Critical Care Evidence Updates – November 2023
Randomised Controlled Trials
A Comparison of High and Usual Protein Dosing in Critically Ill Patients With Obesity: A Post Hoc Analysis of an International, Pragmatic, Single-Blinded, Randomized, Clinical Trial Critical Care Medicine
Alcohol-based decontamination of gloved hands: A randomized controlled trial Infection Control & Hospital Epidemiology
Antibiotics with or without Rifaximin for acute hepatic Encephalopathy in critically ill patients with cirrhosis: A double-blind, randomized controlled (ARiE) trial The American Journal of Gastroenterology
Aspirin and Hemocompatibility Events With a Left Ventricular Assist Device in Advanced Heart Failure The ARIES-HM3 Randomized Clinical Trial JAMA
Association of Active Renin Content With Mortality in Critically Ill Patients: A Post hoc Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Trial Critical Care Medicine
Beta-hydroxy-beta-methylbutyrate supplementation and functional outcomes in multitrauma patients: A pilot randomized controlled trial Journal of Parenteral and Enteral Nutrition
Comparison of SAT and SBT Conduct During the ABC Trial and PILOT Trial Journal of Intensive Care Medicine
Determinants of fluid use and the association between volume of fluid used and effect of balanced solutions on mortality in critically ill patients: a secondary analysis of the BaSICS trial Intensive Care Medicine
Effect of a Standardized Family Participation Program in the ICU: A Multicenter Stepped-Wedge Cluster Randomized Controlled Trial Critical Care Medicine
Effect of Mechanical Ventilation Mode Type on Postoperative Pulmonary Complications After Cardiac Surgery: A Randomized Controlled Trial Journal of Cardiothoracic and Vascular Anesthesia
Efficacy and safety of baricitinib or ravulizumab in adult patients with severe COVID-19 (TACTIC-R): a randomised, parallel-arm, open-label, phase 4 trial The Lancet Respiratory Medicine
Efficacy, safety, and pharmacokinetics of MR13A11A, a generic of remifentanil, for pain management of Japanese patients in the intensive care unit: a double-blinded, fentanyl-controlled, randomized, non-inferiority phase 3 study Journal of Intensive Care
Fluid balance control in critically ill patients: results from as-treated analyses of POINCARE-2 randomized trial Critical Care
Hemodynamic effects of supplemental oxygen versus air in simulated blood loss in healthy volunteers: a randomized, controlled, double-blind, crossover trial Intensive Care Experimental
Passive Movements Do not Appear to Prevent or Reduce Joint Stiffness in Medium to Long-Stay ICU Patients: A Randomized, Controlled, Within-Participant Trial Critical Care Explorations
Prehospital high-dose methylprednisolone in resuscitated out-of-hospital cardiac arrest patients (STEROHCA): a randomized clinical trial Intensive Care Medicine
Prostacyclin in trauma patients with hemorrhagic shock–A Randomized Clinical Trial The Journal of Trauma and Acute Care Surgery
Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia NEJM
Risk of Bleeding Following Non–Vitamin K Antagonist Oral Anticoagulant Use in Patients With Acute Ischemic Stroke Treated With Alteplase JAMA Internal Medicine
Short oral regimens for pulmonary rifampicin-resistant tuberculosis (TB-PRACTECAL): an open-label, randomised, controlled, phase 2B-3, multi-arm, multicentre, non-inferiority trial The Lancet Respiratory Medicine
Sodium Bicarbonate and Calcium Chloride for the Treatment of Hyperkalemia-Induced Cardiac Arrest: A Randomized, Blinded, Placebo-Controlled Animal Study Critical Care Medicine
The effect of higher or lower mean arterial pressure on kidney function after cardiac arrest: a post hoc analysis of the COMACARE and NEUROPROTECT trials Annals of Intensive Care
NICE
COVID-19 rapid guideline: managing COVID-19 NG191
Extracorporeal carbon dioxide removal for acute respiratory failure IPG776
Percutaneous thrombectomy for intermediate-risk or high-risk pulmonary embolism IPG778
Other Guidance/Reports
Guidelines for Neuroprognostication in Critically Ill Adults with Intracerebral Hemorrhage Neurocritical Care
Guidelines for neuroprognostication in adults with traumatic spinal cord injury Neurocritical Care
Japanese Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients 2023 (J-ReCIP 2023) Journal of Intensive Care
Nomenclature of Extracorporeal Blood Purification Therapies for Acute Indications: The Nomenclature Standardization Conference Blood Purification
The 2023 intensive care society cauldron: Five ways to tackle sustainability Journal of the Intensive Care Society
Cochrane
Primary Research
A deep learning model for predicting multidrug-resistant organism infection in critically ill patients Journal of Intensive Care
Antibiotics, Sedatives, and Catecholamines Further Compromise Sepsis-Induced Immune Suppression in Peripheral Blood Mononuclear Cells Critical Care Medicine
Circulating endothelial extracellular vesicle signatures correspond with ICU requirement: an exploratory study in COVID-19 patients Intensive Care Medicine Experimental
Continuous chest compressions are associated with higher peak inspiratory pressures when compared to 30:2 in an experimental cardiac arrest model Intensive Care Medicine Experimental
Development and Validation of a Predictive Model for Acute Kidney Injury in Sepsis Patients Based on Recursive Partition Analysis Journal of Intensive Care Medicine
Early acute kidney injury and transition to renal replacement therapy in critically ill patients with SARS-CoV-2 requiring veno-venous extracorporeal membrane oxygenation Annals of Intensive Care
Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study Annals of Intensive Care
Effect on capillary refill time of volume expansion and increase of the norepinephrine dose in patients with septic shock Critical Care
Efficacy of Early Enhanced Occupational Therapy in an Intensive Care Unit (EFFORT–ICU): A Single-Site Feasibility Trial American Journal of Occupational Therapy
Epidemiology of ischemic stroke and hemorrhagic stroke in venoarterial extracorporeal membrane oxygenation Critical Care
Exploring anaesthetists’ views on the carbon footprint of anaesthesia and identifying opportunities and challenges for reducing its impact on the environment Anaesthesia and Intensive Care
Extracorporeal adsorption of protective and toxic bile acids and bilirubin in patients with cholestatic liver dysfunction: a prospective study Annals of Intensive Care
Evaluation of the sensory environment in a large tertiary ICU Critical Care
Fluid Intake in Critically Ill Patients: The “Save Useless Fluids For Intensive Resuscitation” Multicenter Prospective Cohort Study Critical Care Medicine
Functional Dependence Prior to ICU Admission is Associated with Worse Clinical and Functional Outcomes in Individuals with COVID-19: A Prospective Observational Study Journal of Intensive Care Medicine
Functional recovery in a cohort of ECMO and non-ECMO acute respiratory distress syndrome survivors Critical Care
Gastric residual volume monitoring practices in UK intensive care units: A web-based survey Journal of the Intensive Care Society
Impact of Positive End-Expiratory Pressure and FiO2 on Lung Mechanics and Intrapulmonary Shunt in Mechanically Ventilated Patients with ARDS Due to COVID-19 Pneumonia Journal of Intensive Care Medicine
Inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients Critical Care
Influence of different noninvasive oxygenation support devices on tidal volume Annals of Intensive Care
Instruments to assess post-intensive care syndrome assessment: a scoping review and modified Delphi method study Critical Care
Lessons Learned From a Systematic, Hospital-Wide Implementation of the ABCDEF Bundle: A Survey Evaluation Critical Care Explorations
Metabolic crisis in maple syrup urine disease: an unusual complication of a rare disease: a case report Anaesthesia and Intensive Care
Nutritional support and prevention of post-intensive care syndrome: the Italian SIAARTI survey Journal of Anesthesia, Analgesia and Critical Care
Nonbronchoscopic Bronchoalveolar Lavage Improves Respiratory Culture Accuracy in Critically Ill Patients Critical Care Explorations
Observational study of the effect of ketamine infusions on sedation depth, inflammation, and clinical outcomes in mechanically ventilated patients with SARS-CoV-2 Anaesthesia and Intensive Care
Patient and Hospital Characteristics Associated With the Interhospital Transfer of Adult Patients With Sepsis Critical Care Explorations
Phase III clinical trial comparing the efficacy and safety of adamgammadex with sugammadex for reversal of rocuronium-induced neuromuscular block British Journal of Anaesthesia
Practice Standards for the Use of Multimodality Neuromonitoring: A Delphi Consensus Process Critical Care Medicine
Prediction of pulmonary aspergillosis in patients with ventilator-associated pneumonia Annals of Intensive Care
Predicting Hospital Survival in Patients Admitted to ICU with Pulmonary Embolism Journal of Intensive Care Medicine
Prognostic Significance of Signs of Life in Out-of-Hospital Cardiac Arrest Patients Undergoing Extracorporeal Cardiopulmonary Resuscitation Critical Care Medicine
Prognostic value of oxygen saturation index trajectory phenotypes on ICU mortality in mechanically ventilated patients: a multi-database retrospective cohort study Journal of Intensive Care
Prolonged use of neuromuscular blocking agents is associated with increased long-term mortality in mechanically ventilated medical ICU patients: a retrospective cohort study Journal of Intensive Care
Subphenotypes in patients with acute respiratory distress syndrome treated with high-flow oxygen Critical Care
Ten Steps Toward Improving In-Hospital Cardiac Arrest Quality of Care and Outcomes Resuscitation
The Clearance of Midazolam and Metabolites during Continuous Renal Replacement Therapy in Critically Ill Patients with COVID-19 Blood Purification
The optimal dose of mobilisation therapy in the ICU: a prospective cohort study Journal of Intensive Care
The Roles of Venopulmonary Arterial Extracorporeal Membrane Oxygenation Critical Care Medicine
Treatment of cerebral ventriculitis with a new self-irrigating catheter system: narrative review and case series Journal of Anesthesia, Analgesia and Critical Care
Unresolved issues in the diagnosis of catheter related candidemia: A position paper REVISTA ESPAÑOLA DE QUIMIOTER
Use of airway pressure-based indices to detect high and low inspiratory effort during pressure support ventilation: a diagnostic accuracy study Annals of Intensive Care
Utility of Bedside Ultrasound in Percutaneous Tracheostomy Journal of Intensive Care Medicine
Variation in coagulation factor activity levels cause discrepancies between activated partial thromboplastin time and anti-Xa activity for heparin monitoring: a retrospective observational study Journal of Intensive Care
Visualizing the dynamic mechanical power and time burden of mechanical ventilation patients: an analysis of the MIMIC-IV database Journal of Intensive Care
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash