Critical Care Evidence Updates – June 2024

Randomised Controlled Trials

A Randomized Trial of Intravenous Amino Acids for Kidney Protection  NEJM

Albumin Versus Balanced Crystalloid for the Early Resuscitation of Sepsis: An Open Parallel-Group Randomized Feasibility Trial. The ABC-Sepsis Trial  Critical Care Medicine

Analgesic Effect and Sleep Quality of Low-Dose Dexmedetomidine in Cardiac Surgical Patients After Ultrafast-Track Extubation: A Randomized Clinical Trial  Journal of Cardiothoracic and Vascular Anesthesia

Burr-hole drainage with or without irrigation for chronic subdural haematoma (FINISH): a Finnish, nationwide, parallel-group, multicentre, randomised, controlled, non-inferiority trial  The Lancet

Comparative efficacy of peptide-based versus standard polymeric enteral nutrition in ICU patients at high nutritional risk: a multicenter randomized controlled trial  Scientific Reports

Comparing BIS Monitoring vs. Clinical Assessment for Deep Sedation in the ICU: Effects on Delirium Reduction and Sedative Drug Doses – A randomized trial  Chest Journal

Comparison of Catheter Malposition Between Left and Right Ultrasound-Guided Infraclavicular Subclavian Venous Catheterizations: A Randomized Controlled Trial  Critical Care Medicine

Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis – The BLING III Randomized Clinical Trial  JAMA

Dapagliflozin for Critically Ill Patients With Acute Organ Dysfunction – The DEFENDER Randomized Clinical Trial  JAMA

Early In-Bed Cycle Ergometry in Mechanically Ventilated Patients  NEJM Evidence

Effect of coadministration of 10 mg/kg calcium chloride and neostigmine on extubation time: A randomized controlled trial  Revista Española de Anestesiología y Reanimación (English Edition)

Effect of volatile versus propofol anaesthesia on major complications and mortality after cardiac surgery: a multicentre randomised trial  British Journal of Anaesthesia

Effects of balanced versus saline-based solutions on acute kidney injury in off-pump coronary artery bypass surgery: A randomized controlled trial  Journal of Cardiothoracic and Vascular Anesthesia

Esketamine use for primary intelligent analgesia in adults with severe burns: A double-blind randomized trial with effects on analgesic efficacy, gastrointestinal function and mental state  Burns

Impact of early high protein intake in critically ill patients: a randomized controlled trial  Nutrition & Metabolism

Impact of extended lung protection during mechanical ventilation on lung recovery in patients with COVID-19 ARDS: a phase II randomized controlled trial  Annals of Intensive Care

Intravenous magnesium sulfate improves orotracheal intubation conditions: A randomized clinical trial  Trends in Anaesthesia and Critical Care

Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury  NEJM

Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 InfectionThe STOP-PASC Randomized Clinical Trial  JAMA Internal Medicine

No drains versus drains after perforated peptic ulcer repair: A randomized controlled trail  European Journal of Trauma and Emergency Surgery

Povidone Iodine vs Chlorhexidine Gluconate in Alcohol for Preoperative Skin Antisepsis – A Randomized Clinical Trial  JAMA

Role of low-pressure negative pleural suction in patients with thoracic trauma – a randomized controlled trial  European Journal of Trauma and Emergency Surgery

Standard vs. carbone dioxide adapted kidney replacement therapy in hypercapnic ARDS patients: a randomized controlled pilot trial (BigBIC)  Critical Care

Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation  NEJM

Volume control strategy and patient survival in sepsis-associated acute kidney injury receiving continuous renal replacement therapy: a randomized controlled trial with secondary analysis  Scientific Reports

 

Other Guidance/Reports

An ISHLT consensus statement on strategies to prevent and manage hemocompatibility related adverse events in patients with a durable, continuous-flow ventricular assist device  The Journal of Heart and Lung Transplantation

Fever and infections in surgical intensive care: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document  Trauma Surgery & Acute Care Open

Guidance for clinical practice using emergency and point-of-care ultrasonography  Acute Medicine & Surgery

Improving Outcomes After Post–Cardiac Arrest Brain Injury: A Scientific Statement From the International Liaison Committee on Resuscitation  Resuscitation

Intra-abdominal infections survival guide: a position statement by the Global Alliance For Infections In Surgery  World Journal of Emergency Surgery

Management of intra-abdominal infections: recommendations by the Italian council for the optimization of antimicrobial use  World Journal of Emergency Surgery

PeriOperative Quality Initiative (POQI) international consensus statement on perioperative arterial pressure management  British Journal of Anaesthesia

Spanish Society of Anesthesiology, Reanimation and Pain Therapy (SEDAR), Spanish Society of Emergency and Emergency Medicine (SEMES) and Spanish Society of Otolaryngology, Head and Neck Surgery (SEORL-CCC) Guideline for difficult airway management. Part I  Revista Española de Anestesiología y Reanimación (English Edition)

Spanish Society of Anesthesiology, Reanimation and Pain Therapy (SEDAR), Spanish Society of Emergency and Emergency Medicine (SEMES) and Spanish Society of Otolaryngology, Head and Neck Surgery (SEORL-CCC) Guideline for difficult airway management. Part II  Revista Española de Anestesiología y Reanimación (English Edition)

Surgical and procedural antibiotic prophylaxis in the surgical ICU: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document  Trauma Surgery & Acute Care Open

Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association  Circulation

Ventricular septal defect complicating acute myocardial infarction: diagnosis and management. A Clinical Consensus Statement of the Association for Acute CardioVascular Care (ACVC) of the ESC, the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC and the ESC Working Group on Cardiovascular Surgery  European Heart Journal

 

Primary Research

A Retrospective Cohort Analysis of Analgosedation Requirements in COVID-19 Compared to Non-COVID-19 Extracorporeal Membrane Oxygenation Patients  Journal of Intensive Care Medicine

A Review of Chlorhexidine Oral Care in Patients Receiving Mechanical Ventilation  Critical Care Nurse

Advanced waveform analysis of diaphragm surface EMG allows for continuous non-invasive assessment of respiratory effort in critically ill patients at different PEEP levels  Critical Care

Association Between Dyscapnia, Ventilatory Variables, and Mortality in Patients With Acute Respiratory Distress Syndrome—A Retrospective Cohort Study  Journal of Intensive Care Medicine

Association between hyperglycemia at ICU admission and postoperative acute kidney injury in patients undergoing cardiac surgery: Analysis of the MIMIC-IV database  Journal of Intensive Medicine

Beyond Unplanned ICU Transfers: Linking a Revised Definition of Deterioration to Patient Outcomes  Critical Care Medicine

Clinicians’ Use of Choice Framing in ICU Family Meetings  Critical Care Medicine

Consumptive coagulopathy: how low-dose unfractionated heparin can prevent bleeding complications during extracorporeal life support  Intensive Care Medicine

Determining prognostic indicator for anticoagulant therapy in sepsis-induced disseminated intravascular coagulation  Journal of Intensive Care

Development and Validation of a Prediction Model for 1-Year Mortality in Patients With a Hematologic Malignancy Admitted to the ICU  Critical Care Explorations

Early and late effects of volatile sedation with sevoflurane on respiratory mechanics of critically ill COPD patients  Annals of Intensive Care

Effect of high-flow nasal cannula at different flow rates on diaphragmatic function in subjects recovering from an acute exacerbation of COPD: a physiological prospective pilot study  Journal of Anesthesia, Analgesia and Critical Care

Empirical antifungal therapy for health care-associated intra-abdominal infection: a retrospective, multicentre and comparative study  Annals of Intensive Care

Extracorporeal Membrane Oxygenation and Reperfusion Strategies in High-Risk Pulmonary Embolism Hospitalizations  Critical Care Medicine

Haemoglobin values, transfusion practices, and long-term outcomes in critically ill patients with traumatic brain injury: a secondary analysis of CENTER-TBI  Critical Care

Helmet c-PAP Versus NIPPV in Association with Early Respiratory Physiotherapy and Mobilization for Treating SARS-CoV-2 ARDS: A Case–control Prospective Single-center Study  Journal of Intensive Care Medicine

Hospital and regional variations in intensive care unit admission for patients with invasive mechanical ventilation  Journal of Intensive Care

Immunosuppression at ICU admission is not associated with a higher incidence of ICU-acquired bacterial bloodstream infections: the COCONUT study  Annals of Intensive Care

Impact of intensive prone position therapy on outcomes in intubated patients with ARDS related to COVID-19  Annals of Intensive Care

Increasing the Volume of Delivered Enteral Feeds Using a Volume-Based Feeding Protocol in a Neuroscience Intensive Care Unit  Critical Care Nurse

Independent Risk Factors for Prolonged Tube Feeding After Endotracheal Intubation and Ventilation  Journal of Intensive Care Medicine

Is admission neutrophil-to-lymphocyte ratio an outcome predictor in critically ill multiple trauma patients? A retrospective single-centre cross-sectional study  Trauma

Low-flow time and outcomes in hypothermic cardiac arrest patients treated with extracorporeal cardiopulmonary resuscitation: a secondary analysis of a multi-center retrospective cohort study  Journal of Intensive Care

Maladaptive personality traits are associated with burnout risk in Italian anesthesiologists and intensivists: a secondary analysis from a cross-sectional study  Journal of Anesthesia, Analgesia and Critical Care

Management of severe acute respiratory distress syndrome in Australia and New Zealand (SAGE-ANZ): An observational study  Critical Care and Resuscitation

Nucleated red blood cells as a prognostic marker for mortality in patients with SARS-CoV-2-induced ARDS: an observational study  Journal of Anesthesia, Analgesia and Critical Care

Occurrence of pendelluft during ventilator weaning with T piece correlated with increased mortality in difficult-to-wean patients   Journal of Intensive Care

Optimal Prone Position Duration in Patients With ARDS Due to COVID-19: The Omelette Pilot Trial  Respiratory Care

Pain and psychopathology after intensive care unit admission  Anaesthesia and Intensive Care

Pneumocystis pneumonia in intensive care: clinical spectrum, prophylaxis patterns, antibiotic treatment delay impact, and role of corticosteroids. A French multicentre prospective cohort study  Intensive Care Medicine

Potential risk factors for reduced quality of life and increased health care utilization in ARDS survivors: results from the multicenter cohort study DACAPO  Critical Care

Quantitative EEG reactivity induced by electrical stimulation predicts good outcome in comatose patients after cardiac arrest  Annals of Intensive Care

Reducing Tracheostomy-Related Acquired Pressure Injury by Flipping the Ventilator Circuit Position Study  Critical Care Explorations

Refeeding syndrome risk at ICU admission is an independent predictor of ICU readmission but it is not associated with mortality or length of stay in critically ill patients  Intensive and Critical Care Nursing

Reliability and reproducibility of the venous excess ultrasound (VExUS) score, a multi-site prospective study: validating a novel ultrasound technique for comprehensive assessment of venous congestion  Critical Care

Sex differences in the SOFA score of ICU patients with sepsis or septic shock: a nationwide analysis  Critical Care

Sonographic evaluation of intracranial hemodynamics and pressure after out-of-hospital cardiac arrest: An exploratory sub-study of the TAME trial  Critical Care and Resuscitation

The Association Between Elevated Myocardial Injury-Related Biomarker (TnI) and Increased Mortality in Patients With Severe Fever With Thrombocytopenia Syndrome  Critical Care Medicine

The new neural pressure support (NPS) mode and the helmet: did we find the dynamic duo?  Journal of Anesthesia, Analgesia and Critical Care

Trajectory pattern of serially measured acute kidney injury biomarkers in critically ill patients: a prospective observational study  Annals of Intensive Care

Treatment of positive catheter tip culture without bloodstream infections in critically ill patients. A case-cohort study from the OUTCOMEREA network  Intensive Care Medicine

Troponin I as a Predictor of Transcranial Doppler Sonography Defined Vasospasm in Intensive Care Unit Patients After Spontaneous Subarachnoid Hemorrhage  Journal of Intensive Care Medicine

Metadata

Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash