Critical Care Evidence Updates – June 21

Randomised Controlled Trials

The REMAP-CAP Investigators. Effectiveness of Tocilizumab, Sarilumab, and Anakinra for critically ill patients with COVID-19 The REMAP-CAP COVID-19 Immune Modulation Therapy Domain Randomized Clinical Trial. MedRxiv 2021.06.18.21259133

The REMAP-CAP Investigators. Convalescent Plasma in Critically ill Patients with Covid-19 MedRxiv 2021.06.11.21258760

Horby. Casirivimab and imdevimab in patients admitted to hospital with covid-19 (RECOVERY): a randomised, controlled, open-label, platform trial MedRxiv 2021.06.15.21258542v1

RECOVERY Collaborative Group. Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial MedRxiv 2021.06.08.21258132

In case you missed it..


RapidAI for analysing CT/MRI brain scans in people with suspected acute stroke Medtech innovation briefing (MIB262)

SYNE-COV for predicting COVID-19 outcomes Medtech innovation briefing (MIB264)

Shared decision making NG197

Budesonide orodispersible tablet for inducing remission of eosinophilic oesophagitis TA708

Other Guidance/Reports

Statement on family and relatives visiting during the COVID-19 pandemic Intensive Care Society

Respiratory Support Units: Guidance on development and implementation Intensive Care Society and British Thoracic Society

Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19: updated 03/06/2021 (PDF) Infectious Diseases Society of America


No new relevant reviews published

Systematic Reviews & Meta-analyses

Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19. A Meta-analysis. JAMA. Published online July 6, 2021. doi:10.1001/jama.2021.11330

A living systematic review of the psychological problems in people suffering from COVID-19 Journal of Affective Disorders

Association of Vitamin D Deficiency with COVID-19 Infection Severity: Systematic Review and Meta-analysis Clinical Endocrinology

Biomarkers in delirium: A systematic review Journal of Psychosomatic Research

Effect of earplugs and eye masks on the sleep quality of intensive care unit patients: A systematic review and meta-analysis Journal of Advanced Nursing

Effectiveness of interventions to prevent pressure injury in adults admitted to intensive care settings: A systematic review and meta-analysis of randomised controlled trials Australian Critical Care

Exploring family members’ and health care professionals’ perceptions on ICU diaries: a systematic review and qualitative data synthesis Intensive Care Medicine

Lactated Ringer’s vs normal saline for acute pancreatitis: An updated systematic review and meta-analysis Pancreatology

Monitoring nociception and awareness during palliative sedation: A systematic review Palliative Medicine

Moving from bytes to bedside: a systematic review on the use of artificial intelligence in the intensive care unit Intensive Care Medicine

Risk factors for hypertensive crisis in adult patients: a systematic review Joanna Briggs Institute

Safety of using enteral nutrition formulations containing dietary fiber in hospitalized critical care patients: A systematic review and meta-analysis. Journal of Parenteral and Enteral Nutrition

Sarcopenia as a predictor of mortality among the critically ill in an intensive care unit: a systematic review and meta-analysis BMC Geriatrics

Sex differences in illness severity and mortality among adult intensive care patients: A systematic review and meta-analysis Journal of Critical Care

Sofosbuvir with daclatasvir and the outcomes of patients with COVID-19: a systematic review and meta-analysis with GRADE assessment Postgraduate Medical Journal

Systematic review and meta-analysis of interventions for operating room to intensive care unit handoffs BMJ Quality & Safety

Systematic review of studies investigating ventilator associated pneumonia diagnostics in intensive care BMC Pulmonary Medicine

The effect of high flow nasal oxygen therapy in intensive care units: A systematic review and meta-analysis Expert Review of Respiratory Medicine

The effect of indirect calorimetry guided isocaloric nutrition on mortality in critically ill patients-a systematic review and meta-analysis European Journal of Clinical Nutrition

The effects of intensive care unit-initiated transitional care interventions on elements of post-intensive care syndrome: A systematic review and meta-analysis Australian Critical Care

Venous thromboembolism in COVID-19 compared to non-COVID-19 cohorts: A systematic review with meta-analysis Vascular Pharmacology

Cochrane Clinical Answers

How do reactive air surfaces compare with alternating pressure air surfaces for preventing pressure ulcers?

Primary Research

Analysis of mental health symptoms and insomnia levels of intensive care nurses during the COVID-19 pandemic with a structural equation mode Journal of Clinical Nursing

Association between ankle brachial index and development of postoperative intensive care unit delirium in patients with peripheral arterial disease Scientific Reports

Combined antibiotic stewardship and infection control measures to contain the spread of linezolid-resistant Staphylococcus epidermidis in an intensive care unit Antimicrobial Resistance & Infection Control

Comparison of cutaneous facial temperature using infrared thermography to standard temperature measurement in the critical care setting Journal of Clinical Monitoring and Computing

Definition and incidence of hypotension in intensive care unit patients, an international survey of the European Society of Intensive Care Medicine Journal of Critical Care

Handoffs and transitions in critical care—understanding scalability: study protocol for a multicenter stepped wedge type 2 hybrid effectiveness-implementation trial Implementation Science

Insight into the use of tympanic temperature during target temperature management in emergency and critical care: a scoping review Journal of Intensive Care

Measuring family-centred care practices in adult intensive care units: The EMPATHIC-F questionnaire Nursing in Critical Care

Moral distress and ethical climate in intensive care medicine during COVID-19: a nationwide study BMC Medical Ethics

Performance of D-dimer for predicting sepsis mortality in the intensive care unit Biochemical Medicine

Practice, Outcomes and Complications of Emergent Endotracheal Intubation By Critical Care Practitioners During the COVID-19 Pandemic CHEST

Presepsin values and prognostic nutritional index predict mortality in intensive care unit patients with sepsis: a pilot study BMC Research Notes

Psychological distress during the acceleration phase of the COVID-19 pandemic: a survey of doctors practising in emergency medicine, anaesthesia and intensive care medicine in the UK and Ireland Emergency Medicine Journal

Risk Factors of Patient-Related Safety Events during Active Mobilization for Intubated Patients in Intensive Care Units-A Multi-Center Retrospective Observational Study Journal of Clinical Medicine

Risk prediction using the National Early Warning Score and the Worthing Physiological Scoring System in patients who were transported to the Intensive Care Unit from the Emergency Department: A cohort study Intensive and Critical Care Nursing

The experiences of critical care nurses caring for patients with COVID-19 during the 2020 pandemic: A qualitative study Applied Nursing Research

The significance of hope as experienced by the next of kin to critically ill patients in the intensive care unit Scandinavian Journal of Caring Sciences

Usefulness of β-lactam and Macrolide Combination Therapy for Treating Community-acquired Pneumonia Patients Hospitalized in the Intensive Care Unit: Propensity Score Analysis of a Prospective Cohort Study Journal of Infection and Chemotherapy

What’s new in intensive care: environmental sustainability Intensive Care Medicine


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date: July 2021

Picture by: Ehimetalor Akhere Unuabona on Unsplash

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