A compendium of critical appraisals in Intensive Care Medicine research and related specialties
In patients with acute anterior ischaemic stroke, is endovascular thrombectomy alone, compared with endovascular thrombectomy preceded by intravenous alteplase, noninferior with respect to modified Rankin score at 90 days?
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In people who have high-risk or moderate-risk exposure to someone with confirmed COVID-19 infection, does taking hydroxychloroquine following the exposure compared to placebo reduce the incidence of a new illness compatible with COVID-19?
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In hospitalised adult patients with evidence of lower respiratory tract infection due to COVID-19, is remdesivir superior to placebo in shortening the time to recovery?
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In adult patients with COVID-19, does combined interferon beta-1b, lopinavir-ritonavir, and ribavirin, compared with lopinavir-ritonavir alone, reduce the time to a negative swab result?
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Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial Wang Y. Lancet; Epub Ahead of Print. doi: https://doi.org/10.1016/S0140-6736(20)31022-9 Clinical Question In patients with severe COVID-19, does intravenous remdesivir, compared with placebo, improve the time to clinical improvement? Background Despite the ongoing research efforts to find a treatment for patients infected with SARS-CoV-2, there are currently no proven […]
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In patients infected with SARS-CoV-2, what is the efficacy and safety of oral lopinavir–ritonavir?
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In patients with severe sepsis what is the sensitivity of blood cultures taken after the initiation of antimicrobial therapy?
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In critically ill, mechanically ventilated patients, does a strategy of no sedation, as compared with light sedation with daily sedation breaks, impact day 90 mortality?
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In patients older than 65-years with vasodilatory hypotension receiving vasopressors, does a target mean arterial pressure (MAP) of 60-65mmHg compared with usual care impact mortality?
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In ICU patients requiring invasive mechanical ventilation, does the use of proton pump inhibitors (PPIs) vs. histamine-2 receptor blockers (H2RBs) for stress-ulcer prophylaxis, reduce 90-day mortality?
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