Critical Care Evidence Updates – October 2022

Randomised Controlled Trials

A Randomized Pilot Study Assessing if SEDLine Monitoring During Induction of Surgical Patients is Associated With Reduced Dosage of Administered Induction Agents  Seminars in Cardiothoracic and Vascular Anesthesia

A Randomised trial of anti–GM-CSF Otilimab in severe COVID-19 pneumonia (OSCAR)  European Respiratory Journal

Analgesic efficacy of the bilateral erector spinae plane block for colorectal surgery: a randomized controlled trial  Journal of Anesthesia, Analgesia and Critical Care

Avdoralimab (Anti-C5aR1 mAb) Versus Placebo in Patients With Severe COVID-19: Results From a Randomized Controlled Trial (FOR COVID Elimination [FORCE])  Critical Care Medicine

Comparison of ultrasound-guided internal jugular vein and supraclavicular subclavian vein catheterization in critically ill patients: a prospective, randomized clinical trial  Annals of Intensive Care

Decompressive Craniectomy for the Treatment of Severe Diffuse Traumatic Brain Injury: A Randomized Controlled Trial  Asian Journal of Neurosurgery

Early Active Mobilization during Mechanical Ventilation in the ICU  NEJM

Effect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis  A Randomized Clinical Trial  JAMA

Effect of Lower vs Higher Oxygen Saturation Targets on Survival to Hospital Discharge Among Patients Resuscitated After Out-of-Hospital Cardiac Arrest  The EXACT Randomized Clinical Trial  JAMA

Effect of Paroxetine or Quetiapine Combined With Oxycodone vs Oxycodone Alone on Ventilation During Hypercapnia  A Randomized Clinical Trial  JAMA

Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation  A Randomized Clinical Trial  JAMA

Haloperidol for the Treatment of Delirium in ICU Patients  NEJM

Invasive Diagnostic and Therapeutic Management of Cerebral VasoSpasm after Aneurysmal Subarachnoid Hemorrhage (IMCVS)—A Phase 2 Randomized Controlled Trial  Journal of Clinical Medicine

Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus: a multicentre non-inferiority randomised control trial  Journal of Neurology, Neurosurgery & Psychiatry

Low-dose versus high-dose dexamethasone for hospitalized patients with COVID-19 pneumonia: A randomized clinical trial  PLOS One

Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation  NEJM

Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction  NEJM

Randomized Phase 3 Trial of Ruxolitinib for COVID-19–Associated Acute Respiratory Distress Syndrome  Critical Care Medicine

Spontaneous-Breathing Trials with Pressure-Support Ventilation or a T-Piece  NEJM

The cardioprotective and anti-inflammatory effect of inhaled nitric oxide during Fontan surgery in patients with single ventricle congenital heart defects: a prospective randomized study  Journal of Intensive Care

The clinical and paraclinical effectiveness of four-hour infusion vs. half-hour infusion of high-dose ampicillin-sulbactam in treatment of critically ill patients with sepsis or septic shock: An assessor-blinded randomized clinical trial  Journal of Critical Care

Tocilizumab versus baricitinib in hospitalized patients with severe COVID-19: an open label, randomized controlled trial.  Clinical Microbiology and Infection

Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion  NEJM

Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion  NEJM

Volatile Versus Total Intravenous Anesthesia on Postoperative Delirium in Adult Patients Undergoing Cardiac Valve Surgery: A Randomized Clinical Trial  Anaesthesia & Analgesia

Other Guidance/Reports

Acute mesenteric ischemia: updated guidelines of the World Society of Emergency Surgery  World Journal of Emergency Surgery

EFSUMB Clinical Practice Guidelines for Point-of-Care Ultrasound: Part One (Common Heart and Pulmonary Applications) LONG VERSION  European Journal of Ultrasound

Evaluation and management of cancer patients presenting with acute cardiovascular disease: a Clinical Consensus Statement of the Acute CardioVascular Care Association (ACVC) and the ESC council of Cardio-Oncology—part 2: acute heart failure, acute myocardial diseases, acute venous thromboembolic diseases, and acute arrhythmias  European Heart Journal

Expert consensus on the diagnosis and treatment of severe and critical coronavirus disease 2019 (COVID-19)  Journal of Intensive Medicine

Follow-up strategies for patients with splenic trauma managed non-operatively: the 2022 World Society of Emergency Surgery consensus document  World Journal of Emergency Surgery

Integrating electrical impedance tomography and transpulmonary pressure monitoring to personalize PEEP in hypoxemic patients undergoing pressure support ventilation  Critical Care

Lung-protective sedation: moving toward a new paradigm of precision sedation  Intensive Care Medicine

Processed Electroencephalogram-Based Monitoring to Guide Sedation in Critically Ill Adult Patients: Recommendations from an International Expert Panel-Based Consensus  Neurocritical Care

Ten areas for ICU clinicians to be aware of to help retain nurses in the ICU  Critical Care


Non‐invasive positive pressure ventilation for central sleep apnoea in adults

Primary Research

A burden of fluid, sodium, and chloride due to intravenous fluid therapy in patients with respiratory support: a post-hoc analysis of a multicenter cohort study  Annals of Intensive Care

A multidisciplinary safety briefing for acutely ill and deteriorating patients: A quality improvement project  Intensive and Critical Care Nursing

Accuracy of clinicians’ ability to predict the need for renal replacement therapy: a prospective multicenter study  Annals of Intensive Care

Agitation is a Common Barrier to Recovery of ICU Patients  Journal of Intensive Care Medicine

An area under the concentration–time curve threshold as a predictor of efficacy and nephrotoxicity for individualizing polymyxin B dosing in patients with carbapenem-resistant gram-negative bacteria  Critical Care

Assessment of Admission COVID-19 Associated Hyperinflammation Syndrome Score in Critically-Ill COVID-19 Patients  Journal of Intensive Care Medicine

Association Between Daily Average of Mobility Achieved During Physical Therapy Sessions and Hospital-Acquired or Ventilator-Associated Pneumonia among Critically Ill Patients  Journal of Intensive Care Medicine

Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors  Critical Care

Association of early dexamethasone therapy with mortality in critically Ill COVID-19 patients: a French multicenter study  Annals of Intensive Care

Awake prone positioning for patients with COVID-19-induced acute hypoxemic respiratory failure  Journal of Intensive Medicine

Characteristics and outcomes of surgical patients admitted to an overnight intensive recovery unit: A retrospective observational study  Anaesthesia and Intensive Care

Chest dual-energy CT to assess the effects of steroids on lung function in severe COVID-19 patients  Critical Care

Circular RNAs to predict clinical outcome after cardiac arrest  Intensive Care Medicine Experimental

Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study  Critical Care

Comparison of Different Ultrasound Methods to Assess Changes in Muscle Mass in Critically ill Patients  Journal of Intensive Care Medicine

Criteria deemed important by ICU patients when designating a reference person  Journal of Intensive Medicine

Dehydration is associated with production of organic osmolytes and predicts physical long-term symptoms after COVID-19: a multicenter cohort study  Critical Care

Delivery decision in pregnant women rescued by ECMO for severe ARDS: a retrospective multicenter cohort study  Critical Care

Development and validation of a user-friendly risk nomogram for the prediction of catheter-associated urinary tract infection in neuro-intensive care patients  Intensive and Critical Care Nursing

Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: a descriptive analysis of the Eurobact II study  Critical Care

Doppler study of portal vein and renal venous velocity predict the appropriate fluid response to diuretic in ICU: a prospective observational echocardiographic evaluation  Critical Care

Epidemiology of ICU-Onset Bloodstream Infection: Prevalence, Pathogens, and Risk Factors Among 150,948 ICU Patients at 85 U.S. Hospitals  Critical Care Medicine

Etoposide treatment in secondary hemophagocytic syndrome: impact on healthcare-associated infections and survival  Annals of Intensive Care

Evaluation of inhaled nitric oxide (iNO) treatment for moderate-to-severe ARDS in critically ill patients with COVID-19: a multicenter cohort study  Critical Care

Evolution of respiratory system compliance and potential for lung recruitment in COVID-19–induced acute respiratory distress syndrome  Journal of Intensive Medicine

Functional Recovery Groups in Critically Ill COVID-19 Patients and Their Associated Factors: From ICU to Hospital Discharge  Critical Care Medicine

High arterial oxygen levels and supplemental oxygen administration in traumatic brain injury: insights from CENTER-TBI and OzENTER-TBI  Intensive Care Medicine

Impact of Dual Intensive Care Unit and Rapid Response Team Nursing Roles on Service Delivery in the Intensive Care Unit  Critical Care Nurse

Impact of frailty on clinical outcomes in patients with and without COVID-19 pneumonitis admitted to intensive care units in Australia and New Zealand: a retrospective registry data analysis  Critical Care

Improving Communication and Response to Clinical Deterioration to Increase Patient Safety in the Intensive Care Unit  Critical Care Nurse

Improving Initial Sepsis Management Through a Nurse-Driven Rapid Response Team Protocol  Critical Care Nurse

In-hospital Outcomes of Patients with Septic Shock and Underlying Chronic Atrial Fibrillation: A Propensity Matched Analysis from A National Dataset  Journal of Intensive Care Medicine

Individualizing mechanical ventilation: titration of driving pressure to pulmonary elastance through Young’s modulus in an acute respiratory distress syndrome animal model  Critical Care

Low-Flow Duration and Outcomes of Extracorporeal Cardiopulmonary Resuscitation in Adults With In-Hospital Cardiac Arrest: A Nationwide Inpatient Database Study  Critical Care Medicine

Microcirculatory alterations in critically ill COVID-19 patients analyzed using artificial intelligence  Critical Care

Optimized diagnosis-based comorbidity measures for all-cause mortality prediction in a national population-based ICU population  Critical Care

Oropharyngeal and intestinal concentrations of opportunistic pathogens are independently associated with death of SARS-CoV-2 critically ill adults  Critical Care

Outcomes of mild-to-moderate postresuscitation shock after non-shockable cardiac arrest and association with temperature management: a post hoc analysis of HYPERION trial data  Annals of Intensive Care

Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial  Critical Care

Patient and Caregiver-Derived Health Service Improvements for Better Critical Care Recovery  Critical Care Medicine

Patient mobilisation in the intensive care unit and evaluation of a multifaceted intervention including Facebook groups: A quasi-experimental study  Intensive and Critical Care Nursing

Predicting responders to prone positioning in mechanically ventilated patients with COVID-19 using machine learning  Annals of Intensive Care

Preparing for the Worst-Case Scenario in a Pandemic: Intensivists Simulate Prioritization and Triage of Scarce ICU Resources  Critical Care Medicine

Preventing Medical Device–Related Pressure Injuries Due to Noninvasive Ventilation Masks and Nasal Cannulas  Critical Care Nurse

Proenkephalin A 119–159 predicts early and successful liberation from renal replacement therapy in critically ill patients with acute kidney injury: a post hoc analysis of the ELAIN trial  Critical Care

Prone positioning in ARDS patients supported with VV ECMO, what we should explore?  Journal of Intensive Care

Pupillary dilation reflex and behavioural pain scale: Study of diagnostic test  Intensive and Critical Care Nursing

Right ventricular outflow tract Doppler flow analysis and pulmonary arterial coupling by transthoracic echocardiography in sepsis: a retrospective exploratory study  Critical Care

Right ventricular strain measurements in critically ill patients: an observational SICS sub-study  Annals of Intensive Care

Serial Measurements of Protein Biomarkers in Sepsis-Induced Acute Respiratory Distress Syndrome  Critical Care Explorations

Short- versus long-course antibiotic therapy for sepsis: a post hoc analysis of the nationwide cohort study  Journal of Intensive Care

Strategies for a safe interhospital transfer with an intubated patient or where readiness for intubation is needed: A critical incidents study  Intensive and Critical Care Nursing

T cell dysregulation in inflammatory diseases in ICU  Intensive Care Medicine Experimental

The association of intensive care capacity transfers with survival in COVID-19 patients from a Scottish district general hospital: A retrospective cohort study  Journal of the Intensive Care Society

The effect of post-reperfusion levosimendan in an experimental intestinal ischemia–reperfusion model  Journal of Anesthesia, Analgesia and Critical Care

The relationship between secondary traumatic stress and burnout in critical care nurses: The mediating effect of resilience  Intensive and Critical Care Nursing

Trends in mortality in septic patients according to the different organ failure during 15 years  Critical Care

What airway management information do anaesthetic charts prompt for? An audit of charts from 132 hospitals across Australia and New Zealand  Anaesthesia and Intensive Care


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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