Critical Care Evidence Updates – March 2023

Randomised Controlled Trials

A multicentre randomised controlled trial of the McGrath Mac videolaryngoscope versus conventional laryngoscopy  Anaesthesia

Association of early mobility with the incidence of deep-vein thrombosis and mortality among critically ill patients: a post hoc analysis of PREVENT trial  Critical Care

Blood volume in patients likely to be preload responsive: a post hoc analysis of a randomized controlled trial  Intensive Care Medicine Experimental

Customized Citrate Anticoagulation versus No Anticoagulant in Continuous Venovenous Hemofiltration in Critically Ill Patients with Acute Kidney Injury: A Prospective Randomized Controlled Trial  Blood Purification

Early adjunctive methylene blue in patients with septic shock: a randomized controlled trial  Critical Care

Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials  Critical Care

Effects of 12 mg vs. 6 mg dexamethasone on thromboembolism and bleeding in patients with critical COVID-19 – a post hoc analysis of the randomized, blinded COVID STEROID 2 trial  Annals of Intensive Care

Effects of Standard-Dose Prophylactic, High-Dose Prophylactic, and Therapeutic Anticoagulation in Patients With Hypoxemic COVID-19 Pneumonia – The ANTICOVID Randomized Clinical Trial  JAMA Internal Medicine

Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion – The PROCOAG Randomized Clinical Trial  JAMA

Haloperidol vs. placebo for the treatment of delirium in ICU patients: a pre-planned, secondary Bayesian analysis of the AID–ICU trial  Intensive Care Medicine

High-flow nasal oxygen versus conventional oxygen therapy in patients with COVID-19 pneumonia and mild hypoxaemia: a randomised controlled trial  Thorax

Hydrocortisone in Severe Community-Acquired Pneumonia  NEJM

Impact on the ability of healthcare professionals to correctly identify patient-ventilator asynchronies of the simultaneous visualization of estimated muscle pressure curves on the ventilator display: a randomized study (Pmus study)  Critical Care

Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial  Annals of Intensive Care

Intravenous ravulizumab in mechanically ventilated patients hospitalised with severe COVID-19: a phase 3, multicentre, open-label, randomised controlled trial  The Lancet Respiratory Medicine

Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3)  The Lancet Respiratory Medicine

Neurological and respiratory effects of lung protective ventilation in acute brain injury patients without lung injury: brain vent, a single centre randomized interventional study  Critical Care

Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia  NEJM


Acute kidney injury QS76

COVID-19 rapid guideline: managing COVID-19 NG191

Other Guidance/Reports

BTS clinical statement on aspiration pneumonia  Thorax

Emergency Point-of-Care Ultrasound Stewardship – A Joint Position Paper by EuSEM and EFSUMB and Endorsed by IFEM and WFUMB  European Journal of Ultrasound

Guidelines for Neuroprognostication in Adults with Guillain–Barré Syndrome  Neurocritical Care

Immunocompromised Host Pneumonia: Definitions and Diagnostic Criteria: An Official American Thoracic Society Workshop Report  Annals of the American Thoracic Society

Respiratory Management of Patients With Neuromuscular Weakness  Chest

The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition  Critical Care


Therapeutics for treating mpox in humans

Ultrasound and shockwave therapy for acute fractures in adults

Primary Research

Adjunctive Hydrocortisone Improves Hemodynamics in Critically Ill Patients with Septic Shock: An Observational Study Using Transpulmonary Thermodilution  Journal of Intensive Care Medicine

Altered intestinal microbiome and metabolome correspond to the clinical outcome of sepsis  Critical Care

An evaluation of the impact of the implementation of the Tele-ICU: a retrospective observational study  Journal of Intensive Care

Anaemia in the first week may be associated with long-term mortality among critically ill patients: propensity score-based analyses  BMC Emergency Medicine

Angiotensin 1–7 in an experimental septic shock model  Critical Care

Association of Sublingual Microcirculation Parameters and Capillary Refill Time in the Early Phase of ICU Admission  Critical Care Medicine

Cerebro-spinal fluid glucose and lactate concentrations changes in response to therapies in patIents with primary brain injury: the START-TRIP study  Critical Care

Changes in upper airways microbiota in ventilator-associated pneumonia  Intensive Care Medicine Experimental

Clinical significance of human metapneumovirus detection in critically ill adults with lower respiratory tract infections  Annals of Intensive Care

Critically ill severe hypothyroidism: a retrospective multicenter cohort study  Annals of Intensive Care

Efficacy of carbapenem vs non carbapenem β-lactam therapy as empiric antimicrobial therapy in patients with extended-spectrum β-lactamase-producing Enterobacterales urinary septic shock: a propensity-weighted multicenter cohort study  Annals of Intensive Care

Focused liquid ultrasonography in dropsy protocol for quantitative assessment of subcutaneous edema  Critical Care

Hyperoxemia after reperfusion in cardiac arrest patients: a potential dose–response association with 30-day survival  Critical Care

Impact of a strategy based on unique blood culture sampling on contamination rate and detection of bloodstream infections in critically ill patients  Annals of Intensive Care

Implementation of Lung-Protective Ventilation in Patients With Acute Respiratory Failure  Critical Care Medicine

Improvements in Accuracy and Confidence in Rhythm Identification After Cardiac Surgery Using the AtriAmp Signals  Journal of Intensive Care Medicine

Insulin signaling in skeletal muscle during inflammation and/or immobilisation  Intensive Care Medicine Experimental

Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients?  Journal of the Intensive Care Society

Left-ventricular unloading in extracorporeal cardiopulmonary resuscitation due to acute myocardial infarction – A multicenter study  Resuscitation

Limitation of life-sustaining therapies in critically ill patients with COVID-19: a descriptive epidemiological investigation from the COVID-ICU study  Critical Care

Limiting Dynamic Driving Pressure in Patients Requiring Mechanical Ventilation  Critical Care Medicine

Long-Term Prognosis Following Early Rehabilitation in the ICU: A Retrospective Cohort Study  Critical Care Medicine

Long-term outcomes after severe acute kidney injury in critically ill patients: the SALTO study  Annals of Intensive Care

Multimodal Prediction of Favorable Outcome After Cardiac Arrest: A Cohort Study  Critical Care Medicine

Novel serum biomarkers for predicting neurological outcomes in postcardiac arrest patients treated with targeted temperature management  Critical Care

Obesity is Unlikely to be an Impediment to First-Pass Success During the Intubation of Critically Ill Patients  Journal of Intensive Care Medicine

Onset timing and duration of augmented renal clearance in a mixed intensive care unit  Journal of Intensive Care

Patient-Centred Outcomes Following Tracheostomy in Critical Care  Journal of Intensive Care Medicine

Plasma bioactive adrenomedullin on intensive care unit admission is associated with acute respiratory distress syndrome: an observational study  Intensive Care Medicine Experimental

Positive end-expiratory pressure induced changes in airway driving pressure in mechanically ventilated COVID-19 Acute Respiratory Distress Syndrome patients  Critical Care

Postoperative complications and disposition for vascular surgery  Anaesthesia and Intensive Care

Reversible skin microvascular hyporeactivity in patients with immune-mediated thrombocytopenic thrombotic purpura  Critical Care

Sepsis-related coagulopathy treatment based on the disseminated intravascular coagulation diagnostic criteria: a post-hoc analysis of a prospective multicenter observational study  Journal of Intensive Care

Target attainment and population pharmacokinetics of flucloxacillin in critically ill patients: a multicenter study  Critical Care

The Role of Cell Cycle Arrest Biomarkers for Predicting Acute Kidney Injury in Critically Ill COVID-19 Patients: A Multicenter, Observational Study  Critical Care Medicine


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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