Critical Care Evidence Updates – March 2022

Randomised Controlled Trials

Accuracy evaluation of mainstream and sidestream end-tidal carbon dioxide monitoring during noninvasive ventilation: a randomized crossover trial (MASCAT-NIV trial) Journal of Intensive Care

Comparison of Effect of Non-invasive Ventilation Delivered by Helmet vs Face Mask in Patients with COVID-19 Infection: A Randomized Control Study Indian Journal of Critical Care Medicine

Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19 – A Randomized Clinical Trial JAMA

Efficacy of a heel offloading boot in reducing heel pressure injuries in patients in Australian intensive care units: A single-blinded randomised controlled trial Intensive and Critical Care Nursing

Efficacy of Losartan in Hospitalized Patients With COVID-19–Induced Lung Injury – A Randomized Clinical Trial JAMA Network Open

Erythropoietin in Acute Kidney Injury (EAKI): a pragmatic randomized clinical trial BMC Nephrology

Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial Critical Care

High-flow nasal oxygen alone or alternating with non-invasive ventilation in critically ill immunocompromised patients with acute respiratory failure: a randomised controlled trial The Lancet Respiratory Medicine

LIBERATE: a study protocol for midodrine for the early liberation from vasopressor support in the intensive care unit (LIBERATE): protocol for a randomized controlled trial Trials

Personalization of renal replacement therapy initiation: a secondary analysis of the AKIKI and IDEAL-ICU trials Critical Care

Randomized controlled trial: neostigmine for intra-abdominal hypertension in acute pancreatitis Critical Care


Mental wellbeing at work NG212

SecurePort IV tissue adhesive for use with percutaneous catheters MIB288

COVID-19 rapid guideline: managing COVID-19 NG191

UroShield for preventing catheter-associated urinary tract infections MTG69

Other Guidance/Reports

Implementing advance care plans in the peri-operative period, including plans for cardiopulmonary resuscitation: Association of Anaesthetists clinical practice guideline Association of Anaesthetists


Anticoagulants for people hospitalised with COVID‐19

Inhaled corticosteroids for the treatment of COVID‐19

Primary Research

A prospective observational cohort study to identify inflammatory biomarkers for the diagnosis and prognosis of patients with sepsis Journal of Intensive Care

Accuracy of heparin-binding protein for the diagnosis of nosocomial meningitis and ventriculitis Critical Care

Association Between Physician Turnover and Survival Outcome After In-Hospital Cardiopulmonary Resuscitation: A Nationwide Cohort Study in South Korea Resuscitation

Brain death: a clinical overview Journal of Intensive Care

Clinical impact of ventilator-associated pneumonia in patients with the acute respiratory distress syndrome: a retrospective cohort study Annals of Intensive Care

Comparison between two solute equations and bioimpedance for estimation of body fluid volumes Intensive Care Medicine Experimental

Early prone positioning in acute respiratory distress syndrome related to COVID-19: a propensity score analysis from the multicentric cohort COVID-ICU network—the ProneCOVID study Critical Care

Effects of different positive end-expiratory pressure titration strategies during prone positioning in patients with acute respiratory distress syndrome: a prospective interventional study Critical Care

Effects of regional citrate anticoagulation on thrombin generation, fibrinolysis and platelet function in critically ill patients receiving continuous renal replacement therapy for acute kidney injury: a prospective study Annals of Intensive Care

Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies Intensive and Critical Care Nursing

High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality New England Journal of Medicine

HVAD to HeartMate 3 left ventricular assist device exchange: Best practices recommendations European Journal of Cardio-Thoracic Surgery

Intensive care unit capacity and mortality in older adults: a three nations retrospective observational cohort study Annals of Intensive Care

Intracranial hemorrhage in COVID-19 patients during extracorporeal membrane oxygenation for acute respiratory failure: a nationwide register study report Critical Care

Ischemic injury of the upper gastrointestinal tract after out-of-hospital cardiac arrest: a prospective, multicenter study Critical Care

Long-term outcomes of dexamethasone 12 mg versus 6 mg in patients with COVID-19 and severe hypoxaemia Intensive Care Medicine

Management of intoxicated patients – a descriptive outcome analysis of 4,267 ICU patients BMC Emergency Medicine

Masseter muscle pressure injury: first report of a prone position complication in patients with COVID-19 Intensive and Critical Care Nursing

Nasal pressure swings as the measure of inspiratory effort in spontaneously breathing patients with de novo acute respiratory failure Critical Care

Natural language processing diagnosed behavioral disturbance vs confusion assessment method for the intensive care unit: prevalence, patient characteristics, overlap, and association with treatment and outcome Intensive Care Medicine

Outcomes After Direct Discharge Home From Critical Care Units: A Population-Based Cohort Analysis Critical Care Medicine

Pain management of nalbuphine and sufentanil in patients admitted intensive care unit of different ages BMC Emergency Medicine

Patient Harm and Institutional Avoidability of Out-of-Hours Discharge From Intensive Care: An Analysis Using Mixed Methods Critical Care Medicine

Prevalence and prognosis of respiratory pendelluft phenomenon in mechanically ventilated ICU patients with acute respiratory failure: a retrospective cohort study Annals of Intensive Care

Prone positioning during veno-venous or veno-arterial extracorporeal membrane oxygenation: feasibility and complications after cardiothoracic surgery Critical Care

Quality indicators of palliative care for cardiovascular intensive care Journal of Intensive Care

Recombinant human interleukin-7 reverses T cell exhaustion ex vivo in critically ill COVID-19 patients Annals of Intensive Care

Result of one-year, prospective follow-up of intensive care unit survivors after SARS-CoV-2 pneumonia Annals of Intensive Care

SSEP N20 and P25 amplitudes predict poor and good neurologic outcomes after cardiac arrest Annals of Intensive Care

Survival benefit of extracorporeal membrane oxygenation in severe COVID-19: a multi-centre-matched cohort study Intensive Care Medicine

The association of modifiable mechanical ventilation settings, blood gas changes and survival on extracorporeal membrane oxygenation for cardiac arrest Resuscitation

The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19 Annals of Intensive Care

The pathogens of secondary infection in septic patients share a similar genotype to those that predominate in the gut Critical Care

Ultraprotective versus apneic ventilation in acute respiratory distress syndrome patients with extracorporeal membrane oxygenation: a physiological study Journal of Intensive Care


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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