MIDAS
In patients aged > 18 years who were unable to be liberated from vasopressors for 24 hours, did the addition of midodrine when compared to a placebo result in the earlier discontinuation of vasopressors?
Continue reading »Year: 2020
ATESS
In patients with septic shock, does the use of intravenous vitamin C and thiamine compared to standard therapy improve recovery from organ failure?
Continue reading »LOCO2
In patients with acute respiratory distress syndrome (ARDS), does conservative vs. liberal oxygen reduce death at 28 days?
Continue reading »Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding
In patients with acute upper GI (UGI) bleeding and a Glasgow-Blatchford score ≥ 12, does endoscopy performed within 6 hours of gastroenterological consultation, compared with endoscopy performed within 6 – 24 hours have a lower 30 day mortality?
Continue reading »Propanalol in severe TBI
Beta-Blocker Therapy in Severe Traumatic Brain Injury: A Prospective Randomised Controlled trial Hosseinali Khalili. World J Surgery 2020; 44:1844-1853. https://doi.org/10.1007/s00268-020-05391-8 Clinical Question In patients with severe traumatic brain injury, does the administration of Beta-Blockade, compared with standard care alone, improve in-hospital mortality? Background The main aim of neurocritical in the management of traumatic brain injury is to mitigate the burden […]
Continue reading »PRIMARY SPONTANEOUS PNEUMOTHORAX (PSP) TRIAL
In patients with primary moderate-large spontaneous pneumothorax does conservative management compared to interventional treatment result in acceptable rates of lung re-expansion at 8 weeks
Acceptable was defined as complete lung re-expansion at 8 weeks in 90% of patients
GRECCO-19
In patients hospitalised with symptomatic coronavirus disease 2019, does the administration of colchicine improve clinical & laboratory outcomes?
Continue reading »STARRT-AKI
Standard versus Accelerated Initiation of Renal Replacement Therapy Wald R, Bagshaw S. NEJM July 16 2020 doi:10.1056/NEJMoa2000741 Clinical Question In critically ill patients with severe acute kidney injury, does accelerated initiation of renal replacement therapy compared to standard initiation improve 90 day survival? Background Acute Kidney Injury (AKI) is common in critically ill patients and some case series suggest up […]
Continue reading »RECOVERY: COVID-19 dexamethasone
In hospitalised patients with SARS-CoV-2 infection does dexamethasone in additional to usual care, compared to usual care alone, reduce 28-day mortality?
Continue reading »HALT-IT
In patients with gastrointestinal (GI) bleeding does high dose tranexamic acid (TXA) when compared to a placebo reduce mortality from GI bleeding?
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