Critical Care Evidence Updates – November 2024

Randomised Controlled Trials

Alteplase in COVID-19 severe hypoxemic respiratory failure: the TRISTARDS multicenter randomized trial  Annals of Intensive Care

Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections  NEJM

Balloon guide catheters for endovascular thrombectomy in patients with acute ischaemic stroke due to large-vessel occlusion in China (PROTECT-MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial  The Lancet

Based -evidence, an intervention study to improve sleep quality in awake adult ICU patients: a prospective, single-blind, clustered controlled trial  Critical Care

Burst steroid therapy for acute heart failure: The CORTAHF randomized, open-label, pilot trial  European Journal of Heart Failure

Chlorhexidine-alcohol compared with povidone-iodine-alcohol skin antisepsis protocols in major cardiac surgery: a randomized clinical trial  Intensive Care Medicine

Colchicine in Acute Myocardial Infarction  NEJM

Comparing the hemodynamic effects of ketamine versus fentanyl bolus in patients with septic shock: a randomized controlled trial  Journal of Anesthesia

Early high-dose cryoprecipitate to reduce mortality in adult patients with traumatic haemorrhage: the CRYOSTAT-2 RCT with cost-effectiveness analysis  NIHR

Effect of a driving pressure-limiting strategy for patients with acute respiratory distress syndrome secondary to community-acquired pneumonia: the STAMINA randomised clinical trial  British Journal of Anaesthesia

Effect of a Machine Learning-Derived Early Warning Tool With Treatment Protocol on Hypotension During Cardiac Surgery and ICU Stay: The Hypotension Prediction 2 (HYPE-2) Randomized Clinical Trial  Critical Care Medicine

Efficacy and safety of adrenomedullin for acute ischemic stroke (AMFIS): a phase 2, randomized, double-blinded, placebo-controlled, clinical trial  eClinicalMedicine

Intracuff alkalinized 2% lignocaine versus air for endotracheal tube induced postoperative sore throat and other laryngotracheal morbidities- A Randomized, controlled trial  Trends in Anaesthesia and Critical Care

Intravenous glibenclamide for cerebral oedema after large hemispheric stroke (CHARM): a phase 3, double-blind, placebo-controlled, randomised trial  The Lancet Neurology

Investigating the effect of enhanced cleaning and disinfection of shared medical equipment on health-care-associated infections in Australia (CLEEN): a stepped-wedge, cluster randomised, controlled trial  The Lancet Infectious Diseases

Length of hospital and intensive care unit stay in patients with invasive candidiasis and/or candidemia treated with rezafungin: a pooled analysis of two randomised controlled trials  Critical Care

Olanzapine versus quetiapine in critically ill patients with hyperactive delirium: Protocol for a multicentre, cluster-randomised, double-crossover, pragmatic clinical trial (CALM-ICU)  Critical Care and Resuscitation

Partial Cardiac Denervation to Prevent Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting – The pCAD-POAF Randomized Clinical Trial  JAMA Cardiology

Personalized positive end-expiratory pressure in spontaneously breathing patients with acute respiratory distress syndrome by simultaneous electrical impedance tomography and transpulmonary pressure monitoring: a randomized crossover trial  Intensive Care Medicine

Protamine Dosing for Heparin Reversal after Cardiopulmonary Bypass: A Double-blinded Prospective Randomized Control Trial Comparing Two Strategies  Anesthesiology

Randomized Trial of the Four Supports Intervention for Surrogate Decision Makers in Intensive Care Units  American Journal of Respiratory and Critical Care Medicine

Routine Spironolactone in Acute Myocardial Infarction  NEJM

Quantification of pulmonary edema using automated lung segmentation on computed tomography in mechanically ventilated patients with acute respiratory distress syndrome  Intensive Care Medicine Experimental

Severe intensive care unit–acquired hypernatraemia: Prevalence, risk factors, trajectory, management, and outcome  Critical Care and Resuscitation

The effect of early intravenous amino acid supplementation in critically ill patients without acute kidney injury: Protocol for a multicentre, randomised, parallel-controlled trial (the ESSENTIAL trial)  Critical Care and Resuscitation

Treating eosinophilic exacerbations of asthma and COPD with benralizumab (ABRA): a double-blind, double-dummy, active placebo-controlled randomised trial  The Lancet Respiratory Medicine

Treatment of Acute Circulatory Failure Based on CO2-O2-Derived Indices: the Lactel randomized multicentre study  Chest

Weaning of non COPD patients at high-risk of extubation failure assessed by lung ultrasound: the WIN IN WEAN multicentre randomised controlled trial  Critical Care

NICE

Asthma pathway (BTS, NICE, SIGN) NG244

Asthma: diagnosis, monitoring and chronic asthma management (BTS, NICE, SIGN) NG245

Other Guidance/Reports

Clinical practice guidelines for the care of patients with a chronic subdural haematoma: multidisciplinary recommendations from presentation to recovery  British Journal of Neurosurgery

Early management of adult sepsis and septic shock: Korean clinical practice guidelines  Acute and Critical Care

Imaging in acute percutaneous mechanical circulatory support in adults: a clinical consensus statement of the Association for Acute CardioVascular Care (ACVC) of the ESC, the European Association of Cardiovascular Imaging (EACVI) of the ESC and the European branch of the Extracorporeal Life Support Organization (EuroELSO)  European Heart Journal Cardiovascular Imaging

Initial surgical management of injuries to the lower extremities in patients with multiple and/or severe injuries – A systematic review and clinical practice guideline update  European Journal of Trauma and Emergency Surgery

Management of critically ill patients in austere environments: good clinical practice by the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI)  Journal of Anesthesia, Analgesia and Critical Care

Preoperative assessment of adults undergoing elective noncardiac surgery – Updated guidelines from the European Society of Anaesthesiology and Intensive Care  European Journal of Anaesthesiology

Preventing central line-associated bloodstream infections: A position paper of the International Society for Infectious Diseases, 2024 update  International Journal of Infectious Diseases

Recommendations for fast-track extubation in adult cardiac surgery patients: a consensus statement  Minverva Anestesiologica

Urgent Reversal of Direct Oral Anticoagulants in Critical and Life-Threatening Bleeding: A Multidisciplinary Expert Consensus  Journal of Clinical Medicine

Cochrane

Fenoldopam for preventing and treating acute kidney injury

Prophylactic use of inotropic agents for the prevention of low cardiac output syndrome and mortality in adults undergoing cardiac surgery

Tranexamic acid for preventing postpartum haemorrhage after caesarean section

Primary Research

A comparison of anti-coagulation monitoring tests in ICU patients receiving a continuous infusion of unfractionated heparin  Critical Care and Resuscitation

ABO Blood Group and Risk Associated With Sepsis-Associated Thrombocytopenia: A Single-Center Retrospective Study  Critical Care Medicine

An Analysis of the Association of Whole Blood Transfusion With the Development of Acute Respiratory Distress Syndrome  Critical Care Medicine

Antibiotic prophylaxis reduced broad-spectrum antibiotics and length of stay in ICU patients with alcohol withdrawal induced refractory delirium tremens  Journal of the Intensive Care Society

Assessing the Role of Blood Gas Analysis in COVID-19 Patients for Early Warning and Clinical Guidance  Journal of Intensive Care Medicine

Bacterial Superinfections in Critically Ill Patients With SARS-CoV-2 Infection: A Retrospective Cohort Study  Journal of Intensive Care Medicine

Biochemical analysis of soft tissue infectious fluids and its diagnostic value in necrotizing soft tissue infections: a 5-year cohort study  Critical Care

Cellular oxygen consumption in patients with diabetic ketoacidosis  Intensive Care Medicine Experimental

Changes in central venous-to-arterial PCO₂ difference and central venous oxygen saturation as markers to define fluid responsiveness in critically ill patients: a pot-hoc analysis of a multi-center prospective study  Critical Care

Clinical characteristics and short-term outcomes of patients with critical acute pulmonary embolism requiring extracorporeal membrane oxygenation: from the COMMAND VTE Registry-2  Journal of Intensive Care

Delivery of evidence-based critical care practices across the United Kingdom: A UK-wide multi-site service evaluation in adult units  Journal of the Intensive Care Society

Differential effects of thiamine and ascorbic acid in clusters of septic patients identified by latent variable analysis  Critical Care

D-PRISM: a global survey-based study to assess diagnostic and treatment approaches in pneumonia managed in intensive care  Critical Care

Early physiologic changes after awake prone positioning predict clinical outcomes in patients with acute hypoxemic respiratory failure  Intensive Care Medicine

Early reduction in gut microbiota diversity in critically ill patients is associated with mortality  Annals of Intensive Care

Exploring Rapid Response Team Activation Impact in Patients with Cirrhosis with Acute Decompensation  Journal of Intensive Care Medicine

Evaluation of Effectiveness and Safety of Dexmedetomidine in non-Mechanically Ventilated COVID-19 Critically ill Patients: A Multicentre Cohort Study  Journal of Intensive Care Medicine

Evaluation of severe rhabdomyolysis on day 30 mortality in trauma patients admitted to intensive care: a propensity score analysis of the Traumabase registry  Critical Care

Experiences and outcomes of patients participating in a perioperative shared decision-making pathway  Anaesthesia and Intensive Care

Factors and machine learning models for predicting successful discontinuation of continuous renal replacement therapy in critically ill patients with acute kidney injury: a retrospective cohort study based on MIMIC-IV database  BMC Nephrology

Factors of prolonged-grief-disorder symptom trajectories for ICU bereaved family surrogates  Critical Care

High-dose Intravenous N-Acetylcysteine in Mechanically Ventilated Patients with COVID-19 Pneumonia: A Propensity-Score Matched Cohort Study  Journal of Intensive Care Medicine

High flow nasal cannula and low level continuous positive airway pressure have different physiological effects during de novo acute hypoxemic respiratory failure  Annals of Intensive Care

ICU-acquired hypernatremia: Prevalence, patient characteristics, trajectory, risk factors, and outcomes  Critical Care and Resuscitation

Identification and validation of respiratory subphenotypes in patients with COVID-19 acute respiratory distress syndrome undergoing prone position  Annals of Intensive Care

Impact of coma duration on functional outcomes at discharge and long-term survival after cardiac arrest  Resuscitation

Impact of inhaled nitric oxide therapy in patients with cardiogenic shock treated with veno-arterial extracorporeal membrane oxygenation combined with Impella: a retrospective cohort study  Journal of Intensive Care

Intracranial pressure trends and clinical outcomes after decompressive hemicraniectomy in malignant middle cerebral artery infarction  Annals of Intensive Care

Long-term health outcomes of COVID-19 in ICU- and non-ICU-treated patients up to 2 years after hospitalization: a longitudinal cohort study (CO-FLOW)  Journal of Intensive Care

Long-term outcomes of patients who received extracorporeal cardiopulmonary resuscitation (ECPR) following in-hospital cardiac arrest: Analysis of EXCEL registry data  Critical Care and Resuscitation

Mitochondrial DNA in plasma and long-term physical recovery of critically ill patients: an observational study  Intensive Care Medicine Experimental

Parenteral calcium administration and outcomes in critically ill patients with hypocalcemia: A retrospective cohort study  Journal of Intensive Medicine

Performance of the Healthy Aging Brain Care Monitor Self Report in Monitoring Post-Intensive Care Syndrome Among Acute Respiratory Failure Survivors  Critical Care Medicine

Prone positioning of nonintubated patients with COVID-19 in Australian intensive care units  Critical Care and Resuscitation

Rocking Motion Therapy for Delirious Patients in the ICU: A Multicenter Randomized Clinical Trial  Critical Care Medicine

Similar Weaning Success Rate with High-Intensity and Sham Inspiratory Muscle Training: A Randomized Controlled Trial (IMweanT)  American Journal of Respiratory and Critical Care Medicine

Systematic vitamin K antagonist reversal with prothrombin complex concentrate in patients with mild traumatic brain injury: randomized controlled trial  European Journal of Emergency Medicine

Target-controlled dialysis for antibiotics (TCD-ABx)  Intensive Care Medicine Experimental

The development of a C5.0 machine learning model in a limited data set to predict early mortality in patients with ARDS undergoing an initial session of prone positioning   Intensive Care Medicine Experimental

The epidemiology of pressure injuries in adult intensive care unit patients supported with extracorporeal membrane oxygenation  Critical Care and Resuscitation

The long-term conditional mortality rate in older ICU patients compared to the general population  Critical Care

The Psychometric Properties of the EuroQol 5D Five Level in Survivors of Critical Illness  Critical Care Medicine

The renin–angiotensin–aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II  Critical Care

Timing of adjunctive vasopressin initiation for septic shock patients and hospital mortality: A multicentre observational study  Critical Care and Resuscitation

Vascular Complications After Venoarterial Extracorporeal Membrane Oxygenation Support: A CT Study  Critical Care Medicine

Vitamin D supplementation can improve the 28-day mortality rate in patients with sepsis-associated acute kidney injury  Renal Failure

Metadata

Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash