Category: Evidence-based Medicine

LOGICAL – Conservative Oxygen after Cardiac Arrest

Emergency Medicine, Evidence-based Medicine, Intensive Care Medicine Leave a comment

Conservative Oxygen for Unresponsive Patients after Cardiac Arrest The LOGICAL Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. NEJM. 2026. doi: 10.1056/NEJMoa2513814 Clinical Question In patients who are unresponsive after cardiac arrest, does limiting oxygen exposure to achieve acceptable oxygenation increase the likelihood of surviving with a favourable functional outcome Background Brain damage and unfavourable […]

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ACTiVE – Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation

Evidence-based Medicine, Intensive Care Medicine Leave a comment

Effect of Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial Sinnige J. JAMA 2025. doi:10.1001/jama.2025.24384 Clinical Question Among critically ill mechanically ventilated adults, does early use of an automated closed-loop ventilation system (INTELLiVENT-ASV) increase ventilator-free days at day 28 (VFD-28) compared with protocolled conventional ventilation (CV)? Background Mechanical ventilation carries […]

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