Critical Care Evidence Updates – July 2022

Randomised Controlled Trials

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Preoperative Antithrombin Supplementation in Patients at Risk for Antithrombin Deficiency After Cardiac Surgery  Anesthesia & Analgesia

Chlorhexidine (di)gluconate locking device for central line infection prevention in intensive care unit patients: a multi-unit, pilot randomized controlled trial  British Journal of Nursing

Effect of 4% Albumin Solution vs Ringer Acetate on Major Adverse Events in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass – A Randomized Clinical Trial  JAMA

Fast versus slow infusion of 20% albumin: a randomized controlled cross-over trial in volunteers  Intensive Care Medicine Experimental

Timing of Exposure to ICU Diaries and Its Impact on Mental Health, Memories, and Quality of Life: A Double-Blind Randomized Control Trial  Critical Care Explorations



COVID-19 rapid guideline: haematopoietic stem cell transplantation NG164

COVID-19 rapid guideline: managing COVID-19 NG191

COVID-19 rapid guideline: vitamin D NG187

Imlifidase for desensitisation treatment before kidney transplant in people with chronic kidney disease TA809

Pneumonia in adults: diagnosis and management CG191

RespiraSense for continuously monitoring respiratory rate MID299


Other Guidance/Reports

ARDS Clinical Practice Guideline 2021  Journal of Intensive Care

Improving the intensive care experience from the perspectives of different stakeholders  Critical Care

Malignant Catatonia: A Review for the Intensivist  Journal of Intensive Care Medicine

The obesity paradox for survivors of critically ill patients  Critical Care

To Wean or Not to Wean: A Practical Patient Focused Guide to Ventilator Weaning  Journal of Intensive Care Medicine



Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults


Interventions for interpersonal communication about end of life care between health practitioners and affected people


Primary Research

90-day Case-Fatality in Critically ill Patients with Chronic Liver Disease Influenced by Presence of Portal Hypertension, Results from a Multicentre Retrospective Cohort Study Journal of Intensive Care Medicine

A Controlled Study in CPR—Survival in Propensity Score Matched Full-Code and Do-Not-Resuscitate ICU Patients  Journal of Intensive Care Medicine

A fatal presentation of DRESS syndrome with multiple visceral failure mimicking septic shock  Annals of Medicine and Surgery

An updated HACOR score for predicting the failure of noninvasive ventilation: a multicenter prospective observational study  Critical Care

Association between acute kidney injury and norepinephrine use following cardiac surgery: a retrospective propensity score-weighted analysis  Annals of Intensive Care

Association between nursing cost and patient outcomes in intensive care units: A retrospective cohort study of Belgian hospitals  Intensive and Critical Care Nursing

Association of multiple sclerosis with mortality in sepsis: a population-level analysis  Journal of Intensive Care

Association of Renin Angiotensin Aldosterone System Inhibitors and Outcomes of Hospitalized Patients With COVID-19  Critical Care Medicine

Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study  Intensive Care Medicine

Capnodynamic monitoring of lung volume and blood flow in response to increased positive end-expiratory pressure in moderate to severe COVID-19 pneumonia: an observational study  Critical Care

Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges  Annals of Intensive Care

Clustering identifies endotypes of traumatic brain injury in an intensive care cohort: a CENTER-TBI study  Critical Care

Complications of invasive mechanical ventilation in critically Ill Covid-19 patients – A narrative review  Annals of Medicine and Surgery

Composition and diversity analysis of the lung microbiome in patients with suspected ventilator-associated pneumonia  Critical Care

Determination of patients’ family members’ needs and related factors in the intensive care unit with visiting restrictions during the COVID-19 pandemic  Intensive and Critical Care Nursing

Dynamics of disease characteristics and clinical management of critically ill COVID-19 patients over the time course of the pandemic: an analysis of the prospective, international, multicentre RISC-19-ICU registry  Critical Care

E-CPR in Cardiac Arrest due to Accidental Hypothermia Using Intensivist Cannulators: A Case Series of Nine Consecutive Patients  Journal of Intensive Care Medicine

Effects of PEEP on regional ventilation-perfusion mismatch in the acute respiratory distress syndrome  Critical Care

Efficacy and Safety of Cisatracurium Compared to Vecuronium for Neuromuscular Blockade in Acute Respiratory Distress Syndrome  Journal of Intensive Care Medicine

Extended prone positioning duration for COVID-19-related ARDS: benefits and detriments  Critical Care

Feasibility and discriminatory value of tissue motion annular displacement in sepsis-induced cardiomyopathy: a single-center retrospective observational study  Critical Care

Fentanyl-Induced Rigid Chest Syndrome in Critically Ill Patients  Journal of Intensive Care Medicine

Fluid accumulation and major adverse kidney events in sepsis: a multicenter observational study  Annals of Intensive Care

Hospital Variation in Mortality and Ventilator Management among Mechanically Ventilated Patients with ARDS  Journal of Intensive Care Medicine

Impact of early mean arterial pressure level on severe acute kidney injury occurrence after out-of-hospital cardiac arrest  Annals of Intensive Care

Impact on 6-month outcomes of hospital trajectory in critically ill older patients: analysis of the ICE-CUB2 clinical trial  Annals of Intensive Care

Incidence and Outcomes of Cardiopulmonary Resuscitation in ICUs: Retrospective Cohort Analysis  Critical Care Medicine

Induction of severe hypoxemia and low lung recruitability for the evaluation of therapeutic ventilation strategies: a translational model of combined surfactant-depletion and ventilator-induced lung injury  Intensive Care Medicine Experimental

Influence of temperature management at 33 °C versus normothermia on survival in patients with vasopressor support after out-of-hospital cardiac arrest: a post hoc analysis of the TTM-2 trial  Critical Care

Intensive care unit versus high-dependency care unit admission on mortality in patients with septic shock: a retrospective cohort study using Japanese claims data  Journal of Intensive Care

Intracranial pressure: current perspectives on physiology and monitoring  Intensive Care Medicine

Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study  Critical Care

Invasive mechanical ventilation in patients with acute respiratory distress syndrome receiving extracorporeal support: a narrative review of strategies to mitigate lung injury  Anaesthesia

Is frailty associated with long-term survival, neurological function and patient-reported outcomes after in-hospital cardiac arrest? – A Swedish cohort study  Resuscitation

Lack of early etiologic investigations in young sudden cardiac death  Resuscitation

Long-term cognitive functioning is impaired in ICU-treated COVID-19 patients: a comprehensive controlled neuropsychological study  Critical Care

Long-term outcomes in patients who received veno-venous extracorporeal membrane oxygenation and renal replacement therapy: a retrospective cohort study  Annals of Intensive Care

Lung Ultrasound Signs to Diagnose and Discriminate Interstitial Syndromes in ICU Patients: A Diagnostic Accuracy Study in Two Cohorts  Critical Care Medicine

Neurologic manifestations of COVID-19 in critically ill patients: results of the prospective multicenter registry PANDEMIC  Critical Care

Neurological Pupil Index and its association with other prognostic tools after cardiac arrest: A post hoc analysis  Resuscitation

Noninvasive ventilation in COVID-19 patients aged ≥ 70 years—a prospective multicentre cohort study  Critical Care

Older age, delirium, dementia, frailty, and critical care: Care priorities  Intensive and Critical Care Nursing

Palliative care practice and moral distress during COVID-19 pandemic (PEOpLE-C19 study): a national, cross-sectional study in intensive care units in the Czech Republic  Critical Care

Paradoxical Positioning: Does “Head Up” Always Improve Mechanics and Lung Protection?  Critical Care Medicine

Paradoxical response to chest wall loading predicts a favorable mechanical response to reduction in tidal volume or PEEP  Critical Care

Patient-Important Outcomes Other Than Mortality in Contemporary ICU Trials: A Scoping Review  Critical Care Medicine

Peripheral tissue hypoperfusion predicts post intubation hemodynamic instability  Annals of Intensive Care

Persistent But Not Transient Acute Kidney Injury Was Associated With Lower Transplant-Free Survival in Patients With Acute Liver Failure: A Multicenter Cohort Study  Critical Care Medicine

Person-centred care among intensive care unit nurses: A cross-sectional study  Intensive and Critical Care Nursing

Pharmacotherapy consideration of thrombolytic medications in COVID-19-associated ARDS  Journal of Intensive Care

Poor physical recovery after critical illness: incidence, features, risk factors, pathophysiology, and evidence-based therapies  Current Opinion in Critical Care

Pre-Existing Right Ventricular Dysfunction as an Independent Risk Factor for Post Intubation Cardiac Arrest and Hemodynamic Instability in Critically Ill Patients: A Retrospective Observational Study  Journal of Intensive Care Medicine

Presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures   Intensive Care Medicine

Prognostic Implication of Pre-Cannulation Cardiac Arrest in Patients Undergoing Extracorporeal Membrane Oxygenation for the Management of Cardiogenic Shock  Journal of Intensive Care Medicine

Response to PEEP in COVID-19 ARDS patients with and without extracorporeal membrane oxygenation. A multicenter case–control computed tomography study  Critical Care

Risk factors for nosocomial infections and/or sepsis in adult burns patients: An integrative review  Intensive and Critical Care Nursing

Sepsis subphenotyping based on organ dysfunction trajectory  Critical Care

Serum Ferritin as a Predictor of Outcomes in Hospitalized Patients with Covid-19 Pneumonia  Journal of Intensive Care Medicine

The ABCDE approach to difficult weaning from venoarterial extracorporeal membrane oxygenation  Critical Care

The gut–liver axis in sepsis: interaction mechanisms and therapeutic potential  Critical Care

Tidal volume challenge to predict preload responsiveness in patients with acute respiratory distress syndrome under prone position  Critical Care

Tinzaparin—a review of its molecular profile, pharmacology, special properties, and clinical uses  European Journal of Clinical Pharmacology

Virtual reality in intensive care  Intensive Care Medicine



Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.