Critical Care Evidence Updates – October 2024

Randomised Controlled Trials

Anticoagulation Therapy Timing in patients with Atrial Fibrillation after Acute and Chronic Subdural Haematoma (ATTAACH): a pilot randomised controlled trial  BMJ Open

Aztreonam–avibactam versus meropenem for the treatment of serious infections caused by Gram-negative bacteria (REVISIT): a descriptive, multinational, open-label, phase 3, randomised trial  The Lancest Infectious Diseases

Diabetes Mellitus Is Not a Risk Factor for Difficult Intubation Among Critically Ill Adults: A Secondary Analysis of Multicenter Trials  Critical Care Medicine

Early, Individualized Recommendations for Hospitalized Patients With Acute Kidney Injury

A Randomized Clinical Trial  JAMA

Early sedation using ciprofol for intensive care unit patients requiring mechanical ventilation: a pooled post-hoc analysis of data from phase 2 and phase 3 trials  Annals of Intensive Care

EFFECT of daily antiseptic bathing with octenidine on ICU-acquired bacteremia and ICU-acquired multidrug-resistant organisms: a multicenter, cluster-randomized, double-blind, placebo-controlled, cross-over study  Intensive Care Medicine

Effect of Tele-ICU on Clinical Outcomes of Critically Ill Patients – The TELESCOPE Randomized Clinical Trial  JAMA

Efficacy of extended infusion of β-lactam antibiotics for the treatment of febrile neutropenia in haematologic patients (BEATLE): a randomised, multicentre, open-label, superiority clinical trial Clinical Microbiology and Infection

Fluid balance neutralization secured by hemodynamic monitoring versus protocolized standard of care in patients with acute circulatory failure requiring continuous renal replacement therapy: results of the GO NEUTRAL randomized controlled trial  Intensive Care Medicine

Frequency of Screening and Spontaneous Breathing Trial Techniques – A Randomized Clinical Trial  JAMA

HELLO: a protocol for a cluster randomized controlled trial to enhance interpersonal relationships and team cohesion among ICU healthcare professionals  Intensive Care Medicine Experimental

Heterogeneity in the Effect of Early Goal-Directed Therapy for Septic Shock: A Secondary Analysis of Two Multicenter International Trials  Critical Care Medicine

Heterogeneous impact of Sighs on mortality in patients with acute hypoxemic respiratory failure: insights from the PROTECTION study  Annals of Intensive Care

Hypothermia versus normothermia in patients with cardiac arrest and shockable rhythm: a secondary analysis of the TTM-2 study  Critical Care

Methylene blue therapy in addition to standard treatment for acute-phase septic shock: a pilot randomized controlled trial  Frontiers in Medicine

Microaxial Flow Pump Hemodynamic and Metabolic Effects in Infarct-Related Cardiogenic Shock  A Substudy of the DanGer Shock Randomized Clinical Trial  JAMA Cardiology

Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial  The Lancet

Procalcitonin-Guided Management and Duration of Antibiotic Therapy in Critically Ill Cancer Patients With Sepsis (Pro-Can Study): A Randomized Controlled Trial  Critical Care Explorations

Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury – The TRAIN Randomized Clinical Trial  JAMA

Rezafungin versus caspofungin for patients with candidaemia or invasive candidiasis in the intensive care unit: pooled analyses of the ReSTORE and STRIVE randomised trials  Critical Care

Risk Factors for Increased Opioid Use During Postoperative Intensive Care  Critical Care Explorations

Small volume fluid resuscitation and supplementation with 20% albumin versus buffered crystalloids in adults with septic shock: A protocol for a randomised feasibility trial  Journal of the Intensive Care Society

Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial  The Lancet Neurology

The Potential Role of Albumin in Reducing Cardiac Surgery-Associated Acute Kidney Injury: A Randomized Controlled Trial  Journal of Cardiothoracic and Vascular Anesthesia

Three-month outcomes and cost-effectiveness of interferon gamma-1b in critically ill patients: a secondary analysis of the PREV-HAP trial  Journal of Intensive Care

Utilization of NIRS Monitor to Compare the Regional Cerebral Oxygen Saturation Between Dexmedetomidine and Propofol Sedation in Mechanically Ventilated Critically ill Patients with Sepsis- A Prospective Randomized Control Trial  Journal of Intensive Care Medicine

 

NICE

Acute kidney injury: prevention, detection and management NG148

 

Other Guidance/Reports

2023 SFMU/GICC-SFC/SFGG expert recommendations for the emergency management of older patients with acute heart failure. Part 2: Therapeutics, pathway of care and ethics  Archives of Cardiovascular Diseases

2024 EACTS/EACTAIC Guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP  Journal of Cardiothoracic and Vascular Anesthesia

2024 EACTS Guidelines on perioperative medication in adult cardiac surgery  European Journal of Cardio-Thoracic Surgery

ACTION-ARC Pediatric and Adult Congenital Heart Disease Ventricular Assist Device Adverse Event Definitions-2023  ASAIO Journal

Cardiac Arrhythmias and Autonomic Dysfunction Associated With COVID-19: A Scientific Statement From the American Heart Association  Circulation

Cardiac Contributions to Brain Health: A Scientific Statement From the American Heart Association  Stroke

Cardio-Oncology and Heart Failure: A Scientific Statement from the Heart Failure Society of America  Journal of Cardiac Failure

Environmental sustainability in intensive care: the path forward. An ESICM Green Paper  Intensive Care Medicine

European Society of Intensive Care Medicine guidelines on end of life and palliative care in the intensive care unit  Intensive Care Medicine

Korean Guidelines for the Management and Antibiotic Therapy in Adult Patients with Hospital-Acquired Pneumonia  Tuberculosis & Respiratory Diseases

No benefit from the addition of low-dose ketamine infusion to standard evidence-based care of patients with multiple rib fractures  The Journal of Trauma and Acute Care Surgery

Prevention of perioperative venous thromboembolism: 2024 guidelines from the French Working Group on Perioperative Haemostasis (GIHP) developed in collaboration with the French Society of Anaesthesia and Intensive Care Medicine (SFAR), the French Society of Thrombosis and Haemostasis (SFTH) and the French Society of Vascular Medicine (SFMV) and endorsed by the French Society of Digestive Surgery (SFCD), the French Society of Pharmacology and Therapeutics (SFPT) and INNOVTE (Investigation Network On Venous ThromboEmbolism) network  Anaesthesia Critical Care & Pain Medicine

Resuscitation on the field of play: a best-practice guideline from Resuscitation Council UK  British Journal of Sports Medicine

 

Cochrane

Interventions for BK virus infection in kidney transplant recipients

 

Primary Research

A multimodal characterization of cardiopulmonary resuscitation-associated lung edema  Intensive Care Medicine Experimental

A Retrospective Closed Cohort Study on Distribution of Multidrug-Resistant Bacteria in Ventilator-Associated Pneumonia and its Impact on Patient Outcome  Journal of Intensive Care Medicine

A self-regulated expiratory flow device for mechanical ventilation: a bench study  Intensive Care Medicine Experimental

Airway epithelium damage in acute respiratory distress syndrome  Critical Care

Anaesthesia healthcare workers’ interactions with COVID-19-positive and -suspect patients: A multi-site observational study from Queensland, Australia  Anaesthesia and Intensive Care

Associations Between Physical, Cognitive, and Mental Health Domains of Post-Intensive Care Syndrome and Quality of Life: A Longitudinal Multicenter Cohort Study  Critical Care Medicine

Atelectrauma can be avoided if expiration is sufficiently brief: evidence from inverse modeling and oscillometry during airway pressure release ventilation  Critical Care

Awake prone positioning and ventilation distribution as assessed by electric impedance tomography in patients with non-COVID-19 acute respiratory failure: A prospective physiology study  Journal of Intensive Medicine

Blood trauma in veno-venous extracorporeal membrane oxygenation: low pump pressures and low circuit resistance matter  Critical Care

Causes, Diagnostic Testing, and Treatments Related to Clinical Deterioration Events Among High-Risk Ward Patients  Critical Care Explorations

Clinical implementation of advanced respiratory monitoring with esophageal pressure and electrical impedance tomography: results from an international survey and focus group discussion  Intensive Care Medicine Experimental

Cognitive and Functional Capacity Assessment of Individuals Who Were Admitted to the Intensive Care Unit Due to COVID-19: A Prospective Cohort Study  Journal of Intensive Care Medicine

Comparative Effectiveness of Baricitinib Versus Tocilizumab in Hospitalized Patients With COVID-19: A Retrospective Cohort Study of the National Covid Collaborative  Critical Care Medicine

Critical care nurses’ experiences on environmental sustainability: A qualitative content analysis  Intensive and Critical Nursing

Derivation and validation of generalized sepsis-induced acute respiratory failure phenotypes among critically ill patients: a retrospective study  Critical Care

Development of an Extended Cardiovascular SOFA Score Component Reflecting Cardiac Dysfunction with Improved Survival Prediction in Sepsis: An Exploratory Analysis in the Sepsis and Elevated Troponin (SET) Study  Journal of Intensive Care Medicine

Effect of therapeutic plasma exchange on tissue factor and tissue factor pathway inhibitor in septic shock  Critical Care

Estimation of transpulmonary driving pressure using a lower assist maneuver (LAM) during synchronized ventilation in patients with acute respiratory failure: a physiological study  Intensive Care Medicine Experimental

Extracorporeal membrane oxygenation for tuberculosis-related acute respiratory distress syndrome: An international multicentre retrospective cohort study  Critical Care

Extubation Advisor: Implementation and Evaluation of A Novel Extubation Clinical Decision Support Tool  Journal of Intensive Care Medicine

Hemorrhages and risk factors in patients undergoing thromboprophylaxis in a respiratory critical care unit: a secondary data analysis of a cohort study  Journal of Intensive Care

Identification of novel sub-phenotypes of severe ARDS requiring ECMO using latent class analysis  Critical Care

Immunological sub-phenotypes and response to convalescent plasma in COVID-19 induced ARDS: a secondary analysis of the CONFIDENT trial  Annals of Intensive Care

Impact of low dose inhaled nitric oxide treatment in spontaneously breathing and intubated COVID-19 patients: a retrospective propensity-matched study  Critical Care

Impact of sleep disturbances on outcomes in intensive care units  Critical Care

Implementing a Bedside Percutaneous Tracheostomy and Ultrasound Gastrostomy Team Reduces Length of Stay and Hospital Costs Across Multiple Critical Care Units in a 1500 Bed Tertiary Care Center  Journal of Intensive Care Medicine

Incidence, predictability, and outcomes of systemic venous congestion following a fluid challenge in initially fluid-tolerant preload-responders after cardiac surgery: a pilot trial  Critical Care

Influence of Right and Left Bundle Branch Block in Patients With Cardiogenic Shock and Cardiac Arrest  Critical Care Medicine

Interpretable machine learning model for new-onset atrial fibrillation prediction in critically ill patients: a multi-center study  Critical Care

Low-Titer O-Positive Whole Blood: Lessons From the Battlefield for Civilian Rural Hospitals  Critical Care Nurse

Management of adult mechanically ventilated patients: A UK-wide survey  Journal of the Intensive Care Society

Mindfulness Exercises Reduce Acute Physiologic Stress Among Female Clinicians  Critical Care Explorations

Outcomes Associated with the use of High Dose Corticosteroids and IL-6 Inhibitors for the Treatment of Acute Respiratory Distress Syndrome Secondary to SARS COV-2  Journal of Intensive Care Medicine

Pathophysiological Markers of Acute Respiratory Distress Syndrome Severity Are Correlated With Ventilation-Perfusion Mismatch Measured by Electrical Impedance Tomography  Critical Care Medicine

Persistent Fatigue, Weakness, and Aberrant Muscle Mitochondria in Survivors of Critical COVID-19  Critical Care Explorations

Predicting outcomes in patients with exacerbation of COPD requiring mechanical ventilation  Annals of Intensive Care

Regional ventilation dynamics of electrical impedance tomography validated with four-dimensional computed tomography: single-center, prospective, observational study  Critical Care

Routine extracorporeal life support in infarct-related cardiogenic shock: 1-year results of the ECLS-SHOCK trial  European Heart Journal

Scandinavian healthcare professionals’ perceptions of rehabilitation practices in the intensive care unit. A cross-sectional survey  Intensive and Critical Care Nursing

Self-confidence as a mediator in the relationship between executive functioning and depression among ICU survivors: a latent variable analysis  Critical Care

Severe bleeding events among critically ill patients with haematological malignancies  Annals of Intensive Care

Skin injury: Associations with variables related to perfusion and pressure  Anaesthesia and Intensive Care

Spontaneous breathing trials should be adapted for each patient according to the critical illness. A new individualised approach: the GLOBAL WEAN study  Intensive Care Medicine

Stronger association of intact angiotensinogen with mortality than lactate or renin in critical illness: post-hoc analysis from the VICTAS trial  Critical Care

Survival After Extracorporeal Cardiopulmonary Resuscitation Based on In-Hospital Cardiac Arrest and Cannulation Location: An Analysis of the Extracorporeal Life Support Organization Registry  Critical Care Medicine

Taste in ICU: An unmet need  Intensive and Critical Care Nursing

The Benefits of Early Rehabilitation for Patients With Acute Heart Failure Requiring IV Inotropic Drugs  Critical Care Medicine

Ultrasound guided transcutaneous phrenic nerve stimulation in critically ill patients: a new method to evaluate diaphragmatic function  Anesthesiology

Validating the Fluctuating Mental Status Evaluation in Neurocritically Ill Patients With Acute Stroke  Critical Care Medicine

Workload assessment using the nursing activities score in intensive care units: Nationwide prospective observational study in France  Intensive and Critical Care Nursing

 

Metadata

Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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