Critical Care Evidence Updates – June 21
Randomised Controlled Trials
The REMAP-CAP Investigators. Effectiveness of Tocilizumab, Sarilumab, and Anakinra for critically ill patients with COVID-19 The REMAP-CAP COVID-19 Immune Modulation Therapy Domain Randomized Clinical Trial. MedRxiv 2021.06.18.21259133
The REMAP-CAP Investigators. Convalescent Plasma in Critically ill Patients with Covid-19 MedRxiv 2021.06.11.21258760
Horby. Casirivimab and imdevimab in patients admitted to hospital with covid-19 (RECOVERY): a randomised, controlled, open-label, platform trial MedRxiv 2021.06.15.21258542v1
RECOVERY Collaborative Group. Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial MedRxiv 2021.06.08.21258132
In case you missed it..
NICE
RapidAI for analysing CT/MRI brain scans in people with suspected acute stroke Medtech innovation briefing (MIB262)
SYNE-COV for predicting COVID-19 outcomes Medtech innovation briefing (MIB264)
Shared decision making NG197
Budesonide orodispersible tablet for inducing remission of eosinophilic oesophagitis TA708
Other Guidance/Reports
Statement on family and relatives visiting during the COVID-19 pandemic Intensive Care Society
Respiratory Support Units: Guidance on development and implementation Intensive Care Society and British Thoracic Society
Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19: updated 03/06/2021 (PDF) Infectious Diseases Society of America
Cochrane
No new relevant reviews published
Systematic Reviews & Meta-analyses
Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19. A Meta-analysis. JAMA. Published online July 6, 2021. doi:10.1001/jama.2021.11330
A living systematic review of the psychological problems in people suffering from COVID-19 Journal of Affective Disorders
Association of Vitamin D Deficiency with COVID-19 Infection Severity: Systematic Review and Meta-analysis Clinical Endocrinology
Biomarkers in delirium: A systematic review Journal of Psychosomatic Research
Effect of earplugs and eye masks on the sleep quality of intensive care unit patients: A systematic review and meta-analysis Journal of Advanced Nursing
Effectiveness of interventions to prevent pressure injury in adults admitted to intensive care settings: A systematic review and meta-analysis of randomised controlled trials Australian Critical Care
Exploring family members’ and health care professionals’ perceptions on ICU diaries: a systematic review and qualitative data synthesis Intensive Care Medicine
Lactated Ringer’s vs normal saline for acute pancreatitis: An updated systematic review and meta-analysis Pancreatology
Monitoring nociception and awareness during palliative sedation: A systematic review Palliative Medicine
Moving from bytes to bedside: a systematic review on the use of artificial intelligence in the intensive care unit Intensive Care Medicine
Risk factors for hypertensive crisis in adult patients: a systematic review Joanna Briggs Institute
Safety of using enteral nutrition formulations containing dietary fiber in hospitalized critical care patients: A systematic review and meta-analysis. Journal of Parenteral and Enteral Nutrition
Sarcopenia as a predictor of mortality among the critically ill in an intensive care unit: a systematic review and meta-analysis BMC Geriatrics
Sex differences in illness severity and mortality among adult intensive care patients: A systematic review and meta-analysis Journal of Critical Care
Sofosbuvir with daclatasvir and the outcomes of patients with COVID-19: a systematic review and meta-analysis with GRADE assessment Postgraduate Medical Journal
Systematic review and meta-analysis of interventions for operating room to intensive care unit handoffs BMJ Quality & Safety
Systematic review of studies investigating ventilator associated pneumonia diagnostics in intensive care BMC Pulmonary Medicine
The effect of high flow nasal oxygen therapy in intensive care units: A systematic review and meta-analysis Expert Review of Respiratory Medicine
The effect of indirect calorimetry guided isocaloric nutrition on mortality in critically ill patients-a systematic review and meta-analysis European Journal of Clinical Nutrition
The effects of intensive care unit-initiated transitional care interventions on elements of post-intensive care syndrome: A systematic review and meta-analysis Australian Critical Care
Venous thromboembolism in COVID-19 compared to non-COVID-19 cohorts: A systematic review with meta-analysis Vascular Pharmacology
Cochrane Clinical Answers
Primary Research
Analysis of mental health symptoms and insomnia levels of intensive care nurses during the COVID-19 pandemic with a structural equation mode Journal of Clinical Nursing
Association between ankle brachial index and development of postoperative intensive care unit delirium in patients with peripheral arterial disease Scientific Reports
Combined antibiotic stewardship and infection control measures to contain the spread of linezolid-resistant Staphylococcus epidermidis in an intensive care unit Antimicrobial Resistance & Infection Control
Comparison of cutaneous facial temperature using infrared thermography to standard temperature measurement in the critical care setting Journal of Clinical Monitoring and Computing
Definition and incidence of hypotension in intensive care unit patients, an international survey of the European Society of Intensive Care Medicine Journal of Critical Care
Handoffs and transitions in critical care—understanding scalability: study protocol for a multicenter stepped wedge type 2 hybrid effectiveness-implementation trial Implementation Science
Insight into the use of tympanic temperature during target temperature management in emergency and critical care: a scoping review Journal of Intensive Care
Measuring family-centred care practices in adult intensive care units: The EMPATHIC-F questionnaire Nursing in Critical Care
Moral distress and ethical climate in intensive care medicine during COVID-19: a nationwide study BMC Medical Ethics
Performance of D-dimer for predicting sepsis mortality in the intensive care unit Biochemical Medicine
Presepsin values and prognostic nutritional index predict mortality in intensive care unit patients with sepsis: a pilot study BMC Research Notes
Psychological distress during the acceleration phase of the COVID-19 pandemic: a survey of doctors practising in emergency medicine, anaesthesia and intensive care medicine in the UK and Ireland Emergency Medicine Journal
Risk Factors of Patient-Related Safety Events during Active Mobilization for Intubated Patients in Intensive Care Units-A Multi-Center Retrospective Observational Study Journal of Clinical Medicine
Risk prediction using the National Early Warning Score and the Worthing Physiological Scoring System in patients who were transported to the Intensive Care Unit from the Emergency Department: A cohort study Intensive and Critical Care Nursing
The experiences of critical care nurses caring for patients with COVID-19 during the 2020 pandemic: A qualitative study Applied Nursing Research
The significance of hope as experienced by the next of kin to critically ill patients in the intensive care unit Scandinavian Journal of Caring Sciences
Usefulness of β-lactam and Macrolide Combination Therapy for Treating Community-acquired Pneumonia Patients Hospitalized in the Intensive Care Unit: Propensity Score Analysis of a Prospective Cohort Study Journal of Infection and Chemotherapy
What’s new in intensive care: environmental sustainability Intensive Care Medicine
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date: July 2021
Picture by: Ehimetalor Akhere Unuabona on Unsplash
