Critical Care Evidence Updates – July 2024

Randomised Controlled Trials

Cardiac index-guided therapy to maintain optimised postinduction cardiac index in high-risk patients having major open abdominal surgery: the multicentre randomised iPEGASUS trial  British Journal of Anaesthesia

Dexmedetomidine for Reducing Mortality in Patients With Septic Shock A Randomized Controlled Trial (DecatSepsis)  Chest

Effect of Bilateral Erector Spinae Plane Block versus Fentanyl Infusion on Postoperative Recovery in Cardiac Surgeries via Median Sternotomy: A Randomized Controlled Trial  Journal of Cardiothoracic and Vascular Anesthesia

Effect of Metagenomic Next-Generation Sequencing on Clinical Outcomes of Patients with Severe Community-Acquired Pneumonia in ICU: A Multicenter Randomized Controlled Trial  Chest

Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac Surgery  The ENGAGES-Canada Randomized Clinical Trial  JAMA

Exploring the effects of post operative hyperoxic intermittent stimuli on reticulocyte levels in cancer patients: a randomized controlled study  Journal of Anesthesia, Analgesia and Critical Care

Five sessions of hyperbaric oxygen for critically ill patients with COVID-19-induced ARDS: A randomised, open label, phase II trial  Respiratory Medicine

Fluid management for sepsis-induced hypotension in patients with advanced chronic kidney disease: a secondary analysis of the CLOVERS trial  Critical Care

High flow nasal cannula oxygen therapy versus non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease with acute-moderate hypercapnic respiratory failure: a randomized controlled non-inferiority trial  Critical Care

Impacts of three inspiratory muscle training programs on inspiratory muscles strength and endurance among intubated and mechanically ventilated patients with difficult weaning: a multicentre randomised controlled trial  Journal of Intensive Care

Low dose of morphine to relieve dyspnea in acute respiratory failure: the OpiDys double-blind randomized controlled trial  Respiratory Research

Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery: a post hoc analysis of a randomized clinical trial  Intensive Care Medicine

Personalised blood pressure management during major noncardiac surgery and postoperative neurocognitive disorders: a randomised trial  BJA Open

Plasma as endothelial rescue in septic shock: A randomized, phase 2a pilot trial  Transfusion

Preoperative high dose of dexamethasone in emergency laparotomy: randomized clinical trial  British Journal of Surgery

Relationship between microaspiration and ventilator-associated events: A post-hoc analysis of a randomized controlled trial  Intensive and Critical Care Nursing

Standard versus High Cardiopulmonary Bypass Flow Rate: A Randomized Controlled Subtrial Comparing Brain Injury Biomarker Release  Journal of Cardiothoracic and Vascular Anesthesia

Twenty percent human albumin solution fluid bolus administration therapy in patients after cardiac surgery-II: a multicentre randomised controlled trial  Intensive Care Medicine

 

Other Guidance/Reports

Cardiac arrest and cardiopulmonary resuscitation outcome reports: 2024 update of the Utstein Out-of-Hospital Cardiac Arrest Registry template  Resuscitation

Executive Summary—Society of Critical Care Medicine Guideline and American Society of Health-System Pharmacists for the Prevention of Stress-Related Gastrointestinal Bleeding in Critically Ill Adults  Critical Care Medicine

Management of Central Airway Obstruction. An American College of Chest Physicians Clinical Practice Guideline  Chest

Periprocedural Management and Multidisciplinary Care Pathways for Patients With Cardiac Implantable Electronic Devices: A Scientific Statement From the American Heart Association  Circulation

Reversal of direct oral anticoagulants: Guidance from the SSC of the ISTH: R1  Journal of Thrombosis and Haemostasis

Society of Critical Care Medicine and American Society of Health-System Pharmacists Guideline for the Prevention of Stress-Related Gastrointestinal Bleeding in Critically Ill Adults  Critical Care Medicine

Strategies to prevent blood loss and reduce transfusion in emergency general surgery, WSES-AAST consensus paper  World Journal of Emergency Surgery

The Surgical Infection Society Guidelines on the Management of Intra-Abdominal Infection: 2024 Update  Surgical Infections

 

Cochrane

Preoperative statin therapy for adults undergoing cardiac surgery

 

Primary Research

A multicentre point prevalence study of nocturnal hours awake and enteral pharmacological sleep aids in patients admitted to Australian and New Zealand intensive care units  Critical Care and Resuscitation

A proof of concept for microcirculation monitoring using machine learning based hyperspectral imaging in critically ill patients: a monocentric observational study  Critical Care

Absolute values of regional ventilation-perfusion mismatch in patients with ARDS monitored by electrical impedance tomography and the role of dead space and shunt compensation  Critical Care

Bloodstream infections among patients receiving therapeutic plasma exchanges in the intensive care unit: a 10 year multicentric study  Annals of Intensive Care

Calcium supplementation during trauma resuscitation: a propensity score-matched analysis from the TraumaRegister DGU^®  Critical Care

Can central venous pressure help identify acute right ventricular dysfunction in mechanically ventilated critically ill patients?  Annals of Intensive Care

Changes in quality of life 1 year after intensive care: a multicenter prospective cohort of ICU survivors  Critical Care

Clinical characteristics and outcomes of immunocompromised critically ill patients with cytomegalovirus end-organ disease: a multicenter retrospective cohort study  Critical Care

Critical thresholds of long-pressure reactivity index and impact of intracranial pressure monitoring methods in traumatic brain injury  Critical Care

Dual-Lumen Extracorporeal Membrane Oxygenation Cannulation Technique Using Only Transthoracic Echocardiography – A Case Series  Journal of Intensive Care Medicine

Dynamically Normalized Pupillometry for Detecting Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage  Critical Care Explorations

Early Fluid Is Less Fluid: Comparing Early Versus Late ICU Resuscitation in Severely Injured Trauma Patients  Critical Care Explorations

Early physical rehabilitation dosage in the intensive care unit associates with hospital outcomes after critical COVID-19  Critical Care

Effects of sodium-glucose transporter-2 inhibition on systemic hemodynamics, renal function, and intra-renal oxygenation in sepsis-associated acute kidney injury  Intensive Care Medicine Experimental

EPOS-OHCA: Early Predictors of Outcome and Survival after non-traumatic Out-of-Hospital Cardiac Arrest  Resuscitation Plus

Evaluating the Diagnostic Performance of Nasal Methicillin-Resistant Staphylococcus aureus Polymerase Chain Reaction in Hospital-Acquired Pneumonia Within the Intensive Care Unit. A Retrospective Study  Journal of Intensive Care Medicine

Heparin-Induced Thrombocytopenia in Patients Suffering Cardiogenic Shock  Critical Care Explorations

Immune profiling of critically ill patients with acute kidney injury during the first week after various types of injuries: the REALAKI study  Critical Care

Impact of a family support intervention on hospitalization costs and hospital readmissions among ICU patients at high risk of death or severe functional impairment  Annals of Intensive Care

Increasing plasma calprotectin (S100A8/A9) is associated with 12-month mortality and unfavourable functional outcome in critically ill COVID-19 patients  Journal of Intensive Care

Influenza-associated and COVID-19-associated pulmonary aspergillosis in critically ill patients  The Lancet Respiratory Medicine

Integrated clustering of multiple immune marker trajectories reveals different immunotypes in severely injured patients  Critical Care

Long term cognitive dysfunction among critical care survivors: associated factors and quality of life—a multicenter cohort study  Annals of Intensive Care

Lung ultrasound among Expert operator’S: ScOring and iNter-rater reliability analysis (LESSON study) a secondary COWS study analysis from ITALUS group  Journal of Anesthesia, Analgesia and Critical Care

Midline Catheters as an Alternative for Central Venous Catheters in Venous Oxygen Saturation Monitoring: A Single Center Experience  Journal of Intensive Care Medicine

Mitochondrial oxygen tension in critically ill patients receiving red blood cell transfusions: a multicenter observational cohort study  Intensive Care Medicine Experimental

Normal saline versus Ringer’s solution and critical-illness mortality in acute pancreatitis: a nationwide inpatient database study  Journal of Intensive Care

Nutritional therapy for the prevention of post-intensive care syndrome  Journal of Intensive Care

Operator independent continuous ultrasound monitoring of diaphragm excursion predicts successful weaning from mechanical ventilation: a prospective observational study  Critical Care

Parameters Predictive of Propofol-Associated Acute Pancreatitis in Critically Ill Patients with COVID-19 Pneumonia: A Retrospective Cohort Study  Journal of Intensive Care Medicine

Performance and impact of rapid multiplex PCR on diagnosis and treatment of ventilated hospital-acquired pneumonia in patients with extended-spectrum β-lactamase-producing Enterobacterales rectal carriage  Annals of Intensive Care

Post-intensive care syndrome screening: a French multicentre survey  Annals of Intensive Care

Predictive enrichment for the need of renal replacement in sepsis-associated acute kidney injury: combination of furosemide stress test and urinary biomarkers TIMP-2 and IGFBP-7  Annals of Intensive Care

Prioritising deteriorating patients using time-to-event analysis: prediction model development and internal–external validation  Critical Care

Prognostic value of serial (1,3)-β-d-glucan measurements in ICU patients with invasive candidiasis  Critical Care

Prolonged Fatigue and Mental Health Challenges in Critical COVID-19 Survivors  Journal of Intensive Care Medicine

Pulmonary herpes simplex virus and cytomegalovirus in patients with acute respiratory distress syndrome related to COVID-19  Intensive Care Medicine

Risk factors for colonisation by Multidrug-Resistant bacteria in critical care units  Intensive and Critical Care Nursing

Stepwise implementation of prevention strategies and their impact on ventilator-associated pneumonia incidence: A 13-Year observational surveillance study  Intensive and Critical Care Nursing

The impact of norepinephrine dose reporting heterogeneity on mortality prediction in septic shock patients  Critical Care

The paradox of workplace violence in the intensive care unit: a focus group study  Critical Care

Therapeutic impact of basic critical care echocardiography performed by residents after limited training  Annals of Intensive Care

Unravelling the complexity of ventilator-associated pneumonia: a systematic methodological literature review of diagnostic criteria and definitions used in clinical research  Critical Care

Upper gastrointestinal bleeding on veno-arterial extracorporeal membrane oxygenation support  Annals of Intensive Care

 

Metadata

Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash