VIOLET
In critically ill patients with Vitamin D deficiency and a high risk of death, does early enteral replacement of Vitamin D3 compared with placebo improve survival at 90 days?
Continue reading »Year: 2020
ACTT-1
In hospitalised adult patients with evidence of lower respiratory tract infection due to COVID-19, is remdesivir superior to placebo in shortening the time to recovery?
Continue reading »Hung
In adult patients with COVID-19, does combined interferon beta-1b, lopinavir-ritonavir, and ribavirin, compared with lopinavir-ritonavir alone, reduce the time to a negative swab result?
Continue reading »Wang
Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial Wang Y. Lancet; Epub Ahead of Print. doi: https://doi.org/10.1016/S0140-6736(20)31022-9 Clinical Question In patients with severe COVID-19, does intravenous remdesivir, compared with placebo, improve the time to clinical improvement? Background Despite the ongoing research efforts to find a treatment for patients infected with SARS-CoV-2, there are currently no proven […]
Continue reading »LOTUS China
In patients infected with SARS-CoV-2, what is the efficacy and safety of oral lopinavir–ritonavir?
Continue reading »Pandemic Triage
A multicentre evaluation of two intensive care unit triage protocols for use in an influenza pandemic Winston K Cheung. Medical Journal of Australia; August 2012 [3]:178-181. doi:10.5694/mja11.10926] Clinical Question In the event of a viral pandemic, what effect does the use of a triage protocol (specifically the NSW ICU triage protocol) have in increasing ICU bed availability, both in admission […]
Continue reading »FABLED
In patients with severe sepsis what is the sensitivity of blood cultures taken after the initiation of antimicrobial therapy?
Continue reading »CURASMUR
In patients requiring emergency out-of-hospital endotracheal intubation, is rocuronium non-inferior to suxamethonium in providing a successful first pass attempt?
Continue reading »NONSEDA
In critically ill, mechanically ventilated patients, does a strategy of no sedation, as compared with light sedation with daily sedation breaks, impact day 90 mortality?
Continue reading »65 Trial
In patients older than 65-years with vasodilatory hypotension receiving vasopressors, does a target mean arterial pressure (MAP) of 60-65mmHg compared with usual care impact mortality?
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