Critical Care Evidence Updates – January 2023

Randomised Controlled Trials

A randomized controlled trial comparing non-invasive ventilation delivered using neurally adjusted ventilator assist (NAVA) or adaptive support ventilation (ASV) in patients with acute exacerbation of chronic obstructive pulmonary disease  Journal of Critical Care

Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis after a Fracture  NEJM

Association between driving pressure and postoperative pulmonary complications in patients undergoing lung resection surgery: A randomised clinical trial  Anaesthesia Critical Care & Pain Medicine

Continued enteral nutrition until extubation compared with fasting before extubation in patients in the intensive care unit: an open-label, cluster-randomised, parallel-group, non-inferiority trial  The Lancet Respiratory Medicine

Cytokine hemoadsorption with CytoSorb® in post-cardiac arrest syndrome, a pilot randomized controlled trial  Critical Care

Development and validation of a multivariable model predicting the required catheter dwell time among mechanically ventilated critically ill patients in three randomized trials  Annals of Intensive Care

Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension (RCT)  NEJM

Effect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial  The Lancet Respiratory Medicine

Effectiveness of an intensive care telehealth programme to improve process quality (ERIC): a multicentre stepped wedge cluster randomised controlled trial  Intensive Care Medicine

Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID-19 (Bari-SolidAct): a randomised, double-blind, placebo-controlled phase 3 trial  Critical Care

Effect of High-Dose Selenium on Postoperative Organ Dysfunction and Mortality in Cardiac Surgery Patients – The SUSTAIN CSX Randomized Clinical Trial  JAMA Surgery

Effect of Remifentanil vs Neuromuscular Blockers During Rapid Sequence Intubation on Successful Intubation Without Major Complications Among Patients at Risk of Aspiration – A Randomized Clinical Trial  JAMA

Electric impedance tomography-guided PEEP titration reduces mechanical power in ARDS: a randomized crossover pilot trial  Critical Care

Hypertonic saline infusion does not improve the chance of primary fascial closure after damage control laparotomy: a randomized controlled trial  World Journal of Emergency Surgery

Impact of continuous hypertonic (NaCl 20%) saline solution on renal outcomes after traumatic brain injury (TBI): a post hoc analysis of the COBI trial  Critical Care

Postoperative prophylactic intermittent noninvasive ventilation versus usual postoperative care for patients at high risk of pulmonary complications: a multicentre randomised trial  British Journal of Anaesthesia

Prolonged sedation with sevoflurane in comparison to intravenous sedation in critically ill patients – A randomized controlled trial  Journal of Critical Care

The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial  The Lancet

The Effect of L-Citrulline Supplementation on Outcomes of Critically Ill Patients under Mechanical Ventilation; a Double-Blind Randomized Controlled Trial  Archives of Academic Emergency Medicine

The prevalence of sepsis-induced coagulopathy in patients with sepsis – a secondary analysis of two German multicenter randomized controlled trials   Annals of Intensive Care

Valproic acid as adjuvant treatment for convulsive status epilepticus: a randomised clinical trial  Critical Care


Delirium: prevention, diagnosis and management in hospital and long-term care CG103

Other Guidance/Reports

2022 SPILF – Clinical Practice Guidelines for the Diagnosis and Treatment of Disco-Vertebral Infection in Adults – Infectious Diseases Now

Anaesthetic and peri-operative management for thrombectomy procedures in stroke patients  – Anaesthesia Critical Care & Pain Medicine

Clinical practice guidelines for enhanced recovery after colon and rectal surgery from the American Society of Colon and Rectal Surgeons and the Society of American Gastrointestinal and Endoscopic Surgeons  – Surgical Endoscopy

Implementing human factors in anaesthesia: guidance for clinicians, departments and hospitals – Guidelines from the Difficult Airway Society and the Association of Anaesthetists  – Association of Anaesthetists

Prevention of upper gastrointestinal bleeding in critical illness  – Intensive Care Medicine

Surgical Management and Mechanical Circulatory Support in High-Risk Pulmonary Embolisms: Historical Context, Current Status, and Future Directions: A Scientific Statement From the American Heart Association  – Circulation

Ten recommendations for child-friendly visiting policies in critical care  – Intensive Care Medicine

The Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19: Antigen Testing  – Clinical Infectious Diseases


Hyperimmune immunoglobulin for people with COVID‐19

Medication review in hospitalised patients to reduce morbidity and mortality

Remdesivir for the treatment of COVID‐19

Risk of thromboembolism in patients with COVID‐19 who are using hormonal contraception

Primary Research

A deep learning model for the classification of atrial fibrillation in critically ill patients  Intensive Care Medicine Experimental

Age-adjusted Charlson Comorbidity Index as effective predictor for in-hospital mortality of patients with cardiac arrest: a retrospective study  BMC Emergency Medicine

Association between acute disease severity and one-year quality of life among post-hospitalisation COVID-19 patients: Coalition VII prospective cohort study  Intensive Care Medicine

Association between early nutrition support and 28-day mortality in critically ill patients: the FRANS prospective nutrition cohort study  Critical Care

Association of ultra-early diffusion-weighted magnetic resonance imaging with neurological outcomes after out-of-hospital cardiac arrest  Critical Care

Cardiovascular Subphenotypes in Acute Respiratory Distress Syndrome  Critical Care Medicine

Clinical effectiveness of tigecycline in combination therapy against nosocomial pneumonia caused by CR-GNB in intensive care units: a retrospective multi-centre observational study  Journal of Intensive Care

Clinician perceptions of the impact of ICU family visiting restrictions during the COVID-19 pandemic: an international investigation  Critical Care

Clustering of critically ill patients using an individualized learning approach enables dose optimization of mobilization in the ICU  Critical Care

Early management of isolated severe traumatic brain injury patients in a hospital without neurosurgical capabilities: a consensus and clinical recommendations of the World Society of Emergency Surgery (WSES)  World Journal of Emergency Medicine

Electrical Impedance Tomography As a Bedside Diagnostic Tool for Pulmonary Embolism  Critical Care Explorations

Evaluation of Dexmedetomidine as an Adjunct to Phenobarbital for Alcohol Withdrawal in Critically Ill Patients  Journal of Intensive Care Medicine

Evaluation of Early Tocilizumab Effect on Multiorgan Dysfunction in Critically Ill Patients With COVID-19: A Propensity Score-Matched Study  Journal of Intensive Care Medicine

Identifying Predictors of Extubation on the day of Passing an SBT in Critically ill Adults  Journal of Intensive Care Medicine

Image augmentation and automated measurement of endotracheal-tube-to-carina distance on chest radiographs in intensive care unit using a deep learning model with external validation  Critical Care

Impact of Alcohol Misuse on Requirements for Critical Care Services and Development of Hospital Delirium in Patients With COVID-19 pneumonia  Critical Care Explorations

Impact of Time to Intervention on Catheter-Directed Therapy for Pulmonary Embolism  Critical Care Explorations

Implementation and Impact of Critical Care Pharmacist Addition to a Telecritical Care Network  Critical Care Explorations

Operation clean up: A model for eco-leadership and sustainability implementation  Anaesthesia and Intensive Care

Perioperative changes in fluid distribution and haemodynamics in acute high-risk abdominal surgery  Critical Care

Post-cardiac surgery fungal mediastinitis: clinical features, pathogens and outcome  Critical Care

Relationship Among Clinically Obtained Biomarkers of Inflammation, Hypercoagulability, and Macrophage Activation, and Delirium in Critically Ill Patients With COVID-19  Critical Care Explorations

Role of nebulized colistin as a substitutive strategy against nosocomial pneumonia caused by CR-GNB in intensive care units: a retrospective cohort study  Annals of Intensive Care

Severity scores for status epilepticus in the ICU: systemic illness also matters  Critical Care

Simulation training results in performance retention for the management of airway fires: A prospective observational study  Anaesthesia and Intensive Care

Temporal trends in mortality and provision of intensive care in younger women and men with acute myocardial infarction or stroke  Critical Care

The Early Impact of COVID-19 on Intensive Care Nurses’ Personal and Professional Well-Being: A Qualitative Study  Intensive and Critical Care Nursing

The effect of blood pressure on mortality following out-of-hospital cardiac arrest: a retrospective cohort study of the United Kingdom Intensive Care National Audit and Research Centre database  Critical Care

Urine Output and Mortality in Patients Resuscitated from out of Hospital Cardiac Arrest  Journal of Intensive Care Medicine

Using automatic speckle tracking imaging to measure diaphragm excursion and predict the outcome of mechanical ventilation weaning  Critical Care

Variability in oxygen delivery with bag-valve-mask devices: An observational laboratory simulation study  Anaesthesia and Intensive Care

Variation in Troponin I Measurement and the Cardiovascular Management Approach Following Elevated Troponin I Among Critically Ill Patients With Sepsis  Critical Care Explorations

Ventilation during continuous compressions or at 30:2 compression-to-ventilation ratio results in similar arterial oxygen and carbon dioxide levels in an experimental model of prolonged cardiac arrest  Intensive Care Medicine Experimental


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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