Critical Care Evidence Updates – December 2023

Randomised Controlled Trials

A Randomized, Open-Label, Non-inferiority Clinical Trial Assessing 7 Versus 14 Days of Antimicrobial Therapy for Severe Multidrug-Resistant Gram-Negative Bacterial Infections: The OPTIMISE Trial Protocol  Infectious Diseases and Therapy

Adaptive servo-ventilation for sleep-disordered breathing in patients with heart failure with reduced ejection fraction (ADVENT-HF): a multicentre, multinational, parallel-group, open-label, phase 3 randomised controlled trial  The Lancet Respiratory Medicine

Assessment of Individualized Mean Perfusion Pressure Targets for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury—The PrevHemAKI Randomized Controlled Trial  Journal of Clinical Medicine

Association of autoimmune diseases with the occurrence and 28-day mortality of sepsis: an observational and Mendelian randomization study  Critical Care

Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest Trial (GOT ICE): A Randomized Clinical Trial Comparing Outcomes After Aortic Arch Surgery  Circulation

Dual Antiplatelet Treatment up to 72 Hours after Ischemic Stroke  NEJM

Dysnatremia at ICU admission and functional outcome of cardiac arrest: insights from four randomised controlled trials  Critical Care

Effects of a multilevel intervention of resistance training with or without beta-hydroxy-beta-methylbutyrate in medical ICU patients during entire hospitalisation: a four-arm multicentre randomised controlled trial  Critical Care

Effects of enhanced adsorption haemofiltration versus haemoadsorption in severe, refractory septic shock with high levels of endotoxemia: the ENDoX bicentric, randomized, controlled trial  Annals of Intensive Care

Evidence-Based Checklist to Delay Cardiac Arrest in Brain-Dead Potential Organ Donors

The DONORS Cluster Randomized Clinical Trial  JAMA Network Open

High-dose versus low-dose intravenous nitroglycerine for sympathetic crashing acute pulmonary edema: a randomised controlled trial  Emergency Medicine Journal

Individualised, perioperative open-lung ventilation strategy during one-lung ventilation (iPROVE-OLV): a multicentre, randomised, controlled clinical trial  The Lancet Respiratory Medicine

Iron and erythropoietin to heal and recover after intensive care (ITHRIVE): A pilot randomised clinical trial  Critical Care and Resuscitation

Isotonic balanced fluid versus 0.9% saline in patients with moderate to severe traumatic brain injury: A double-blinded randomised controlled trial  The American Journal of Emergency Medicine

Passive Movements Do Not Appear to Prevent or Reduce Joint Stiffness in Medium to Long-Stay ICU Patients: A Randomized, Controlled, Within-Participant Trial  Critical Care Explorations

Pilot Randomized Clinical Trial of a Goals-of-Care Decision Aid for Surrogates of Patients With Severe Acute Brain Injury  Neurology

Prophylactic minocycline for delirium in critically ill patients: a randomized controlled trial  Chest

Remimazolam besylate versus propofol for deep sedation in critically ill patients: a randomized pilot study  Critical Care

Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study  Nature Medicine

Triiodothyronine hormone supplementation therapy in septic shock patients with euthyroid sick syndrome: A two pilot, placebo-controlled, randomized trials  Anaesthesia Critical Care & Pain Medicine


Epilepsies in children, young people and adults QS211

Other Guidance/Reports

Acute care bundles should be used for patients with intracerebral haemorrhage: An expert consensus statement  European Stroke Journal

Cardiac Catheterization Laboratory Management of the Comatose Adult Patient With an Out-of-Hospital Cardiac Arrest: A Scientific Statement From the American Heart Association  Circulation

Clinical application and management of temporary mechanical circulatory support: A clinical consensus  Chinese Medical Journal

Diagnosis and treatment of right ventricular failure secondary to acutely increased right ventricular afterload (acute cor pulmonale). A Clinical Consensus Statement of the Association for Acute CardioVascular Care (ACVC) of the ESC  European Heart Journal – Acute Cardiovascular Care

Expert opinion on bleeding risk from invasive procedures in cirrhosis  JHEP Reports

Facilitating Family Presence During Resuscitation and Invasive Procedures Throughout the Life Span  Critical Care Nurse

Higher versus lower oxygenation targets in adult ICU patients: A rapid practice guideline  Acta Anaesthesiologica Scandinavica

The Infectious Diseases Society of America Guidelines on the Diagnosis of Coronavirus Disease 2019 (COVID-19): Molecular Diagnostic Testing  Clinical Infectious Diseases


Medically assisted hydration for adults receiving palliative care

Primary Research

A pilot study of alternative substrates in the critically Ill subject using a ketogenic feed  Nature Communications

Angiotensin II treatment is associated with improved oxygenation in ARDS patients with refractory vasodilatory shock  Annals of Intensive Care

Association between selective digestive decontamination and decreased rate of acquired candidemia in mechanically ventilated ICU patients: a multicenter nationwide study  Critical Care

Changes in temporal muscle dimensions and their clinical impact in out-of-hospital cardiac arrest survivors  Resuscitation Plus

Characteristics and prognostic factors of bacterial meningitis in the intensive care unit: a prospective nationwide cohort study  Annals of Intensive Care

Comparative before-after study of fever prevention versus targeted temperature management following out-of-hospital cardiac arrest  Resuscitation Plus

Critical illness among patients experiencing homelessness: a retrospective cohort study  Critical Care

Cumulative dose of epinephrine and mode of death after non-shockable out-of-hospital cardiac arrest: a registry-based study  Critical Care

Deep Learning-Based Localization and Detection of Malpositioned Endotracheal Tube on Portable Supine Chest Radiographs in Intensive and Emergency Medicine: A Multicenter Retrospective Study  Critical Care Medicine

Disseminated intravascular coagulation is strongly associated with severe acute kidney injury in patients with septic shock  Annals of Intensive Care

Early and minimal changes in serum creatinine can predict prognosis in elderly patients receiving invasive mechanical ventilation: A retrospective observational study  Journal of Intensive Medicine

Effect of Automated Real-Time Feedback on Early-Sepsis Care: A Pragmatic Clinical Trial  Critical Care Medicine

EPidemiology Of Cardiogenic sHock in Scotland (EPOCHS): A multicentre, prospective observational study of the prevalence, management and outcomes of cardiogenic shock in Scotland  Journal of the Intensive Care Society

Exploring body morphology, sacral skin microclimate and pressure injury development and risk among patients admitted to an intensive care unit: A prospective, observational study  Intensive and Critical Care Nursing

Extracorporeal Membrane Oxygenation Patient Outcomes Following Restrictive Blood Transfusion Protocol  Critical Care Explorations

Factors associated with decreased compliance after on-site extracorporeal membrane oxygenation cannulation for acute respiratory distress syndrome: A retrospective, observational cohort study  Journal of Intensive Medicine

Factors Associated With New Analgesic Requirements Following Critical Illness  Journal of Intensive Care Medicine

Frailty’s influence on 30-day mortality in old critically ill ICU patients: a bayesian analysis evaluating the clinical frailty scale  Annals of Intensive Care

Functional intervention following cardiac surgery to prevent postoperative delirium in older patients (FEEL WELL study)  Journal of Intensive Care

High-Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure Due to COVID-19: A Multicenter Phase II Trial  American Journal of Respiratory and Critical Care Medicine

Higher levels of circulating desphospho-uncarboxylated matrix Gla protein over time are associated with worse survival: the prospective Maastricht Intensive Care COVID cohort  Journal of Intensive Care

ICU Utilization After Implementation of Minor Severe Pneumonia Criteria in Real-Time Electronic Clinical Decision Support  Critical Care Medicine

Impact of blood pressure targets on central hemodynamics during intensive care after out-of-hospital cardiac arrest  Resuscitation

Impact of Preexisting Depression and Anxiety on Hospital Readmission and Long-Term Survival After Cardiac Arrest  Journal of Intensive Care Medicine

Individual response in patient’s effort and driving pressure to variations in assistance during pressure support ventilation  Annals of Intensive Care

Inhaled drug delivery: a randomized study in intubated patients with healthy lungs  Annals of Intensive Care

Intensive care unit mortality and cost-effectiveness associated with intensivist staffing: a Japanese nationwide observational study  Journal of Intensive Care

Interventions to promote cost-effectiveness in adult intensive care units: consensus statement and considerations for best practice from a multidisciplinary and multinational eDelphi study  Critical Care

IntraCranial pressure prediction AlgoRithm using machinE learning (I-CARE): Training and Validation Study  Critical Care Explorations

Meningitis in critically ill patients admitted to intensive care unit for severe community-acquired pneumococcal pneumonia  Annals of Intensive Care

Metabolic disturbances potentially attributable to clogging during continuous renal replacement therapy  Intensive Care Medicine Experimental

Modification in ICU Design May Affect Delirium and Circadian Melatonin: A Proof of Concept Pilot Study  Critical Care Medicine

Modulation of mitochondrial function with near-infrared light reduces brain injury in a translational model of cardiac arrest  Critical Care

Neurological outcome following out of hospital cardiac arrest: Evaluation of performance of existing risk prediction models in a UK cohort  Journal of the Intensive Care Society

Pendelluft in hypoxemic patients resuming spontaneous breathing: proportional modes versus pressure support ventilation  Annals of Intensive Care

Prediction of Th17/Treg cell balance on length of stay in intensive care units of patients with sepsis  Journal of Intensive Medicine

Predicting extubation in patients with traumatic cervical spinal cord injury using the diaphragm electrical activity during a single maximal maneuver  Annals of Intensive Care

Prediction of Long-Term Physical, Mental, and Cognitive Problems Following Critical Illness: Development and External Validation of the PROSPECT Prediction Model  Critical Care Medicine

Prediction of post-traumatic stress disorder in family members of ICU patients: a machine learning approach  Intensive Care Medicine

Prone Positioning in Patients With COVID-19 and Non–COVID-19 Acute Respiratory Distress Syndrome  Critical Care Nurse

Real-Time Camera Image-Guided Nasoenteric Tube Placement in Prone COVID-19 ICU Patients: A Single-Center Study  Journal of Intensive Care Medicine

Relevance of Protein Intake for Weaning in the Mechanically Ventilated Critically Ill: Analysis of a Large International Database  Critical Care Medicine

Severe infections requiring intensive care unit admission in patients receiving ibrutinib for hematological malignancies: a groupe de recherche respiratoire en réanimation onco-hématologique (GRRR-OH) study  Annals of Intensive Care

Sex difference in the risk of extubation failure in ICUs  Annals of Intensive Care

SIN-BARRSS – Developing a mnemonic to support nurses’ participation in interprofessional ward rounds in intensive care: An appreciative inquiry for quality improvement  Intensive and Critical Care Nursing

Strain on Scarce Intensive Care Beds Drives Reduced Patient Volumes, Patient Selection, and Worse Outcome: A National Cohort Study  Critical Care Medicine

The Relationship Between Rest Breaks and Professional Burnout Among Nurses  Critical Care Nurse

Thromboelastography-Guided Correction of Coagulopathy Before Tunneled Central Venous Access in Critically Ill Patients With Liver Disease: A Propensity Score-Matched Study  Critical Care Explorations

Time spent above optimal cerebral perfusion pressure is not associated with failure to improve in outcome in traumatic brain injury  Intensive Care Medicine Experimental

Use of a Digital Air Leak Detection Device to Decrease Chest Tube Duration  Critical Care Nurse

Using a Fluid Resuscitation Algorithm to Reduce the Incidence of Abdominal Compartment Syndrome in the Burn Intensive Care Unit  Critical Care Nurse

Venous Thromboembolism Prophylaxis in Low Body Weight Critically Ill Patients  Journal of Intensive Care Medicine



Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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