Critical Care Evidence Updates – April 2022

Randomised Controlled Trials

A randomized-controlled trial comparing 20% albumin to plasmalyte in patients with cirrhosis and sepsis-induced hypotension [ALPS trial] – Journal of Hepatology

A randomised controlled trial of non-invasive ventilation compared with extracorporeal carbon dioxide removal for acute hypercapnic exacerbations of chronic obstructive pulmonary disease – Annals of Intensive Care

Add-on Prostaglandin E1 in Venovenous Extracorporeal Membrane Oxygenation: A Randomized, Double-blind, Placebo-controlled Pilot Trial – American Journal of Respiratory and Critical Care Medicine

Anesthetics to Prevent Lung Injury in Cardiac Surgery: A Randomized Controlled Trial – Journal of Cardiothoracic and Vascular Anaesthesia

Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trial – Critical Care

Closed-loop oxygen control improves oxygen therapy in acute hypoxemic respiratory failure patients under high flow nasal oxygen: a randomized cross-over study (the HILOOP study) – Critical Care

Early versus standard tracheostomy in ventilated patients in neurosurgical intensive care unit: A randomized controlled trial – Journal of Clinical Neuroscience

Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial – JAMA

Effect of Gram Stain–Guided Initial Antibiotic Therapy on Clinical Response in Patients With Ventilator-Associated Pneumonia: The GRACE-VAP Randomized Clinical Trial – JAMA Network Open

Effect of vasopressin and methylprednisolone vs. placebo on long-term outcomes in patients with in-hospital cardiac arrest a randomized clinical trial – Resuscitation

Efficacy of a Communication-Priming Intervention on Documented Goals-of-Care Discussions in Hospitalized Patients With Serious Illness: A Randomized Clinical Trial – JAMA Network Open

High-flow nasal cannula versus conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia: a multicenter randomized controlled trial – Critical Care

Steps to recovery: Body weight-supported treadmill training for critically ill patients: A randomized controlled trial – Journal of Critical Care

The effects of abdominal-based early progressive mobilisation on gastric motility in endotracheally intubated intensive care patients: A randomised controlled trial – Intensive and Critical Care Nursing


COVID-19 rapid guideline: managing COVID-19 NG191

Medicines associated with dependence or withdrawal symptoms: safe prescribing and withdrawal management for adults NG215

Other Guidance/Reports

Assessing the SAfety and FEasibility of bedside portable low-field brain Magnetic Resonance Imaging in patients on ECMO (SAFE-MRI ECMO study): study protocol and first case series experience – Critical Care

Guidelines on enhanced recovery after cardiac surgery under cardiopulmonary bypass or off-pump – Anaesthesia Critical Care & Pain Medicine

Very late intubation in COVID-19 patients: a forgotten prognosis factor? – Critical Care


Videolaryngoscopy versus direct laryngoscopy for adults undergoing tracheal intubation

Primary Research

A novel Vascular Leak Index identifies sepsis patients with a higher risk for in-hospital death and fluid accumulation – Critical Care

A qualitative study of life with a left ventricular assist device as a bridge to transplant: A new normal – Intensive and Critical Care Nursing

Assessment of Awake Prone Positioning in Hospitalized Adults With COVID-19: A Nonrandomized Controlled Trial – JAMA Internal Medicine

Association between early tracheostomy and patient outcomes in critically ill patients on mechanical ventilation: a multicenter cohort study – Journal of Intensive Care

Association between timing of speech and language therapy initiation and outcomes among post-extubation dysphagia patients: a multicenter retrospective cohort study – Critical Care

Defibrotide Therapy for SARS-CoV-2 ARDS – Chest

Derivation and performance of an end-of-life practice score aimed at interpreting worldwide treatment-limiting decisions in the critically ill – Critical Care

Designing devices to communicate effectively with intensive care nurses to prevent pressure injuries: A qualitative study – Intensive and Critical Care Nursing

Determinants of venous return in steady-state physiology and asphyxia-induced circulatory shock and arrest: an experimental study – Intensive Care Medicine Experimental

Development and validation of early prediction models for new-onset functional impairment at hospital discharge of ICU admission – Intensive Care Medicine

Development and Validation of a Multivariable Prediction Model for Postoperative Intensive Care Unit Stay in a Broad Surgical Population – JAMA Surgery

Development of competencies for advanced nursing practice in intensive care units across Europe: A modified e-Delphi study – Intensive and Critical Care Nursing

Diuretics Versus Volume Expansion in the Initial Management of Acute Intermediate High-Risk Pulmonary Embolism – Lung

Dopamine use and its consequences in the intensive care unit: a cohort study utilizing the Japanese Intensive care PAtient Database – Critical Care

Early Neuromuscular Electrical Stimulation in Addition to Early Mobilization Improves Functional Status and Decreases Hospitalization Days of Critically Ill Patients – Critical Care Medicine

Early prolonged prone position in noninvasively ventilated patients with SARS-CoV-2-related moderate-to-severe hypoxemic respiratory failure: clinical outcomes and mechanisms for treatment response in the PRO-NIV study – Critical Care

Echocardiography findings in COVID-19 patients admitted to intensive care units: a multi-national observational study (the ECHO-COVID study) – Intensive Care Medicine

Endovascular Therapy for Acute Stroke with a Large Ischemic Region – NEJM

Evaluation of an extracorporeal ozone-based bactericide system for the treatment of Escherichia coli sepsis – Intensive Care Medicine Experimental

EXpert consensus On Diaphragm UltraSonography in the critically ill (EXODUS): a Delphi consensus statement on the measurement of diaphragm ultrasound-derived parameters in a critical care setting – Critical Care

External chest-wall compression in prolonged COVID-19 ARDS with low-compliance: a physiological study – Annals of Intensive Care

External validation of the 2020 ERC/ESICM prognostication strategy algorithm after cardiac arrest – Critical Care

Extracorporeal membrane oxygenation for severe COVID-19-associated acute respiratory distress syndrome in Poland: a multicenter cohort study – Critical Care

Factors associated with bereaved family surrogates’ satisfaction with end-of-life care in intensive care units – Intensive and Critical Care Nursing

Futile care and burnout in intensive care unit nurses – Intensive and Critical Care Nursing

Gut bacteriobiota and mycobiota are both associated with Day-28 mortality among critically ill patients – Critical Care

Health-related quality of life measured with the EQ-5D-5L in critical care survivors: A cross-sectional study – Intensive and Critical Care Nursing

How nurses’ and physicians’ emotions, psychosocial factors, and professional roles influence the end-of-life decision making process: An interpretive description study – Intensive and Critical Care Nursing

ICU bereaved surrogates’ comorbid psychological-distress states and their associations with prolonged grief disorder – Critical Care

Identifying clinical subtypes in sepsis-survivors with different one-year outcomes: a secondary latent class analysis of the FROG-ICU cohort – Critical Care

Infectious Diseases Society of America 2022 Guidance on the Treatment of Extended-Spectrum β-lactamase Producing Enterobacterales (ESBL-E), Carbapenem-Resistant Enterobacterales (CRE), and Pseudomonas aeruginosa with Difficult-to-Treat Resistance (DTR-P. aeruginosa) – Clinical Infectious Diseases

In-hospital versus out-of-hospital cardiac arrest: Characteristics and outcomes in patients admitted to intensive care after return of spontaneous circulation – Resuscitation

Intensive care-related loss of quality of life and autonomy at 6 months post-discharge: Does COVID-19 really make things worse? – Critical Care

Intensive care unit to unit capacity transfers are associated with increased mortality: an observational cohort study on patient transfers in the Swedish Intensive Care Register – Annals of Intensive Care

Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia – Intensive Care Medicine

Neurologic outcome of VZV encephalitis one year after ICU admission: a multicenter cohort study – Annals of Intensive Care

Optimal timing of introducing mobilization therapy for ICU patients with sepsis – Journal of Intensive Care

Optimization of levetiracetam dosing regimen in critically ill patients with augmented renal clearance: a Monte Carlo simulation study – Journal of Intensive Care

Pain pupillary index to prognosticate unfavorable outcome in comatose cardiac arrest patients – Resuscitation

Patient experiences of an intensive care Liaison Nurse support service – Intensive and Critical Care Nursing

Predictors of response to intra-arterial vasodilatory therapy of non-occlusive mesenteric ischemia in patients with severe shock: results from a prospective observational study – Critical Care

Pulseless electrical activity in in-hospital cardiac arrest – A crossroad for decisions – Resuscitation

Risk factors for peripheral intravascular catheter-related phlebitis in critically ill patients: analysis of 3429 catheters from 23 Japanese intensive care units – Annals of Intensive Care

Serum IL-17 levels are higher in critically ill patients with AKI and associated with worse outcomes – Critical Care

Severe but reversible impaired diaphragm function in septic mechanically ventilated patients – Annals of Intensive Care

Stress-Related Disorders of Family Members of Patients Admitted to the Intensive Care Unit With COVID-19 – JAMA Internal Medicine

Temperature Management in the ICU – Critical Care Medicine

The effect of treatment and clinical course during Emergency Department stay on severity scoring and predicted mortality risk in Intensive Care patients – Critical Care

The Impact of a Machine Learning Early Warning Score on Hospital Mortality: A Multicenter Clinical Intervention Trial – Critical Care Medicine

The necessity of a loading dose when prescribing intravenous colistin in critically ill patients with CRGNB-associated pneumonia: a multi-center observational study – Critical Care

Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study – Critical Care

Ultrasound localization of central vein catheter tip by contrast-enhanced transthoracic ultrasonography: a comparison study with trans-esophageal echocardiography – Critical Care


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date: 12/5/22
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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