Critical Care Evidence Updates – June 2023

Randomised Controlled Trials

Atrial natriuretic peptide in the prevention of acute renal dysfunction after heart transplantation—a randomized placebo-controlled double-blind trial  Acta Anaesthesiologica Scandinavica

Balanced crystalloid solution versus saline in deceased donor kidney transplantation (BEST-Fluids): a pragmatic, double-blind, randomised, controlled trial  The Lancet

Comparison of Noninvasive Mechanical Ventilation With High-Flow Nasal Cannula, Face-Mask, and Helmet in Hypoxemic Respiratory Failure in Patients With COVID-19: A Randomized Controlled Trial  Critical Care Medicine

Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis – The MERCY Randomized Clinical Trial  JAMA

Delirium in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: a multicentre randomised trial  British Journal of Anaesthesia

Desmopressin for patients with spontaneous intracerebral haemorrhage taking antiplatelet drugs (DASH): a UK-based, phase 2, randomised, placebo-controlled, multicentre feasibility trial  The Lancet Neurology

Direct assessment of microcirculation in shock: a randomized-controlled multicenter study  Intensive Care Medicine

Discontinuation of Universal Admission Testing for SARS-CoV-2 and Hospital-Onset COVID-19 Infections in England and Scotland  JAMA Internal Medicine

Effect of a low versus intermediate tidal volume strategy on pulmonary complications in patients at risk of acute respiratory distress syndrome—a randomized clinical trial  Frontiers in Medicine

Effect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure  NEJM

Effect of propranolol and clonidine after severe traumatic brain injury: a pilot randomized clinical trial  Critical Care

Effect of Structural Moral Case Deliberation on Burnout Symptoms, Moral Distress, and Team Climate in ICU Professionals: A Parallel Cluster Randomized Trial  Critical Care Medicine

Effect of the P-selectin Inhibitor Crizanlizumab on Survival Free of Organ Support in Patients Hospitalized for COVID-19: A Randomized Controlled Trial  Circulation

Effect of weight-adjusted intermediate-dose versus fixed-dose prophylactic anticoagulation with low-molecular-weight heparin on venous thromboembolism among noncritically and critically ill patients with COVID-19: the COVI-DOSE trial, a multicenter, randomised, open-label, phase 4 trial  eClinicalMedicine

Effectiveness of Lumbar Cerebrospinal Fluid Drain Among Patients With Aneurysmal Subarachnoid Hemorrhage – A Randomized Clinical Trial  JAMA Neurology

Efficacy and Safety of Ciprofol Sedation in ICU Patients Undergoing Mechanical Ventilation: A Multicenter, Single-Blind, Randomized, Noninferiority Trial  Critical Care Medicine

Efficacy and safety of intravenous imatinib in COVID-19 ARDS: a randomized, double-blind, placebo-controlled clinical trial  Critical Care

Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial  The Lancet Respiratory Medicine

Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest  NEJM

Modifications of lung microbiota structure in traumatic brain injury ventilated patients according to time and enteral feeding formulas: a prospective randomized study  Critical Care

Phase 2, randomized, double-blind, placebo-controlled multi-center trial of the clinical and biological effects of anti-CD14 treatment in hospitalized patients with COVID-19 pneumonia  eBioMedicine

Piperacillin-Tazobactam Versus Anti-Pseudomonal Cephalosporins and Renal and Neurologic Outcomes in Critically Ill Adults: A Secondary Analysis of the SMART Trial  Journal of Intensive Care Medicine

Polymyxin B therapy based on therapeutic drug monitoring in carbapenem-resistant organisms sepsis: the PMB-CROS randomized clinical trial  Critical Care

Prone position versus usual care in hypoxemic COVID-19 patients in medical wards: a randomised controlled trial  Critical Care

Propofol Versus Remimazolam on Cognitive Function, Hemodynamics, and Oxygenation During One-Lung Ventilation in Older Patients Undergoing Pulmonary Lobectomy: A Randomized Controlled Trial  Journal of Cardiothoracic and Vascular Anesthesia

Sodium Bicarbonate for Metabolic Acidosis in the ICU: Results of a Pilot Randomized Double-Blind Clinical Trial  Critical Care Medicine

Targeted therapy using polymyxin B hemadsorption in patients with sepsis: a post-hoc analysis of the JSEPTIC-DIC study and the EUPHRATES trial  Critical Care

The Effect of Ketamine versus Etomidate for Rapid Sequence Intubation on Maximum SOFA Score: A Randomized Clinical Trial  The Journal of Emergency Medicine

The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial  The Lancet

Thiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-Controlled Trial  American Journal of Respiratory and Critical Care Medicine

Transplantation Outcomes with Donor Hearts after Circulatory Death  NEJM

Venoarterial extracorporeal membrane oxygenation or standard care in patients with cardiogenic shock complicating acute myocardial infarction: the multicentre, randomised EURO SHOCK trial  EuroIntervention

Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults  NEJM


COVID-19 rapid guideline: managing COVID-19 NG191

Other Guidance/Reports

A Multi-Hospital Survey of Current Practices for Supporting Recovery From Sepsis  Critical Care Explorations

AASLD Practice Guidance on the Use of TIPS, Variceal Embolization, and Retrograde Transvenous Obliteration in the Management of Variceal Hemorrhage  Hepatology

Caring for Patients With Acute Respiratory Distress Syndrome Summary of the 2023 ESICM Practice Guidelines  JAMA

Consensus Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS®) Society Recommendations Part 2—Emergency Laparotomy: Intra- and Postoperative Care  World Journal of Surgery

EASL Clinical Practice Guidelines on acute-on-chronic liver failure  Journal of Hepatology

Enhanced Recovery After Surgery (ERAS®) Society Consensus Guidelines for Emergency Laparotomy Part 3: Organizational Aspects and General Considerations for Management of the Emergency Laparotomy Patient  World Journal of Surgery

ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies  Intensive Care Medicine

Guidelines for Neuroprognostication in Comatose Adult Survivors of Cardiac Arrest  Neurocritical Care

Health Literacy and Systemic Racism—Using Clear Communication to Reduce Health Care Inequities  JAMA Internal Medicine

IDSA 2023 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections  IDSA

Step by step daily management of short-term mechanical circulatory support for cardiogenic shock in adults in the intensive cardiac care unit: a clinical consensus statement of the Association for Acute CardioVascular Care of the European Society of Cardiology SC, the European Society of Intensive Care Medicine, the European branch of the Extracorporeal Life Support Organization, and the European Association for Cardio-Thoracic Surgery  European Heart Journal Acute Cardiovascular Care


Interleukin‐6 blocking agents for treating COVID‐19: a living systematic review

Medically assisted hydration for adults receiving palliative care

Primary Research

ABO Blood Group and Bleeding and Survival in VA-ECMO Patients  Journal of Intensive Care Medicine

Analysis of Protein Biomarkers From Hospitalized COVID-19 Patients Reveals Severity-Specific Signatures and Two Distinct Latent Profiles With Differential Responses to Corticosteroids  Critical Care Medicine

Assessment of the relative benefits of monotherapy and combination therapy approaches to the treatment of hospital-acquired Stenotrophomonas maltophilia pneumonia: a multicenter, observational, real-world study  Annals of Intensive Care

Association of Hospital Mortality With Initiation of Mechanical Ventilation on a Weekend: A Retrospective Cohort Study  Journal of Intensive Care Medicine

Body temperature and infection in critically ill patients on continuous kidney replacement therapy  BMC Nephrology

COVID-19 Infection Is Associated With Increased In-Hospital Mortality and Complications in Patients With Acute Heart Failure: Insight From National Inpatient Sample (2020)  Journal of Intensive Care Medicine

Efficacy of endotracheal tube clamping to prevent positive airways pressure loss and pressure behavior after reconnection: a bench study  Intensive Care Medicine Experimental

Evaluation of the Impact of ABCDEF Bundle Compliance Rates on Postintensive Care Syndrome: A Secondary Analysis Study  Critical Care Medicine

Extracorporeal hemoadsorption in critically ill COVID-19 patients on VV ECMO: the CytoSorb therapy in COVID-19 (CTC) registry  Critical Care

Factors associated with circulatory death after out-of-hospital cardiac arrest: a population-based cluster analysis  Annals of Intensive Care

Feasibility of mobilisation in ICU: a multi-centre point prevalence study of mobility practices in the UK  Critical Care

Fibrotic-Like Pulmonary Radiographic Patterns Are Not Associated With Adverse Outcomes in COVID-19 Chronic Critical Illness  Critical Care Medicine

Giving a voice to patients at high risk of dying in the intensive care unit: a multiple source approach  Intensive Care Medicine

In an endotoxaemic model, antibiotic clearance can be affected by different central venous catheter positions, during renal replacement therapy  Intensive Care Medicine Experimental

Influence of gender on age-associated in-hospital mortality in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study  Critical Care

Inhaled nitric oxide in patients with acute respiratory distress syndrome caused by COVID-19: treatment modalities, clinical response, and outcomes  Annals of Intensive Care

Insulin therapy and blood glucose management in critically ill patients: a 1-day cross-sectional observational study in 69 French intensive care units  Annals of Intensive Care

International Analgesia and Sedation Weaning and Withdrawal Practices in Critically Ill Adults: The Adult Iatrogenic Withdrawal Study in the ICU  Critical Care Medicine

International survey of antibiotic dosing and monitoring in adult intensive care units  Critical Care

Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock  Intensive Care Medicine

Modified subcostal approach to anterior quadratus lumborum block for managing postoperative pain in patients undergoing open nephrectomy  Journal of Anesthesia, Analgesia and Critical Care

Noninvasive Cardiac Output Monitoring (NICOM) in the Critically Ill Patient Undergoing Endotracheal Intubation: A Prospective Observational Study  Journal of Intensive Care Medicine

Pharmacokinetic analysis of vilobelimab, anaphylatoxin C5a and antidrug antibodies in PANAMO: a phase 3 study in critically ill,  invasively mechanically ventilated COVID-19 patients  Intensive Care Medicine Experimental

Phase I pilot safety and feasibility of a novel restraint device for critically ill patients requiring mechanical ventilation  Journal of the Intensive Care Society

Prevalence of systemic venous congestion assessed by Venous Excess Ultrasound Grading System (VExUS) and association with acute kidney injury in a general ICU cohort: a prospective multicentric study  Critical Care

Prevalence, reasons, and timing of decisions to withhold/withdraw life-sustaining therapy for out-of-hospital cardiac arrest patients with extracorporeal cardiopulmonary resuscitation  Critical Care

Probiotic-Associated Central Venous Catheter Bloodstream Infections Lead to Increased Mortality in the ICU  Critical Care Medicine

Prognostic value of respiratory compliance course on mortality in COVID-19 patients with vv-ECMO  Annals of Intensive Care

Pursuing the Real Vancomycin Clearance during Continuous Renal Replacement Therapy in Intensive Care Unit Patients: Is There Adequate Target Attainment?  Blood Purification

Reduced anticoagulation strategy is associated with a lower incidence of intracerebral hemorrhage in COVID-19 patients on extracorporeal membrane oxygenation  Intensive Care Medicine Experimental

Relationship between COVID-19 and ICU-acquired colonization and infection related to multidrug-resistant bacteria: a prospective multicenter before-after study  Intensive Care Medicine

The Effect of Fluid Resuscitation Timing in Early Sepsis Resuscitation  Journal of Intensive Care Medicine

The future of artificial intelligence in intensive care: moving from predictive to actionable AI  Intensive Care Medicine

The oxygen reactivity index indicates disturbed local perfusion regulation after aneurysmal subarachnoid hemorrhage: an observational cohort study  Critical Care

The Relationship Between Hospital Capability and Mortality in Sepsis: Development of a Sepsis-Related Hospital Capability Index  Critical Care Medicine

The use of neurone specific enolase to prognosticate neurological recovery and long term neurological outcomes in OOHCA patients  Journal of the Intensive Care Society

Tidal lung hysteresis to interpret PEEP-induced changes in compliance in ARDS patients  Critical Care

Tocilizumab Associated With Survival in Patients Hospitalized for COVID-19 Acute Respiratory Distress Syndrome and Low Urine Output  Journal of Intensive Care Medicine

Unmeasured Organic Anions as Predictors of Clinical Outcomes in Lactic Acidosis due to Sepsis  Journal of Intensive Care Medicine

Vagueness in Goals-of-Care Conferences for Critically Ill Patients: Types of Hedge Language Used by Physicians  Critical Care Medicine


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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