Critical Care Evidence Updates – June 2023
Randomised Controlled Trials
Atrial natriuretic peptide in the prevention of acute renal dysfunction after heart transplantation—a randomized placebo-controlled double-blind trial Acta Anaesthesiologica Scandinavica
Comparison of Noninvasive Mechanical Ventilation With High-Flow Nasal Cannula, Face-Mask, and Helmet in Hypoxemic Respiratory Failure in Patients With COVID-19: A Randomized Controlled Trial Critical Care Medicine
Delirium in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: a multicentre randomised trial British Journal of Anaesthesia
Desmopressin for patients with spontaneous intracerebral haemorrhage taking antiplatelet drugs (DASH): a UK-based, phase 2, randomised, placebo-controlled, multicentre feasibility trial The Lancet Neurology
Direct assessment of microcirculation in shock: a randomized-controlled multicenter study Intensive Care Medicine
Discontinuation of Universal Admission Testing for SARS-CoV-2 and Hospital-Onset COVID-19 Infections in England and Scotland JAMA Internal Medicine
Effect of a low versus intermediate tidal volume strategy on pulmonary complications in patients at risk of acute respiratory distress syndrome—a randomized clinical trial Frontiers in Medicine
Effect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure NEJM
Effect of propranolol and clonidine after severe traumatic brain injury: a pilot randomized clinical trial Critical Care
Effect of Structural Moral Case Deliberation on Burnout Symptoms, Moral Distress, and Team Climate in ICU Professionals: A Parallel Cluster Randomized Trial Critical Care Medicine
Effectiveness of Lumbar Cerebrospinal Fluid Drain Among Patients With Aneurysmal Subarachnoid Hemorrhage – A Randomized Clinical Trial JAMA Neurology
Efficacy and Safety of Ciprofol Sedation in ICU Patients Undergoing Mechanical Ventilation: A Multicenter, Single-Blind, Randomized, Noninferiority Trial Critical Care Medicine
Efficacy and safety of intravenous imatinib in COVID-19 ARDS: a randomized, double-blind, placebo-controlled clinical trial Critical Care
Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial The Lancet Respiratory Medicine
Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest NEJM
Piperacillin-Tazobactam Versus Anti-Pseudomonal Cephalosporins and Renal and Neurologic Outcomes in Critically Ill Adults: A Secondary Analysis of the SMART Trial Journal of Intensive Care Medicine
Prone position versus usual care in hypoxemic COVID-19 patients in medical wards: a randomised controlled trial Critical Care
Propofol Versus Remimazolam on Cognitive Function, Hemodynamics, and Oxygenation During One-Lung Ventilation in Older Patients Undergoing Pulmonary Lobectomy: A Randomized Controlled Trial Journal of Cardiothoracic and Vascular Anesthesia
Sodium Bicarbonate for Metabolic Acidosis in the ICU: Results of a Pilot Randomized Double-Blind Clinical Trial Critical Care Medicine
The Effect of Ketamine versus Etomidate for Rapid Sequence Intubation on Maximum SOFA Score: A Randomized Clinical Trial The Journal of Emergency Medicine
Thiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-Controlled Trial American Journal of Respiratory and Critical Care Medicine
Transplantation Outcomes with Donor Hearts after Circulatory Death NEJM
Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults NEJM
NICE
COVID-19 rapid guideline: managing COVID-19 NG191
Other Guidance/Reports
A Multi-Hospital Survey of Current Practices for Supporting Recovery From Sepsis Critical Care Explorations
Consensus Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS®) Society Recommendations Part 2—Emergency Laparotomy: Intra- and Postoperative Care World Journal of Surgery
EASL Clinical Practice Guidelines on acute-on-chronic liver failure Journal of Hepatology
Enhanced Recovery After Surgery (ERAS®) Society Consensus Guidelines for Emergency Laparotomy Part 3: Organizational Aspects and General Considerations for Management of the Emergency Laparotomy Patient World Journal of Surgery
ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies Intensive Care Medicine
Guidelines for Neuroprognostication in Comatose Adult Survivors of Cardiac Arrest Neurocritical Care
Health Literacy and Systemic Racism—Using Clear Communication to Reduce Health Care Inequities JAMA Internal Medicine
IDSA 2023 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections IDSA
Step by step daily management of short-term mechanical circulatory support for cardiogenic shock in adults in the intensive cardiac care unit: a clinical consensus statement of the Association for Acute CardioVascular Care of the European Society of Cardiology SC, the European Society of Intensive Care Medicine, the European branch of the Extracorporeal Life Support Organization, and the European Association for Cardio-Thoracic Surgery European Heart Journal Acute Cardiovascular Care
Cochrane
Interleukin‐6 blocking agents for treating COVID‐19: a living systematic review
Medically assisted hydration for adults receiving palliative care
Primary Research
ABO Blood Group and Bleeding and Survival in VA-ECMO Patients Journal of Intensive Care Medicine
Analysis of Protein Biomarkers From Hospitalized COVID-19 Patients Reveals Severity-Specific Signatures and Two Distinct Latent Profiles With Differential Responses to Corticosteroids Critical Care Medicine
Assessment of the relative benefits of monotherapy and combination therapy approaches to the treatment of hospital-acquired Stenotrophomonas maltophilia pneumonia: a multicenter, observational, real-world study Annals of Intensive Care
Association of Hospital Mortality With Initiation of Mechanical Ventilation on a Weekend: A Retrospective Cohort Study Journal of Intensive Care Medicine
Body temperature and infection in critically ill patients on continuous kidney replacement therapy BMC Nephrology
COVID-19 Infection Is Associated With Increased In-Hospital Mortality and Complications in Patients With Acute Heart Failure: Insight From National Inpatient Sample (2020) Journal of Intensive Care Medicine
Efficacy of endotracheal tube clamping to prevent positive airways pressure loss and pressure behavior after reconnection: a bench study Intensive Care Medicine Experimental
Evaluation of the Impact of ABCDEF Bundle Compliance Rates on Postintensive Care Syndrome: A Secondary Analysis Study Critical Care Medicine
Extracorporeal hemoadsorption in critically ill COVID-19 patients on VV ECMO: the CytoSorb therapy in COVID-19 (CTC) registry Critical Care
Factors associated with circulatory death after out-of-hospital cardiac arrest: a population-based cluster analysis Annals of Intensive Care
Feasibility of mobilisation in ICU: a multi-centre point prevalence study of mobility practices in the UK Critical Care
Fibrotic-Like Pulmonary Radiographic Patterns Are Not Associated With Adverse Outcomes in COVID-19 Chronic Critical Illness Critical Care Medicine
Giving a voice to patients at high risk of dying in the intensive care unit: a multiple source approach Intensive Care Medicine
In an endotoxaemic model, antibiotic clearance can be affected by different central venous catheter positions, during renal replacement therapy Intensive Care Medicine Experimental
Inhaled nitric oxide in patients with acute respiratory distress syndrome caused by COVID-19: treatment modalities, clinical response, and outcomes Annals of Intensive Care
Insulin therapy and blood glucose management in critically ill patients: a 1-day cross-sectional observational study in 69 French intensive care units Annals of Intensive Care
International Analgesia and Sedation Weaning and Withdrawal Practices in Critically Ill Adults: The Adult Iatrogenic Withdrawal Study in the ICU Critical Care Medicine
International survey of antibiotic dosing and monitoring in adult intensive care units Critical Care
Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock Intensive Care Medicine
Modified subcostal approach to anterior quadratus lumborum block for managing postoperative pain in patients undergoing open nephrectomy Journal of Anesthesia, Analgesia and Critical Care
Noninvasive Cardiac Output Monitoring (NICOM) in the Critically Ill Patient Undergoing Endotracheal Intubation: A Prospective Observational Study Journal of Intensive Care Medicine
Pharmacokinetic analysis of vilobelimab, anaphylatoxin C5a and antidrug antibodies in PANAMO: a phase 3 study in critically ill, invasively mechanically ventilated COVID-19 patients Intensive Care Medicine Experimental
Phase I pilot safety and feasibility of a novel restraint device for critically ill patients requiring mechanical ventilation Journal of the Intensive Care Society
Probiotic-Associated Central Venous Catheter Bloodstream Infections Lead to Increased Mortality in the ICU Critical Care Medicine
Prognostic value of respiratory compliance course on mortality in COVID-19 patients with vv-ECMO Annals of Intensive Care
Pursuing the Real Vancomycin Clearance during Continuous Renal Replacement Therapy in Intensive Care Unit Patients: Is There Adequate Target Attainment? Blood Purification
Reduced anticoagulation strategy is associated with a lower incidence of intracerebral hemorrhage in COVID-19 patients on extracorporeal membrane oxygenation Intensive Care Medicine Experimental
Relationship between COVID-19 and ICU-acquired colonization and infection related to multidrug-resistant bacteria: a prospective multicenter before-after study Intensive Care Medicine
The Effect of Fluid Resuscitation Timing in Early Sepsis Resuscitation Journal of Intensive Care Medicine
The future of artificial intelligence in intensive care: moving from predictive to actionable AI Intensive Care Medicine
The Relationship Between Hospital Capability and Mortality in Sepsis: Development of a Sepsis-Related Hospital Capability Index Critical Care Medicine
The use of neurone specific enolase to prognosticate neurological recovery and long term neurological outcomes in OOHCA patients Journal of the Intensive Care Society
Tidal lung hysteresis to interpret PEEP-induced changes in compliance in ARDS patients Critical Care
Tocilizumab Associated With Survival in Patients Hospitalized for COVID-19 Acute Respiratory Distress Syndrome and Low Urine Output Journal of Intensive Care Medicine
Unmeasured Organic Anions as Predictors of Clinical Outcomes in Lactic Acidosis due to Sepsis Journal of Intensive Care Medicine
Vagueness in Goals-of-Care Conferences for Critically Ill Patients: Types of Hedge Language Used by Physicians Critical Care Medicine
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash
