Critical Care Evidence Updates – October 2024
Randomised Controlled Trials
Aztreonam–avibactam versus meropenem for the treatment of serious infections caused by Gram-negative bacteria (REVISIT): a descriptive, multinational, open-label, phase 3, randomised trial The Lancest Infectious Diseases
Diabetes Mellitus Is Not a Risk Factor for Difficult Intubation Among Critically Ill Adults: A Secondary Analysis of Multicenter Trials Critical Care Medicine
Early, Individualized Recommendations for Hospitalized Patients With Acute Kidney Injury
A Randomized Clinical Trial JAMA
Early sedation using ciprofol for intensive care unit patients requiring mechanical ventilation: a pooled post-hoc analysis of data from phase 2 and phase 3 trials Annals of Intensive Care
EFFECT of daily antiseptic bathing with octenidine on ICU-acquired bacteremia and ICU-acquired multidrug-resistant organisms: a multicenter, cluster-randomized, double-blind, placebo-controlled, cross-over study Intensive Care Medicine
Efficacy of extended infusion of β-lactam antibiotics for the treatment of febrile neutropenia in haematologic patients (BEATLE): a randomised, multicentre, open-label, superiority clinical trial Clinical Microbiology and Infection
Frequency of Screening and Spontaneous Breathing Trial Techniques – A Randomized Clinical Trial JAMA
HELLO: a protocol for a cluster randomized controlled trial to enhance interpersonal relationships and team cohesion among ICU healthcare professionals Intensive Care Medicine Experimental
Heterogeneity in the Effect of Early Goal-Directed Therapy for Septic Shock: A Secondary Analysis of Two Multicenter International Trials Critical Care Medicine
Heterogeneous impact of Sighs on mortality in patients with acute hypoxemic respiratory failure: insights from the PROTECTION study Annals of Intensive Care
Hypothermia versus normothermia in patients with cardiac arrest and shockable rhythm: a secondary analysis of the TTM-2 study Critical Care
Methylene blue therapy in addition to standard treatment for acute-phase septic shock: a pilot randomized controlled trial Frontiers in Medicine
Microaxial Flow Pump Hemodynamic and Metabolic Effects in Infarct-Related Cardiogenic Shock A Substudy of the DanGer Shock Randomized Clinical Trial JAMA Cardiology
Procalcitonin-Guided Management and Duration of Antibiotic Therapy in Critically Ill Cancer Patients With Sepsis (Pro-Can Study): A Randomized Controlled Trial Critical Care Explorations
Risk Factors for Increased Opioid Use During Postoperative Intensive Care Critical Care Explorations
Small volume fluid resuscitation and supplementation with 20% albumin versus buffered crystalloids in adults with septic shock: A protocol for a randomised feasibility trial Journal of the Intensive Care Society
Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial The Lancet Neurology
The Potential Role of Albumin in Reducing Cardiac Surgery-Associated Acute Kidney Injury: A Randomized Controlled Trial Journal of Cardiothoracic and Vascular Anesthesia
Three-month outcomes and cost-effectiveness of interferon gamma-1b in critically ill patients: a secondary analysis of the PREV-HAP trial Journal of Intensive Care
Utilization of NIRS Monitor to Compare the Regional Cerebral Oxygen Saturation Between Dexmedetomidine and Propofol Sedation in Mechanically Ventilated Critically ill Patients with Sepsis- A Prospective Randomized Control Trial Journal of Intensive Care Medicine
NICE
Acute kidney injury: prevention, detection and management NG148
Other Guidance/Reports
2023 SFMU/GICC-SFC/SFGG expert recommendations for the emergency management of older patients with acute heart failure. Part 2: Therapeutics, pathway of care and ethics Archives of Cardiovascular Diseases
2024 EACTS/EACTAIC Guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP Journal of Cardiothoracic and Vascular Anesthesia
2024 EACTS Guidelines on perioperative medication in adult cardiac surgery European Journal of Cardio-Thoracic Surgery
ACTION-ARC Pediatric and Adult Congenital Heart Disease Ventricular Assist Device Adverse Event Definitions-2023 ASAIO Journal
Cardiac Contributions to Brain Health: A Scientific Statement From the American Heart Association Stroke
Cardio-Oncology and Heart Failure: A Scientific Statement from the Heart Failure Society of America Journal of Cardiac Failure
Environmental sustainability in intensive care: the path forward. An ESICM Green Paper Intensive Care Medicine
European Society of Intensive Care Medicine guidelines on end of life and palliative care in the intensive care unit Intensive Care Medicine
Korean Guidelines for the Management and Antibiotic Therapy in Adult Patients with Hospital-Acquired Pneumonia Tuberculosis & Respiratory Diseases
No benefit from the addition of low-dose ketamine infusion to standard evidence-based care of patients with multiple rib fractures The Journal of Trauma and Acute Care Surgery
Resuscitation on the field of play: a best-practice guideline from Resuscitation Council UK British Journal of Sports Medicine
Cochrane
Interventions for BK virus infection in kidney transplant recipients
Primary Research
A multimodal characterization of cardiopulmonary resuscitation-associated lung edema Intensive Care Medicine Experimental
A Retrospective Closed Cohort Study on Distribution of Multidrug-Resistant Bacteria in Ventilator-Associated Pneumonia and its Impact on Patient Outcome Journal of Intensive Care Medicine
A self-regulated expiratory flow device for mechanical ventilation: a bench study Intensive Care Medicine Experimental
Airway epithelium damage in acute respiratory distress syndrome Critical Care
Anaesthesia healthcare workers’ interactions with COVID-19-positive and -suspect patients: A multi-site observational study from Queensland, Australia Anaesthesia and Intensive Care
Associations Between Physical, Cognitive, and Mental Health Domains of Post-Intensive Care Syndrome and Quality of Life: A Longitudinal Multicenter Cohort Study Critical Care Medicine
Awake prone positioning and ventilation distribution as assessed by electric impedance tomography in patients with non-COVID-19 acute respiratory failure: A prospective physiology study Journal of Intensive Medicine
Blood trauma in veno-venous extracorporeal membrane oxygenation: low pump pressures and low circuit resistance matter Critical Care
Causes, Diagnostic Testing, and Treatments Related to Clinical Deterioration Events Among High-Risk Ward Patients Critical Care Explorations
Clinical implementation of advanced respiratory monitoring with esophageal pressure and electrical impedance tomography: results from an international survey and focus group discussion Intensive Care Medicine Experimental
Cognitive and Functional Capacity Assessment of Individuals Who Were Admitted to the Intensive Care Unit Due to COVID-19: A Prospective Cohort Study Journal of Intensive Care Medicine
Comparative Effectiveness of Baricitinib Versus Tocilizumab in Hospitalized Patients With COVID-19: A Retrospective Cohort Study of the National Covid Collaborative Critical Care Medicine
Critical care nurses’ experiences on environmental sustainability: A qualitative content analysis Intensive and Critical Nursing
Development of an Extended Cardiovascular SOFA Score Component Reflecting Cardiac Dysfunction with Improved Survival Prediction in Sepsis: An Exploratory Analysis in the Sepsis and Elevated Troponin (SET) Study Journal of Intensive Care Medicine
Effect of therapeutic plasma exchange on tissue factor and tissue factor pathway inhibitor in septic shock Critical Care
Estimation of transpulmonary driving pressure using a lower assist maneuver (LAM) during synchronized ventilation in patients with acute respiratory failure: a physiological study Intensive Care Medicine Experimental
Extubation Advisor: Implementation and Evaluation of A Novel Extubation Clinical Decision Support Tool Journal of Intensive Care Medicine
Hemorrhages and risk factors in patients undergoing thromboprophylaxis in a respiratory critical care unit: a secondary data analysis of a cohort study Journal of Intensive Care
Identification of novel sub-phenotypes of severe ARDS requiring ECMO using latent class analysis Critical Care
Immunological sub-phenotypes and response to convalescent plasma in COVID-19 induced ARDS: a secondary analysis of the CONFIDENT trial Annals of Intensive Care
Impact of sleep disturbances on outcomes in intensive care units Critical Care
Implementing a Bedside Percutaneous Tracheostomy and Ultrasound Gastrostomy Team Reduces Length of Stay and Hospital Costs Across Multiple Critical Care Units in a 1500 Bed Tertiary Care Center Journal of Intensive Care Medicine
Influence of Right and Left Bundle Branch Block in Patients With Cardiogenic Shock and Cardiac Arrest Critical Care Medicine
Low-Titer O-Positive Whole Blood: Lessons From the Battlefield for Civilian Rural Hospitals Critical Care Nurse
Management of adult mechanically ventilated patients: A UK-wide survey Journal of the Intensive Care Society
Mindfulness Exercises Reduce Acute Physiologic Stress Among Female Clinicians Critical Care Explorations
Outcomes Associated with the use of High Dose Corticosteroids and IL-6 Inhibitors for the Treatment of Acute Respiratory Distress Syndrome Secondary to SARS COV-2 Journal of Intensive Care Medicine
Pathophysiological Markers of Acute Respiratory Distress Syndrome Severity Are Correlated With Ventilation-Perfusion Mismatch Measured by Electrical Impedance Tomography Critical Care Medicine
Persistent Fatigue, Weakness, and Aberrant Muscle Mitochondria in Survivors of Critical COVID-19 Critical Care Explorations
Predicting outcomes in patients with exacerbation of COPD requiring mechanical ventilation Annals of Intensive Care
Routine extracorporeal life support in infarct-related cardiogenic shock: 1-year results of the ECLS-SHOCK trial European Heart Journal
Scandinavian healthcare professionals’ perceptions of rehabilitation practices in the intensive care unit. A cross-sectional survey Intensive and Critical Care Nursing
Severe bleeding events among critically ill patients with haematological malignancies Annals of Intensive Care
Skin injury: Associations with variables related to perfusion and pressure Anaesthesia and Intensive Care
Spontaneous breathing trials should be adapted for each patient according to the critical illness. A new individualised approach: the GLOBAL WEAN study Intensive Care Medicine
Survival After Extracorporeal Cardiopulmonary Resuscitation Based on In-Hospital Cardiac Arrest and Cannulation Location: An Analysis of the Extracorporeal Life Support Organization Registry Critical Care Medicine
Taste in ICU: An unmet need Intensive and Critical Care Nursing
The Benefits of Early Rehabilitation for Patients With Acute Heart Failure Requiring IV Inotropic Drugs Critical Care Medicine
Ultrasound guided transcutaneous phrenic nerve stimulation in critically ill patients: a new method to evaluate diaphragmatic function Anesthesiology
Validating the Fluctuating Mental Status Evaluation in Neurocritically Ill Patients With Acute Stroke Critical Care Medicine
Workload assessment using the nursing activities score in intensive care units: Nationwide prospective observational study in France Intensive and Critical Care Nursing
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash