Year: 2025

Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery

Peri-operative Medicine Leave a comment

Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery: The IMPROVE-multi Randomized Clinical Trial  B Saugel. JAMA 2025; doi: 10.1001/jama.2025.17235 Clinical Question In patients undergoing major intra-abdominal surgery, does an individualised blood pressure target, compared to standard care, improve rates of acute kidney injury, acute myocardial infarction, non-fatal cardiac arrest or death within the first 7 days?  Background […]

Continue reading »

BICARICU-2: NaHCO3 for Metabolic Acidemia

Intensive Care Medicine Leave a comment

Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury Jung et al. JAMA 2025. doi: 10.1001/jama.2025.20231 Clinical Question In patients with severe metabolic acidosis (pH ≤7.20) and moderate to severe AKI  does the administration of sodium bicarbonate (NaHCO3) compared to placebo reduce 90-day mortality? Background Multiple cardiac, respiratory, renal and neurological pathophysiological consequences of severe academia have been reported […]

Continue reading »

REMAP CAP: Corticosteroids

Intensive Care Medicine Leave a comment

Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia: The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial Angus. ICM 2025; doi: https://doi.org/10.1007/s00134-025-07861-w Clinical Question In adult patients with severe community acquired pneumonia (CAP) requiring ICU admission, does a 7-day course of intravenous hydrocortisone reduce 90-day mortality? Background Community-acquired pneumonia (CAP) remains a leading cause of ICU admissions and mortality […]

Continue reading »

Target Protein – Augmented Enteral Protein During Critical Illness

Intensive Care Medicine Leave a comment

Augmented Enteral Protein During Critical Illness MJ Summers. JAMA 2025; doi: 10.1001/jama.2025.9110 Clinical Question In critically ill patients receiving enteral nutrition does the augmentation of protein delivery compared to standard care result in an increased number of days free of the index hospital and alive at day 90? Background Critical illness weakness is a common complication within the ICU population […]

Continue reading »

Shared Decision Making in Resuscitation Decisions

Intensive Care Medicine, Peri-operative Medicine Leave a comment

A Randomized Trial of Shared Decision-Making in Code Status Discussions Becker. NEJM Evidence 2025; doi:10.1056/EVIDoa2400422 Clinical Question In hospitalized adults requiring code status discussions, does a shared decision-making approach (including a checklist and decision aid) compared to usual care increase the proportion of patients choosing a DNR status? Background In-hospital cardiac arrest outcomes are poor (<20% survival; ~40% with neurologic […]

Continue reading »
1 2