Tag: Ventilation

LOGICAL – Conservative Oxygen after Cardiac Arrest

Conservative Oxygen for Unresponsive Patients after Cardiac Arrest The LOGICAL Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. NEJM. 2026. doi: 10.1056/NEJMoa2513814 Clinical Question In patients who are unresponsive after cardiac arrest, does limiting oxygen exposure to achieve acceptable oxygenation increase the likelihood of surviving with a favourable functional outcome Background Brain damage and unfavourable […]

ACTiVE – Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation

28 March 2026 Tim Law Evidence-based Medicine, Intensive Care Medicine Leave a comment

Effect of Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial Sinnige J. JAMA 2025. doi:10.1001/jama.2025.24384 Clinical Question Among critically ill mechanically ventilated adults, does early use of an automated closed-loop ventilation system (INTELLiVENT-ASV) increase ventilator-free days at day 28 (VFD-28) compared with protocolled conventional ventilation (CV)? Background Mechanical ventilation carries […]

VENT-AVOID – Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During COPD Exacerbations

4 February 2026 Daniel Chung Intensive Care Medicine Leave a comment

Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During Exacerbations of Chronic Obstructive Pulmonary Disease: VENT-AVOID Trial – A Randomized Clinical Trial Duggal et al. 2024; American Journal of Respiratory and Critical Care Medicine March 1, 2024 Pages xv-616 Clinical Question In patients with acute exacerbations of COPD who are either failing noninvasive ventilation (NIV) or failing to wean from […]

UK-ROX Trial

27 June 2025 Celia Bradford Intensive Care Medicine Leave a comment

Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients Martin. JAMA June 12 2025; doi:10.1001/jama.2025.9663 Clinical Question In mechanically ventilated adult patients in the ICU, does a strategy of conservative oxygen therapy, targeting a SpO2 of 90% (Range 88-92%) compared with usual care, reduce mortality at 90 days? Background In the United Kingdom, around 184,000 adults are admitted to […]

NAVIGATE: Early noninvasive ventilation in general wards for acute respiratory failure

28 February 2025 Hrishee Vaidya Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

NAVIGATE: Early noninvasive ventilation in general wards for acute respiratory failure Monti et al. for the NAVIGATE Study Group, BJA Feb 2025. doi:10.1016/j.bja.2024.11.023 Clinical Question In adult patients with mild acute respiratory failure (ARF), does a regime of 2-hour cycles of noninvasive ventilation (NIV), delivered on general wards every 8 hours, reduce the progression to severe acute respiratory failure (defined […]

RENOVATE – High-Flow vs NIV

18 December 2024 Generic Contributor Emergency Medicine, Intensive Care Medicine 3 comments

High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients with Acute Respiratory Failure RENOVATE and BRICNet Authors. JAMA 2024. doi: 10.1001/jama.2024.26244 Clinical Question In adult patients with acute respiratory failure does the use of high-flow nasal oxygen compared to noninvasive ventilation reduce the rate of endotracheal intubation or death at 7 days? Background Both high-flow nasal oxygen (HFNO) and noninvasive ventilation […]

PREOXI Trial – Noninvasive Ventilation for Preoxygenation

20 July 2024 Celia Bradford Emergency Medicine, Intensive Care Medicine One comment

In critically ill patients undergoing tracheal intubation does pre-oxygenation with non-invasive ventilation compared with pre-oxygenation with an oxygen mask reduce the incidence of hypoxemia during intubation?

TAME

19 June 2023 George Walker Evidence-based Medicine, Intensive Care Medicine Leave a comment

In patients resuscitated from out-of-hospital cardiac arrest (OOHCA) does targeted mild hypercapnia compared to targeted normocapnia improve 6-month neurological outcomes?

The REST Trial

13 September 2021 Aidan Burrell Intensive Care Medicine One comment

In mechanically ventilated patients with acute hypoxaemic respiratory failure, does lowering tidal volume using extracorporeal carbon dioxide removal, compared with conventional low tidal volume ventilation, improve day 90 all-cause mortality?

RECOVERY-RS

22 August 2021 Celia Bradford Intensive Care Medicine 5 comments

In hospitalised patients with COVID-19 requiring >40% FiO2 to achieve SaO2>94%, does the use of continuous positive airway pressure (CPAP) or high flow nasal oxygen (HFNO) compared with conventional O2 therapy (COT) reduce the incidence of tracheal intubation or death within 30 days?

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