Critical Care Evidence Updates – November 2023

Randomised Controlled Trials

A Comparison of High and Usual Protein Dosing in Critically Ill Patients With Obesity: A Post Hoc Analysis of an International, Pragmatic, Single-Blinded, Randomized, Clinical Trial  Critical Care Medicine

Alcohol-based decontamination of gloved hands: A randomized controlled trial  Infection Control & Hospital Epidemiology

Antibiotics with or without Rifaximin for acute hepatic Encephalopathy in critically ill patients with cirrhosis: A double-blind, randomized controlled (ARiE) trial  The American Journal of Gastroenterology

Anti-Factor-Xa and Activated Partial Thromboplastin Time Concordance and Outcomes in Adults Undergoing Extracorporeal Membrane Oxygenation: A Secondary Analysis of the Pilot Low-Dose Heparin in Critically Ill Patients Undergoing Extracorporeal Membrane Oxygenation Randomized Trial  Critical Care Explorations

Aspirin and Hemocompatibility Events With a Left Ventricular Assist Device in Advanced Heart Failure The ARIES-HM3 Randomized Clinical Trial  JAMA

Association of Active Renin Content With Mortality in Critically Ill Patients: A Post hoc Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Trial   Critical Care Medicine

Beta-hydroxy-beta-methylbutyrate supplementation and functional outcomes in multitrauma patients: A pilot randomized controlled trial   Journal of Parenteral and Enteral Nutrition

Comparison of SAT and SBT Conduct During the ABC Trial and PILOT Trial   Journal of Intensive Care Medicine

Determinants of fluid use and the association between volume of fluid used and effect of balanced solutions on mortality in critically ill patients: a secondary analysis of the BaSICS trial   Intensive Care Medicine

Early Left Ventricular Unloading or Conventional Approach After Venoarterial Extracorporeal Membrane Oxygenation: The EARLY-UNLOAD Randomized Clinical Trial   Circulation

Effect of a Standardized Family Participation Program in the ICU: A Multicenter Stepped-Wedge Cluster Randomized Controlled Trial   Critical Care Medicine

Effect of Mechanical Ventilation Mode Type on Postoperative Pulmonary Complications After Cardiac Surgery: A Randomized Controlled Trial   Journal of Cardiothoracic and Vascular Anesthesia

Efficacy and safety of baricitinib or ravulizumab in adult patients with severe COVID-19 (TACTIC-R): a randomised, parallel-arm, open-label, phase 4 trial   The Lancet Respiratory Medicine

Efficacy, safety, and pharmacokinetics of MR13A11A, a generic of remifentanil, for pain management of Japanese patients in the intensive care unit: a double-blinded, fentanyl-controlled, randomized, non-inferiority phase 3 study   Journal of Intensive Care

Fluid balance control in critically ill patients: results from as-treated analyses of POINCARE-2 randomized trial   Critical Care

Hemodynamic effects of supplemental oxygen versus air in simulated blood loss in healthy volunteers: a randomized, controlled, double-blind, crossover trial   Intensive Care Experimental

Passive Movements Do not Appear to Prevent or Reduce Joint Stiffness in Medium to Long-Stay ICU Patients: A Randomized, Controlled, Within-Participant Trial    Critical Care Explorations

Prehospital high-dose methylprednisolone in resuscitated out-of-hospital cardiac arrest patients (STEROHCA): a randomized clinical trial   Intensive Care Medicine

Prostacyclin in trauma patients with hemorrhagic shock–A Randomized Clinical Trial   The Journal of Trauma and Acute Care Surgery

Regional Citrate Anticoagulation versus No Anticoagulation for CKRT in Patients with Liver Failure with Increased Bleeding Risk   CJASN

Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia   NEJM

Risk of Bleeding Following Non–Vitamin K Antagonist Oral Anticoagulant Use in Patients With Acute Ischemic Stroke Treated With Alteplase   JAMA Internal Medicine

Safety and efficacy of glibenclamide combined with rtPA in acute cerebral ischemia with occlusion/stenosis of anterior circulation (SE-GRACE): a randomized, double-blind, placebo-controlled trial   eClinicalMedicine

Short oral regimens for pulmonary rifampicin-resistant tuberculosis (TB-PRACTECAL): an open-label, randomised, controlled, phase 2B-3, multi-arm, multicentre, non-inferiority trial   The Lancet Respiratory Medicine

Sodium Bicarbonate and Calcium Chloride for the Treatment of Hyperkalemia-Induced Cardiac Arrest: A Randomized, Blinded, Placebo-Controlled Animal Study   Critical Care Medicine

The effect of higher or lower mean arterial pressure on kidney function after cardiac arrest: a post hoc analysis of the COMACARE and NEUROPROTECT trials   Annals of Intensive Care

The immunomodulating activity of trimodulin (polyvalent IgM, IgA, IgG solution): a post hoc analysis of the phase II CIGMA trial   Critical Care


COVID-19 rapid guideline: managing COVID-19 NG191

Extracorporeal carbon dioxide removal for acute respiratory failure IPG776

Percutaneous thrombectomy for intermediate-risk or high-risk pulmonary embolism IPG778

Other Guidance/Reports

Guidelines for Neuroprognostication in Critically Ill Adults with Intracerebral Hemorrhage  Neurocritical Care

Guidelines for neuroprognostication in adults with traumatic spinal cord injury  Neurocritical Care

Japanese Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients 2023 (J-ReCIP 2023)  Journal of Intensive Care

Nomenclature of Extracorporeal Blood Purification Therapies for Acute Indications: The Nomenclature Standardization Conference   Blood Purification

The 2023 intensive care society cauldron: Five ways to tackle sustainability   Journal of the Intensive Care Society


Confusion Assessment Method for the Intensive Care Unit (CAM‐ICU) for the diagnosis of delirium in adults in critical care settings

Primary Research

A deep learning model for predicting multidrug-resistant organism infection in critically ill patients  Journal of Intensive Care

Antibiotics, Sedatives, and Catecholamines Further Compromise Sepsis-Induced Immune Suppression in Peripheral Blood Mononuclear Cells   Critical Care Medicine

Association of Early Dexmedetomidine Utilization With Clinical and Functional Outcomes Following Moderate-Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study   Critical Care Medicine

Cefoxitin versus carbapenems as definitive treatment for extended-spectrum β-lactamase-producing Klebsiella pneumoniae bacteremia in intensive care unit: a propensity-matched retrospective analysis   Critical Care

Circulating endothelial extracellular vesicle signatures correspond with ICU requirement: an exploratory study in COVID-19 patients   Intensive Care Medicine Experimental

Combination of serum and peritoneal 1.3-beta-d-glucan can rule out intra-abdominal candidiasis in surgical critically ill patients: a multicenter prospective study   Critical Care

Continuous chest compressions are associated with higher peak inspiratory pressures when compared to 30:2 in an experimental cardiac arrest model   Intensive Care Medicine Experimental

Development and Validation of a Predictive Model for Acute Kidney Injury in Sepsis Patients Based on Recursive Partition Analysis  Journal of Intensive Care Medicine

Diagnostic, prognostic and clinical value of left ventricular radial strain to identify paradoxical septal motion in ventilated patients with the acute respiratory distress syndrome: an observational prospective multicenter study   Critical Care

Early acute kidney injury and transition to renal replacement therapy in critically ill patients with SARS-CoV-2 requiring veno-venous extracorporeal membrane oxygenation   Annals of Intensive Care

Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study   Annals of Intensive Care

Effect on capillary refill time of volume expansion and increase of the norepinephrine dose in patients with septic shock   Critical Care

Effects of early versus delayed application of prone position on ventilation–perfusion mismatch in patients with acute respiratory distress syndrome: a prospective observational study   Critical Care

Efficacy of Early Enhanced Occupational Therapy in an Intensive Care Unit (EFFORT–ICU): A Single-Site Feasibility Trial   American Journal of Occupational Therapy

Epidemiology of ischemic stroke and hemorrhagic stroke in venoarterial extracorporeal membrane oxygenation   Critical Care

Exploring anaesthetists’ views on the carbon footprint of anaesthesia and identifying opportunities and challenges for reducing its impact on the environment   Anaesthesia and Intensive Care

Extracorporeal adsorption of protective and toxic bile acids and bilirubin in patients with cholestatic liver dysfunction: a prospective study   Annals of Intensive Care

Evaluation of the sensory environment in a large tertiary ICU   Critical Care

Factors influencing withdrawal of life-supporting treatment in cervical spinal cord injury: a large multicenter observational cohort study   Critical Care

Fluid Intake in Critically Ill Patients: The “Save Useless Fluids For Intensive Resuscitation” Multicenter Prospective Cohort Study   Critical Care Medicine

Functional Dependence Prior to ICU Admission is Associated with Worse Clinical and Functional Outcomes in Individuals with COVID-19: A Prospective Observational Study   Journal of Intensive Care Medicine

Functional recovery in a cohort of ECMO and non-ECMO acute respiratory distress syndrome survivors   Critical Care

Gastric residual volume monitoring practices in UK intensive care units: A web-based survey   Journal of the Intensive Care Society

Impact of Positive End-Expiratory Pressure and FiO2 on Lung Mechanics and Intrapulmonary Shunt in Mechanically Ventilated Patients with ARDS Due to COVID-19 Pneumonia   Journal of Intensive Care Medicine

In-hospital extracorporeal cardiopulmonary resuscitation for patients with out-of-hospital cardiac arrest: an analysis by time-dependent propensity score matching using a nationwide database in Japan   Critical Care

Inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients   Critical Care

Influence of different noninvasive oxygenation support devices on tidal volume   Annals of Intensive Care

Instruments to assess post-intensive care syndrome assessment: a scoping review and modified Delphi method study    Critical Care

Lessons Learned From a Systematic, Hospital-Wide Implementation of the ABCDEF Bundle: A Survey Evaluation    Critical Care Explorations

Metabolic crisis in maple syrup urine disease: an unusual complication of a rare disease: a case report   Anaesthesia and Intensive Care

Natural language processing diagnosed behavioural disturbance phenotypes in the intensive care unit: characteristics, prevalence, trajectory, treatment, and outcomes   Critical Care

Nutritional support and prevention of post-intensive care syndrome: the Italian SIAARTI survey   Journal of Anesthesia, Analgesia and Critical Care

Nonbronchoscopic Bronchoalveolar Lavage Improves Respiratory Culture Accuracy in Critically Ill Patients   Critical Care Explorations

Observational study of the effect of ketamine infusions on sedation depth, inflammation, and clinical outcomes in mechanically ventilated patients with SARS-CoV-2   Anaesthesia and Intensive Care

Patient and Hospital Characteristics Associated With the Interhospital Transfer of Adult Patients With Sepsis   Critical Care Explorations

Phase III clinical trial comparing the efficacy and safety of adamgammadex with sugammadex for reversal of rocuronium-induced neuromuscular block   British Journal of Anaesthesia

Practice Standards for the Use of Multimodality Neuromonitoring: A Delphi Consensus Process   Critical Care Medicine

Prediction of pulmonary aspergillosis in patients with ventilator-associated pneumonia   Annals of Intensive Care

Predicting Hospital Survival in Patients Admitted to ICU with Pulmonary Embolism   Journal of Intensive Care Medicine

Pre-injury sarcopenia and the association with discharge destination in critical care trauma patients   Trauma

Prognostic Significance of Signs of Life in Out-of-Hospital Cardiac Arrest Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation   Critical Care Medicine

Prognostic value of oxygen saturation index trajectory phenotypes on ICU mortality in mechanically ventilated patients: a multi-database retrospective cohort study   Journal of Intensive Care

Prolonged use of neuromuscular blocking agents is associated with increased long-term mortality in mechanically ventilated medical ICU patients: a retrospective cohort study   Journal of Intensive Care

Subphenotypes in patients with acute respiratory distress syndrome treated with high-flow oxygen   Critical Care

Ten Steps Toward Improving In-Hospital Cardiac Arrest Quality of Care and Outcomes   Resuscitation

The Clearance of Midazolam and Metabolites during Continuous Renal Replacement Therapy in Critically Ill Patients with COVID-19   Blood Purification

The optimal dose of mobilisation therapy in the ICU: a prospective cohort study    Journal of Intensive Care

The Roles of Venopulmonary Arterial Extracorporeal Membrane Oxygenation   Critical Care Medicine

Treatment of cerebral ventriculitis with a new self-irrigating catheter system: narrative review and case series    Journal of Anesthesia, Analgesia and Critical Care

Unresolved issues in the diagnosis of catheter related candidemia: A position paper   REVISTA ESPAÑOLA DE QUIMIOTER

Use of airway pressure-based indices to detect high and low inspiratory effort during pressure support ventilation: a diagnostic accuracy study   Annals of Intensive Care

Using rapid response system trigger clusters to characterize patterns of clinical deterioration among hospitalized adult patients   Resuscitation

Utility of Bedside Ultrasound in Percutaneous Tracheostomy   Journal of Intensive Care Medicine

Variation in coagulation factor activity levels cause discrepancies between activated partial thromboplastin time and anti-Xa activity for heparin monitoring: a retrospective observational study   Journal of Intensive Care

Visualizing the dynamic mechanical power and time burden of mechanical ventilation patients: an analysis of the MIMIC-IV database   Journal of Intensive Care


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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