Emergency Evidence Updates – January 2023

Randomised Controlled Trials

Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis after a Fracture  NEJM

Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest (RCT)  NEJM

Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension  NEJM

Implementation of an Electronic Alert to Improve Timeliness of Second Dose Antibiotics for Patients With Suspected Serious Infections in the Emergency Department: A Quasi-Randomized Controlled Trial  Annals of Emergency Medicine

Is Lateral Decubitus or Upright Positioning Optimal for Lumbar Puncture Success in a Teaching Hospital?  The Journal of Emergency Medicine

Valproic acid as adjuvant treatment for convulsive status epilepticus: a randomised clinical trial  Critical Care


Delirium: prevention, diagnosis and management in hospital and long-term care CG103

Hip fracture: management CG124

Other Guidance/Reports

Diagnosis, Workup, Risk Reduction of Transient Ischemic Attack in the Emergency Department Setting: A Scientific Statement From the American Heart Association  Stroke

Prothrombin Complex Concentrate should be Used to Reverse Factor Xa Inhibitors in the Setting of Life-Threatening Bleeding  Annals of Emergency Medicine

The Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19: Antigen Testing  Clinical Infectious Diseases


Remdesivir for the treatment of COVID‐19

Risk of thromboembolism in patients with COVID‐19 who are using hormonal contraception

Primary Research


Association of red blood cells and plasma transfusion versus red blood cell transfusion only with survival for treatment of major traumatic hemorrhage in prehospital setting in England: a multicenter study  Critical Care

Characteristics of patients resuscitated after burn related out-of-hospital cardiac arrest  Resuscitation

Clinical outcomes following out-of-hospital cardiac arrest: The minute-by-minute impact of bystander cardiopulmonary resuscitation  Resuscitation

Effect of video laryngoscopy for non-trauma out-of-hospital cardiac arrest on clinical outcome: A registry-based analysis  Resuscitation

Pre-hospital analgesia in pediatric trauma and critically ill patients: An analysis of a German air rescue service  Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Prehospital vital sign monitoring in paediatric patients: an interregional study of educational interventions  Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Prediction of pre-hospital blood transfusion in trauma patients based on scoring systems  BMC Emergency Medicine

Prehospital Use of Ketamine versus Benzodiazepines for Sedation among Pediatric Patients with Behavioral Emergencies  Prehospital Emergency Care

Prevalence of secondary insults and outcomes of patients with traumatic brain injury intubated in the prehospital setting: a retrospective cohort study  Emergency Medicine Journal



A Qualitative Study of Emergency Physicians’ and Nurses’ Experiences Caring for Patients With Psychiatric Conditions and/or Substance Use Disorders  Annals of Emergency Medicine

Barriers and Best Practices for the Use of Patient-Reported Outcome Measures in Emergency Medicine  Annals of Emergency Medicine

Early prediction of hospital admission of emergency department patients  Emergency Medicine Australasia

EasyTBSA as a method for calculating total body surface area burned: a validation study  Emergency Medicine Journal

Final year medical students as Assistants in Medicine in the emergency department: A pilot study  Emergency Medicine Australasia

First-Attempt Intubation Success Among Emergency Medicine Trainees by Laryngoscopic Device and Training Year: A National Emergency Airway Registry Study  Annals of Emergency Medicine

Implementation of Vertical Split Flow Model for Patient Throughput at a Community Hospital Emergency Department  The Journal of Emergency Medicine

Introduction of an emergency medicine pharmacist-led sepsis alert response system in the emergency department: A cohort study  Emergency Medicine Australasia

Performance of three screening tools to predict COVID-19 positivity in emergency department patients  Emergency Medicine Journal

Psychological and psychosocial aspects of major trauma care: A survey of current practice across UK and Ireland  Trauma



Accidental and Abusive Mandible Fractures in Infants and Toddlers  Pediatric Emergency Care

Analysis of Ear Nose Throat Consultations Requested From the Pediatric Emergency Service in a Tertiary Hospital  Pediatric Emergency Care

Clinical Predictors and Biomarkers in Children With Sepsis and Bacterial Meningitis  Pediatric Emergency Care

Determining the Association Between Emergency Department Crowding and Debriefing After Pediatric Trauma Resuscitations  Pediatric Emergency Care

Early Intravenous Magnesium Sulfate Administration in the Emergency Department for Severe Asthma Exacerbations  Pediatric Emergency Care

Impact on Emergency Department Interventions After Implementing a Guideline Based on the Pediatric Emergency Care Applied Research Network Prediction Rule for Identifying Low-Risk Febrile Infants 29 to 60 Days Old  Pediatric Emergency Care

Intranasal Dexmedetomidine Use in Pediatric Patients for Anxiolysis in the Emergency Department  Pediatric Emergency Care

Is HbA1c an Indicator of Diabetic Ketoacidosis Severity in the Pediatric Population?  Pediatric Emergency Care

Opportunities for Antibiotic Reduction in Pediatric Patients With Urinary Tract Infection After Discharge From the Emergency Department  Pediatric Emergency Care

Outcome of reduction of paediatric forearm fracture by emergency department clinicians  Emergency Medicine Australasia

Pediatric Septic Shock Care Pathways in General Emergency Departments – A Qualitative Study Targeting How to Really Make it Work  Pediatric Emergency Care

The rapid detection of respiratory pathogens in critically ill children  Critical Care

The Use of Ketamine Sedation for the Treatment of Nail Bed Repairs in the Pediatric Emergency Department  Pediatric Emergency Care

Topical Anesthetic for Laceration Repair in Children  Pediatric Emergency Care

Toward Improving Patient Equity in a Pediatric Emergency Department: A Framework for Implementation  Annals of Emergency Medicine

Using Comic-Based Concussion Discharge Instructions to Address Caregiver Health Literacy in the Emergency Department  Journal of Emergency Nursing



Analysis of Clinical and Laboratory Risk Factors of Post-Traumatic Intracranial Hemorrhage in Patients on Direct Oral Anticoagulants with Mild Traumatic Brain Injury: An Observational Multicenter Cohort  The Journal of Emergency Medicine

Diagnostic performance of biomarker S100B and guideline adherence in routine care of mild head trauma  Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Evidence-Based vs Informal Suicide Training: Nurse Confidence and Comfort With Suicidal Patient Care  Journal of Emergency Nursing

Factors associated with longer wait times, admission and reattendances in older patients attending emergency departments: an analysis of linked healthcare data  Emergency Medicine Journal

Impact of time of intensive care unit transfer and outcomes in patients with septic shock: An observational study  Emergency Medicine Australasia

Lung point-of-care ultrasound in the assessment of pleural effusions  Emergency Medicine Journal

Medication Discussions With Patients With Cardiovascular Disease in the Emergency Department: An Opportunity for Emergency Nurses to Engage Patients to Support Medication Reconciliation  Journal of Emergency Nursing

Predictors for Distinguishing Renal Infarction From Urolithiasis in the Emergency Department: A Randomly Matched Retrospective Case-Control Study  The Journal of Emergency Medicine

Under the chest pain center mechanism, whether the nursing handover affects the nursing efficiency and the outcomes of patients with STEMI in the emergency department? A retrospective study  BMC Emergency Medicine

Venous thromboembolism risk following temporary immobilisation after injury: evaluation of the Aberdeen VTE risk tool  Journal of Emergency Nursing


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date: 7th Feb 2023
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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