Critical Care Evidence Updates – September 2025
Randomised Controlled Trials
Continuous Vital Sign Monitoring at the Surgical Ward for Improved Outcomes After Major Noncardiac Surgery: A Randomized Clinical Trial Anesthesia & Analgesia
Dexmedetomidine for Analgesia in Nonintubated Patients With Traumatic Rib Fractures A Randomized Clinical Trial JAMA Surgery
Early Discontinuation of Aspirin after PCI in Low-Risk Acute Myocardial Infarction NEJM
Early energy delivery and 28-day mortality in critically ill patients with sepsis: Post hoc analysis of a multicenter cluster-randomised controlled trial Journal of Critical Care
Effect of targeting normoxemia on supplemental oxygen-free days for adults with acute thermal burns: A stepped wedge cluster randomized clinical trial The Journal of Trauma and Acute Care Surgery
Fast Acute Sedation at Intensive Care vs. High-Dose IV Anti-seizure Medication for Treatment of Non-convulsive Status Epilepticus: A Randomized, Multicenter Trial Critical Care Explorations
Heterogeneity in the response to a high vs low mean arterial pressure target in patients with septic shock a post hoc analysis of a randomized controlled trial Intensive Care Medicine
Impact of Conservative Vs. Liberal Extracorporeal Oxygen Target During Venoarterial Extracorporeal Membrane Oxygenation Support for Cardiogenic Shock: A Pilot Randomized Control Trial Critical Care Medicine
Impact of different preferred functional outcomes on the results of the pre-hospital antifibrinolytics for traumatic coagulopathy and hemorrhage (PATCH-trauma) trial Journal of Critical Care
Impact of Conservative Vs. Liberal Extracorporeal Oxygen Target During Venoarterial Extracorporeal Membrane Oxygenation Support for Cardiogenic Shock: A Pilot Randomized Control Trial Critical Care Medicine
Nurse-Led Family Support Intervention for Families of Critically Ill Patients – The FICUS Cluster Randomized Clinical Trial JAMA Internal Medicine
Proactive Telehealth-Based Sepsis Transition and Recovery Support, Hospital Readmission, and Mortality – A Randomized Clinical Trial JAMA Internal Medicine
Prophylactic VA-ECMO During Complex High-Risk PCI: A Randomized Controlled Trial JACC: Advances
Randomized trial of activated vitamin D for acute kidney injury prevention in critically ill patients JCI Insight
Rezafungin Versus Caspofungin for the Treatment of Candidemia and Invasive Candidiasis: Results from the Double-blind, Randomized, Phase 3 ReSTORE Trial Including the China Extension Study Open Forum Infectious Diseases
Other Guidance/Reports
2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Abatacept Clinical Infectious Diseases
Association of Anaesthetists guidelines: safe vascular access 2025 Anaesthesia
Continuous infusion of Beta-Lactams in the critically ill: Considerations for global implementation Journal of Critical Care
Expert consensus statement on the evaluation, treatment, and transfer of cardiogenic shock using a Delphi method approach: a report of the Japan Critical Care Cardiology Committee (J4 CS) Journal of Intensive Care
Preventive Measures and Treatment Options for Atrial Fibrillation Deutsches Arzteblatt
The role of rapid and advanced microbiological methods in critical care: 2025 Emanuele Russo Delphi consensus Clinical Microbiology and Infection
UK consensus statement on priorities to support the process of withdrawal of veno-venous extracorporeal membrane oxygenation British Journal of Anaesthesia
Primary Research
A pilot study to assess the safety and feasibility of a wearable communication device in mechanically ventilated critically ill patients Journal of Critical Care
A reappraisal of association between ventilator-associated events and mortality among critically ill patients using marginal structural model: multicenter observational study Intensive Care Medicine
Association Between Activation of a Rapid Response Team and Outcomes of Sepsis in General Wards: A Nationwide Observational Study Using the Japanese Intensive Care Patient Database Critical Care Medicine
Association Between the Use of Long-Acting Insulin and Hypoglycemia in Critically Ill Patients with Diabetes Journal of Intensive Care Medicine
Association of Ventilatory Ratio with Acute Cor Pulmonale and Mortality in COVID-19 ARDS: A Cohort Study Journal of Intensive Care Medicine
Characteristics and outcomes of nonagenarians admitted to the intensive care unit: A single-centre observational study Anaesthesia and Intensive Care
Comparison of Early Versus Delayed Initiation of Vasopressin in Post-Cardiothoracic Surgery Vasoplegic Shock and the Effect on Post-Operative Atrial Fibrillation Journal of Intensive Care Medicine
Cost-Effectiveness of In-Bed Cycling and Routine Physiotherapy for Patients Receiving Mechanical Ventilation JAMA Network Open
Critical illness and recovery-learning from the shared experience of survivors and their families: A qualitative study Journal of the Intensive Care Society
Decision-Making About Potentially Non-Beneficial Intensive Care Unit Treatments: Interviews of Family Members from an Academic Public Hospital Journal of Intensive Care Medicine
Development and Feasibility Testing of a Sensemaking Coaching Program to Improve Communication Skills for Intensive Care Unit Nurses: A Mixed Methods Study The Journal of Continuing Education in Nursing
Diagnostic and Therapeutic Impact of Critical Care Echocardiography in Patients Admitted in the Intensive Care Unit for Circulatory Or Respiratory Failure Report from an Expert Center Journal of Intensive Care Medicine
Diaphragmatic ultrasound for extubation readiness: The role of thickening fraction Journal of Critical Care
Digital Twins to Evaluate the Risk of Ventilator-Induced Lung Injury During Airway Pressure Release Ventilation Compared With Pressure-Controlled Ventilation Critical Care Medicine
Effect of mannitol on diuresis and acid–base equilibrium in critically ill patients Intensive Care Medicine Experimental
Evaluation of bromocriptine for the reduction of fever in patients with acute neurologic injury: A retrospective cohort study Journal of Critical Care
Evaluation of opioid requirements in mechanically ventilated patients taking buprenorphine/naloxone prior to admission Journal of Critical Care
Evaluation of the Impact of Statin Therapy Intensity on the Risk of Delirium in Critically Ill Patients Admitted to ICUs: A Multicenter Cohort Study Journal of Intensive Care Medicine
Hemodynamic Effects of Guideline-Based Sedation in Mechanically Ventilated Adults: A Multicenter Observational Analysis Critical Care Explorations
Impact of early PaCO2 and pH fluctuations on neurological outcomes in ARDS patients receiving VV ECMO: a retrospective cohort study from the CSECLS registry Annals of Intensive Care
Impact of Metabolically Healthy and Unhealthy Obesity on Outcomes of Sepsis Complicated by Septic Shock in Elderly Patients Journal of Intensive Care Medicine
Long-Term Effects of the Association of Early Neuromuscular Electrical Stimulation With Mobilization in Critically Ill Patients Critical Care Medicine
Is Clinical Outcome Pathogen Related? Characteristics and Outcomes of ICU Patients with Severe Acute Respiratory Infections: Focusing on Respiratory Syncytial Virus, Human Metapneumovirus, Influenza Virus, and Parainfluenza Virus Journal of Intensive Care Medicine
Mental health outcomes at intensive care unit discharge: prevalence, mediators and risk factors Annals of Intensive Care
Midline Catheters as an Alternative for Central Venous Catheters in Venous Pressure Monitoring: A Single Center Experience Journal of Intensive Care Medicine
Multidisciplinary Approach to Early Mobility at an Academic Medical Center Critical Care Medicine
Neurological Outcome Beyond the ICU in Patients with Severe Acute Brain Injury: A Knowledge gap for ICU Teams Journal of Intensive Care Medicine
Non-linear Association Between Lactate Levels and ICU Mortality in Septic Patients: A Multi-Center Study of 13,888 Cases Journal of Intensive Care Medicine
Optimizing Agreement Between Bedside Nurse-Documented and Trained Researcher Delirium Assessments in the ICU Critical Care Medicine
Plasma endostatin and its association with new-onset acute kidney injury in critical care Journal of Intensive Care
Plasma proteomics identifies molecular subtypes in sepsis Critical Care
Recovery of motor functions and cognitive functions in patients with intensive care unit–acquired weakness Journal of Critical Care
Regional venous-to-arterial carbon dioxide pressure and content differences during endotoxemic shock: influence of hydrogen ion accumulation vs. Haldane effect Intensive Care Medicine Experimental
Sepsis and the Heart: In the Quest for Noninvasive Pressure-Volume Loops at the Bedside Critical Care Explorations
Sepsis-induced myocardial dysfunction diagnosed with strain versus non-strain echocardiography parameters: incidence, evolution and association with prognosis Annals of Intensive Care
Severe autoimmune hemolytic anemia in ICU: a place for emergency plasma exchange? A French multicenter retrospective study Critical Care
Severe invasive Streptococcus pyogenes infections: A 15-year observational study with molecular characterization of isolates among intensive care adults Journal of Intensive Medicine
Strategies for discontinuing vasopressin and norepinephrine during the recovery phase of shock: a single-center retrospective study Journal of Intensive Care
Target attainment with continuously administered cefotaxime in critically ill patients – a retrospective cohort study Journal of Critical Care
The association between albumin-corrected anion gap and in-hospital mortality in critically ill COPD patients: A multicenter retrospective study from eICU collaborative research database Journal of Critical Care
The reliability of the plethysmographic perfusion index for detecting fluid responsiveness in critically ill patients Journal of Intensive Medicine
Type 2 Myocardial Infarction and Inpatient Mortality in Septic Shock: Insights from a Nationally Representative Sample Journal of Intensive Care Medicine
Ultrasound-measured brachial artery reactive hyperemia in critically ill patients: an observational study Critical Care
Metadata
Summary author: Rebecca Howes
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash
