Critical Care Evidence Updates – September 2021

Systematic Reviews

Balanced crystalloids versus saline in critically ill patients – The PRISMA study of a meta-analysis Medicine

Comparison of two behavioural pain scales for the assessment of procedural pain: A systematic review. Nursing Open

Effect of IV High-Dose Vitamin C on Mortality in Patients With Sepsis – A Systematic Review and Meta-Analysis of Randomized Controlled Trials Critical Care Medicine

Intensive glucose control during the perioperative period for diabetic patients undergoing surgery: An updated systematic review and meta-analysis. Journal of Clinical Anesthesia

The effect of dexmedetomidine on renal function after surgery: A systematic review and meta-analysis. Journal of Clinical Pharmacy and Therapeutics

The impact of wearable continuous vital sign monitoring on deterioration detection and clinical outcomes in hospitalised patients: a systematic review and meta-analysis Critical Care

Timing of tracheostomy in acute traumatic spinal cord injury: a systematic review and meta-analysis. The Journal of Trauma and Acute Care Surgery

Weaning from mechanical ventilation in people with neuromuscular disease: a systematic review. BMJ Open

In case you missed it..


Carnation Ambulatory Monitor for ambulatory detection of cardiac arrythmias MIB275

COVID-19 rapid guideline: managing COVID-19 NG191

End of life care for adults QS13

Midostaurin for treating advanced systemic mastocytosis TA728

Sapropterin for treating hyperphenylalaninaemia in phenylketonuria TA729

Other Guidance/Reports

Ergonomics in the anaesthetic workplace (PDF) Association of Anaesthetists

Intraoperative Management of Adult Patients on Extracorporeal Membrane Oxygenation: an Expert Consensus Statement From the Society of Cardiovascular Anesthesiologists—Part I, Technical Aspects of Extracorporeal Membrane Oxygenation Journal of Cardiothoracic and Vascular Anesthesia

Learning from COVID-19: Reflections of medical leaders  Academy of Medical Royal Colleges

National Essential Anaesthesia Drugs List (NEADL) (PDF) Association of Anaesthetists

UK Career Framework for Pain Nurses (PDF) RCN


Monitoring of gastric residual volume during enteral nutrition

Non‐pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy

SARS‐CoV‐2‐neutralising monoclonal antibodies for treatment of COVID‐19

Primary Research

Admission serum myoglobin and the development of acute kidney injury after major trauma Annals of Intensive Care

Antifungal prophylaxis for prevention of COVID-19-associated pulmonary aspergillosis in critically ill patients: an observational study Critical Care

Association between delay in intensive care unit admission and the host response in patients with community-acquired pneumonia Annals of Intensive Care

Association Between Urine Output and Mortality in Critically Ill Patients – A Machine Learning Approach Critical Care Medicine

Association of deranged cerebrovascular reactivity with brain injury following cardiac arrest: a post-hoc analysis of the COMACARE trial Critical Care

Awake Self–Prone Positioning: Implementation During the COVID-19 Pandemic Critical Care Nurse

Circulating Heart Failure Biomarkers beyond Natriuretic Peptides: updated review from the Biomarker Study Group of the Heart Failure Association (HFA), European Society of Cardiology (ESC). European Journal of Heart Failure

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial Nature Medicine

Critical illness in patients with hematologic malignancy: a population-based cohort study Intensive Care Medicine

Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomised, double-blind, placebo-controlled, phase 3 trial The Lancet Respiratory Medicine

Does inspiration of exhaled CO2 explain improved oxygenation with a face mask plus high-flow nasal cannula oxygen in severe COVID-19 infection? Critical Care. Letter

Early versus late awake prone positioning in non-intubated patients with COVID-19 Critical Care

Effect of a Musical Intervention During the Implantation of a Central Venous Catheter or a Dialysis Catheter in the Intensive Care Unit: A Prospective Randomized Pilot Study Anesthesia & Analgesia

Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients – A Randomized Clinical Trial JAMA

Effectiveness of anisodamine for the treatment of critically ill patients with septic shock: a multicentre randomized controlled trial Critical Care

Effectiveness of polymyxin B hemoperfusion for sepsis depends on the baseline SOFA score: a nationwide observational study Annals of Intensive Care

Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial The Lancet Respiratory medicine

Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications Intensive Care Medicine

Extracorporeal Life Support for Respiratory Failure in Patients With Electronic Cigarette or Vaping Product Use–Associated Lung Injury Critical Care Medicine

Feasibility of machine integrated point of care lung ultrasound automatic B-lines tool in the Corona-virus 2019 critical care unit Critical Care

High-flow nasal oxygen cannula vs. noninvasive mechanical ventilation to prevent reintubation in sepsis: a randomized controlled trial Annals of Intensive Care

High mean arterial pressure target to improve sepsis-associated acute kidney injury in patients with prior hypertension: a feasibility study Annals of Intensive Care

Hydration for prevention of kidney injury after primary coronary intervention for acute myocardial infarction: a randomised clinical trial Heart

Hypothermia for Patients Requiring Evacuation of Subdural Hematoma: A Multicenter Randomized Clinical Trial Neurocritical Care

Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia Journal of Intensive Care

Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study—a randomized clinical trial Intensive Care Medicine

Inhaled amikacin versus placebo to prevent ventilator-associated pneumonia: the AMIKINHAL double-blind multicentre randomised controlled trial protocol BMJ Open

Metoprolol in Critically Ill Patients With COVID-19 Journal of the American College of Cardiology

Nurse Managers Leading the Way: Reenvisioning Stress to Maintain Healthy Work Environments Critical Care Nurse

Perioperative goal-directed therapy in high-risk abdominal surgery. A multicenter randomized controlled superiority trial Journal of Clinical Anesthesia

Phenotypes and subphenotypes of delirium: a review of current categorisations and suggestions for progression Critical Care

Physiological Assessment of Delirium Severity – The Electroencephalographic Confusion Assessment Method Severity Score (E-CAM-S) Critical Care Medicine

Practice of Family-centred Care in Intensive Care Units before the COVID-19-Pandemic: a cross-sectional analysis in German-speaking countries Intensive and Critical Care Nursing

Prevention of hospital-acquired pressure injury in COVID-19 patients in prone position Intensive and Critical Care Nursing

Prolonged Prone Positioning for COVID-19-induced Acute Respiratory Distress Syndrome: : A Randomized Pilot Study Annals of the American Thoracic Society

Promoting Early Mobility in Patients After Transcatheter Aortic Valve Replacement: An Evidence-Based Protocol Critical Care Nurse

Rapid Development and Deployment of an Intensivist-Led Venovenous Extracorporeal Membrane Oxygenation Cannulation Program Critical Care Medicine

Rehabilitation outcomes of survivors of cardiac arrest admitted to ICUs in Australia and New Zealand (ROSC ANZ): A data linkage study Resuscitation

Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial The Lancet Infectious Diseases

Restricted visitation policies in acute care settings during the COVID-19 pandemic: a scoping review Critical Care

Risk factors for invasive aspergillosis in ICU patients with COVID-19: current insights and new key elements Annals of Intensive Care

Role of melatonin in attenuation of hemodynamic response to intubation and anesthetic requirements: a randomized, controlled, double-blind study Brazilian Journal of Anesthesiology

The Effectiveness of High-Flow Nasal Cannula in Coronavirus Disease 2019 Pneumonia – A Retrospective Cohort Study Critical Care Medicine

The use of head helmets to deliver noninvasive ventilatory support: a comprehensive review of technical aspects and clinical findings Critical Care


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date: 4th September 2021
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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