Category: Summaries

A category to collect all the summaries, so that they can be used in menus and widgets. Please don’t expand this – “Specialties” and “Special Topics” have been created as a custom category sets for the clinical topics.

Delirium Reduction via Scripted Family Voice Recordings in Critically Ill Patients Receiving Mechanical Ventilation

28 January 2026 Mark Giza Intensive Care Medicine, Summaries Leave a comment

Delirium Reduction via Scripted Family Voice Recordings in Critically Ill Patients Receiving Mechanical Ventilation CL Munro. Am J Crit Care. 2025; Nov 1;34(6):429-437. doi: 10.4037/ajcc2025486 Clinical Question In mechanically ventilated adult ICU patients, does a structured voice reorientation intervention recorded by family members, compared to usual care, reduce delirium? Background Delirium affects a significant proportion of patients receiving mechanical ventilation. […]

TAVR vs SAVR for severe aortic stenosis

28 January 2026 David Slessor Intensive Care Medicine, Summaries Leave a comment

Clinical Question In adults with asymptomatic severe aortic stenosis and low surgical risk, should transcatheter aortic-valve replacement (TAVR) or surgical aortic-valve replacement (SAVR) be recommended as the preferred initial strategy? Background Management of severe aortic stenosis has evolved rapidly over the past decade, driven largely by the expansion of transcatheter aortic-valve replacement into lower- risk and younger patient populations. While […]

Immunosep – Precision Immunotherapy to Improve Sepsis Outcomes

21 January 2026 Patrick McNamara Intensive Care Medicine Leave a comment

Precision Immunotherapy to Improve Sepsis Outcomes Giamarellos-Bourboulis. JAMA 2025. doi:10.001/jama.2025.24175 Clinical Question In patients with sepsis, does immunotherapy (using either anakinra or human interferon gamma) that is tailored to the type of immune dysregulation lead to a reduction in organ dysfunction at day 9? Background Sepsis can involve a dysregulated immune response to an infection (SIDP, sepsis induced immune dysfunction) […]

CLIPII – Cryopreserved vs Liquid-Stored Platelets

13 January 2026 Generic Contributor Intensive Care Medicine, Peri-operative Medicine Leave a comment

Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding: The CLIP-II Randomized Noninferiority Clinical Trial Reade. JAMA, 2025. doi: 10.1001/jama.2025.23355 Clinical Question In adult cardiac surgery patients at high risk of bleeding, is the transfusion of cryopreserved platelets, compared with conventional liquid-stored platelets, non-inferior in reducing postoperative bleeding within the first 24 hours after ICU admission? Background Platelet transfusion […]

RSI: Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults

14 December 2025 David Slessor Emergency Medicine, Intensive Care Medicine Leave a comment

Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults Casey. NEJM. 2025. doi: 10.1056/NEJMoa2511420 Clinical Question Among adults with non‑traumatic critical illness undergoing emergency tracheal intubation in the ED or ICU, how does induction with ketamine (1–2 mg/kg IV, dosed by actual body weight) versus etomidate (0.2–0.3 mg/kg IV, dosed by actual body weight) affect 28‑day mortality? Background Peri-intubation […]

ANDROMEDA-SHOCK2 – Personalized Hemodynamic Resuscitation

3 December 2025 Tim Law Evidence-based Medicine, Intensive Care Medicine Leave a comment

Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock ANDROMEDA SHOCK 2 Investigators @ShockAndromeda2. JAMA 2025. doi:10.1001/jama.2025.20402 Clinical Question In adult patients with early septic shock, does a personalised haemodynamic resuscitation protocol targeting capillary refill time (CRT) normalisation improve outcomes compared to usual care? Background In septic shock, the pathophysiological mechanisms contributing to the development of a shocked […]

Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery

28 November 2025 Jake Reeve Peri-operative Medicine Leave a comment

Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery: The IMPROVE-multi Randomized Clinical Trial B Saugel. JAMA 2025; doi: 10.1001/jama.2025.17235 Clinical Question In patients undergoing major intra-abdominal surgery, does an individualised blood pressure target, compared to standard care, improve rates of acute kidney injury, acute myocardial infarction, non-fatal cardiac arrest or death within the first 7 days? Background […]

BICARICU-2: NaHCO3 for Metabolic Acidemia

11 November 2025 George Walker Intensive Care Medicine Leave a comment

Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury Jung et al. JAMA 2025. doi: 10.1001/jama.2025.20231 Clinical Question In patients with severe metabolic acidosis (pH ≤7.20) and moderate to severe AKI does the administration of sodium bicarbonate (NaHCO3) compared to placebo reduce 90-day mortality? Background Multiple cardiac, respiratory, renal and neurological pathophysiological consequences of severe academia have been reported […]

Collaborative VLS – Video vs Direct Laryngoscopy for Endotracheal Intubation in the OT

19 September 2025 Daniel Chung Intensive Care Medicine, Summaries Leave a comment

Video Laryngoscopy vs Direct Laryngoscopy for Endotracheal Intubation in the Operating Room A Cluster Randomized Clinical Trial Ruetzler et al. JAMA 2024;331;(15):1279-1286. doi:10.1001/jama.2024.0762 Clinical Question In patients being intubated for cardiac, thoracic or vascular surgery, does initial video laryngoscopy (VL) with a hyperangulated blade or direct laryngoscopy (DL) effect the number of intubation attempts? Background Endotracheal intubation is integral to the […]

REMAP CAP: Corticosteroids

1 September 2025 Generic Contributor Intensive Care Medicine Leave a comment

Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia: The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial Angus. ICM 2025; doi: https://doi.org/10.1007/s00134-025-07861-w Clinical Question In adult patients with severe community acquired pneumonia (CAP) requiring ICU admission, does a 7-day course of intravenous hydrocortisone reduce 90-day mortality? Background Community-acquired pneumonia (CAP) remains a leading cause of ICU admissions and mortality […]

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