Year: 2025

IPC for prevention of upper limb venous thrombosis with PICCs

Intensive Care Medicine, Summaries Leave a comment

Intermittent pneumatic compression can reduce the incidence of upper extremity venous thrombosis after peripherally inserted central catheter placement in traumatic brain injury patients: A randomised control trial Liang et al. Australian Critical Care 2025; 38(6). doi:10.1016/j.aucc.2025.101308 Clinical Question In patients with traumatic brain injury (TBI) on neurointensive care with peripherally-inserted central catheters (PICC), does the use of upper-limb intermittent pneumatic […]

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Positive communication for decreasing burnout in intensive‑care‑unit staff: a cluster‑randomized trial

Intensive Care Medicine, Summaries Leave a comment

Positive communication for decreasing burnout in intensive‑care‑unit staff: a cluster‑randomized trial Azoulay @ElieAzoulay5. Intensive Care Med, 2025; 51:2031-2041. doi.org/10.1007/s00134-025-08134-2 Clinical Question In ICU healthcare professionals, does a multicomponent positive communication intervention, compared with usual care, reduce the prevalence of occupational burnout? Background Burnout prevalence in healthcare professionals in ICU is high Recent international reports have prioritised targeting burnout Observational studies […]

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Delirium Reduction via Scripted Family Voice Recordings in Critically Ill Patients Receiving Mechanical Ventilation

Intensive Care Medicine, Summaries Leave a comment

Delirium Reduction via Scripted Family Voice Recordings in Critically Ill Patients Receiving Mechanical Ventilation CL Munro. Am J Crit Care. 2025; Nov 1;34(6):429-437. doi: 10.4037/ajcc2025486 Clinical Question In mechanically ventilated adult ICU patients, does a structured voice reorientation intervention recorded by family members, compared to usual care, reduce delirium? Background Delirium affects a significant proportion of patients receiving mechanical ventilation. […]

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Immunosep – Precision Immunotherapy to Improve Sepsis Outcomes

Intensive Care Medicine Leave a comment

Precision Immunotherapy to Improve Sepsis Outcomes Giamarellos-Bourboulis. JAMA 2025. doi:10.001/jama.2025.24175 Clinical Question In patients with sepsis, does immunotherapy (using either anakinra or human interferon gamma) that is tailored to the type of immune dysregulation lead to a reduction in organ dysfunction at day 9? Background Sepsis can involve a dysregulated immune response to an infection (SIDP, sepsis induced immune dysfunction) […]

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CLIPII – Cryopreserved vs Liquid-Stored Platelets

Intensive Care Medicine, Peri-operative Medicine Leave a comment

Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding: The CLIP-II Randomized Noninferiority Clinical Trial Reade. JAMA, 2025. doi: 10.1001/jama.2025.23355 Clinical Question In adult cardiac surgery patients at high risk of bleeding, is the transfusion of cryopreserved platelets, compared with conventional liquid-stored platelets, non-inferior in reducing postoperative bleeding within the first 24 hours after ICU admission? Background Platelet transfusion […]

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RSI: Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults

Emergency Medicine, Intensive Care Medicine Leave a comment

Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults Casey. NEJM. 2025. doi: 10.1056/NEJMoa2511420 Clinical Question Among adults with non‑traumatic critical illness undergoing emergency tracheal intubation in the ED or ICU, how does induction with ketamine (1–2 mg/kg IV, dosed by actual body weight) versus etomidate (0.2–0.3 mg/kg IV, dosed by actual body weight) affect 28‑day mortality? Background Peri-intubation […]

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Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery

Peri-operative Medicine Leave a comment

Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery: The IMPROVE-multi Randomized Clinical Trial  B Saugel. JAMA 2025; doi: 10.1001/jama.2025.17235 Clinical Question In patients undergoing major intra-abdominal surgery, does an individualised blood pressure target, compared to standard care, improve rates of acute kidney injury, acute myocardial infarction, non-fatal cardiac arrest or death within the first 7 days?  Background […]

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