-19 Patients on Extracorporeal Membrane Oxygenation – Critical Care Medicine
Impact of secondary sepsis on mortality in adult intensive care unit patients – Intensive and Critical Care Nursing
Incidence and Outcomes of Patients Receiving Chronic Kidney Replacement Therapy Admitted to Scottish ICUs Between 2009 and 2019—A National Observational Cohort Study – Critical Care Medicine
Longitudinal phenotypes in patients with acute respiratory distress syndrome: a multi-database study – Critical Care
Multistate Modeling of Clinical Trajectories and Outcomes in the ICU: A Proof-of-Concept Evaluation of Acute Kidney Injury Among Critically Ill Patients With COVID-19 – Critical Care Explorations
Mobilisation of critically ill patients receiving norepinephrine: a retrospective cohort study – Critical Care
One hundred ECMO retrivals before and during the Covid-19 pandemic: an observational study – Intensive and Critical Care Nursing
Outcomes of Patients With Sepsis and Septic Shock Requiring Source Control: A Prospective Observational Single-Center Study – Critical Care Explorations
Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation – NEJM
Right ventricular free wall longitudinal strain is independently associated with mortality in mechanically ventilated patients with COVID-19 – Annals of Intensive Care
Spontaneous pneumomediastinum: a surrogate of P-SILI in critically ill COVID-19 patients – Critical Care
Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients – Critical Care
The characteristics and factors associated with omitted nursing care in the intensive care unit: A cross-sectional study – Intensive and Critical Care Nursing
The Intensive Care Unit diary — A significant complement in the recovery after intensive care. A focus group study – Intensive and Critical Care Nursing
Timing of dialysis in acute kidney injury using routinely collected data and dynamic treatment regimes – Critical Care
Timing of Prone Positioning During Venovenous Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome – Critical Care Medicine
Trajectories of Palliative Care Needs in the ICU and Long-Term Psychological Distress Symptoms – Critical Care Medicine
Use of an innovative cuff pressure control and subglottic secretions drainage system in COVID-19 ARDS patients undergoing pronation – Critical Care
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date: 6th December 2022
Picture by: Ehimetalor Akhere Unuabona on Unsplash
