Critical Care Evidence Updates – October 2021



Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management : guidance (NG206)

Other Guidance/Reports

Care of the critically ill: quality statement Welsh Government

Consensus-Based Guidelines for the Recognition, Diagnosis, and Management of Hemophagocytic Lymphohistiocytosis in Critically Ill Children and Adults Critical Care Medicine

Multi-professional team-working. The experience and lessons from COVID-19 (PDF) Academy of Medical Royal Colleges


Antibiotics for the treatment of COVID‐19

Anticoagulants for acute ischaemic stroke

Colchicine for the treatment of COVID‐19

Interventions to enable communication for adult patients requiring an artificial airway with or without mechanical ventilator support

Local versus general anaesthesia for carotid endarterectomy

Systematic Reviews from Other Sources

Characteristics and therapy of enteroviral encephalitis: case report and systematic literature review. International Journal of Infectious Diseases

DTB select: Outcomes in patients requiring intensive care for CAR T-cell toxicity Drugs and Therapeutics Bulletin

Efficacy and safety of dexmedetomidine in sepsis patients requiring mechanical ventilation: a systematic review and meta-analysis. Journal of Clinical Pharmacy and Therapeutics

Efficacy and safety of IL-6 inhibitors in patients with COVID-19 pneumonia: a systematic review and meta-analysis of multicentre, randomized trials Annals of Intensive Care

Factors predicting non-ventilated hospital-acquired pneumonia: Systematic review and Meta-analysis. The Journal of Hospital Infection

Hemoperfusion and blood purification strategies in patients with COVID-19: A systematic review. Artificial Organs

Lactate Ringer’s Versus Normal Saline in the Management of Acute Pancreatitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Digestive Diseases and Sciences

Oral health care for the critically ill: a narrative review Critical Care

Predictive power of extubation failure diagnosed by cough strength: a systematic review and meta-analysis Critical Care

Prognostic Factors Associated With Development of Venous Thromboembolism in Critically Ill Patients—A Systematic Review and Meta-Analysis Critical Care Medicine

Prognostic properties of hypoalbuminemia in COVID-19 patients: A systematic review and diagnostic meta-analysis. Clinical Nutrition ESPEN

Quality of life in elderly ICU survivors before the COVID-19 pandemic: a systematic review and meta-analysis of cohort studies. BMJ Open

Racial Disparities in ICU Outcomes: A Systematic Review Critical Care Medicine

Separation from mechanical ventilation and survival after spinal cord injury: a systematic review and meta-analysis Annals of Intensive Care

Systematic review of clinicians’ knowledge, attitudes, and beliefs about nutrition in intensive care. Nutrition in Clinical Practice

The effect of the head-up position on cardiopulmonary resuscitation: a systematic review and meta-analysis Critical Care

Tocilizumab administration for the treatment of hospitalized patients with COVID-19: A systematic review and meta-analysis. Respirology

Tranexamic Acid in Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis Critical Care Medicine

Primary Research

Association between intensive care unit admission of a patient and mental disorders in the spouse: a retrospective matched-pair cohort study Journal of Intensive Care

Association Between Vasopressin Rebranding and Utilization in Patients With Septic Shock Critical Care Medicine

Baricitinib plus Standard of Care for Hospitalised Adults with COVID-19 on Invasive Mechanical Ventilation or Extracorporeal Membrane Oxygenation: Results of a Randomised, Placebo-Controlled Trial MedRxiv preprints

Brain–lung interactions and mechanical ventilation in patients with isolated brain injury Critical Care

Bronchus-blocked ultrasound-guided percutaneous transthoracic needle biopsy (BUS-PTNB) for intubated patients with severe lung diseases Critical Care

Cerebral autoregulation in anoxic brain injury patients treated with targeted temperature management Journal of Intensive Care

Chlorhexidine Gluconate Bathing Program to Reduce Health Care–Associated Infections in Both Critically Ill and Non–Critically Ill Patients Critical Care Nurse

Clinical significance of lactate clearance in patients with cardiogenic shock: results from the RESCUE registry Journal of Intensive Care

Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial The Lancet Respiratory Medicine

Comparison of hydrogel pad and water-circulating blanket cooling methods for targeted temperature management: A propensity score-matched analysis from a prospective multicentre registry Resuscitation Journal

Comparison of prognostic factors between bacteraemic and non-bacteraemic critically ill immunocompetent patients in community-acquired severe pneumococcal pneumonia: a STREPTOGENE sub-study Annals of Intensive Care

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk New England Journal of Medicine

Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab New England Journal of Medicine

Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia – The COVID STEROID 2 Randomized Trial JAMA

Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19. A Randomized Clinical Trial JAMA

Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest – The CAPITAL CHILL Randomized Clinical Trial JAMA

Effect of oral chlorhexidine de-adoption and implementation of an oral care bundle on mortality for mechanically ventilated patients in the intensive care unit (CHORAL): a multi-center stepped wedge cluster-randomized controlled trial Intensive Care Medicine

Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial BMJ

Effects of dexamethasone on immune dysfunction and ventilator-associated pneumonia in COVID-19 acute respiratory distress syndrome: an observational study Journal of Intensive Care

Effects of high flow nasal cannula on the coordination between swallowing and breathing in postextubation patients, a randomized crossover study Critical Care

Efficacy and Safety of Sarilumab in patients with COVID19 Pneumonia: A Randomized, Phase III Clinical Trial (SARTRE Study) Infectious Diseases and Therapy

Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19 The HEP-COVID Randomized Clinical Trial JAMA Internal Medicine

Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial The Lancet Respiratory Medicine

Evaluation of zinc sulfate as an adjunctive therapy in COVID-19 critically ill patients: a two center propensity-score matched study Critical Care

Evolving outcomes of extracorporeal membrane oxygenation support for severe COVID-19 ARDS in Sorbonne hospitals, Paris Critical Care

Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature Critical Care

Handgrip strength to predict extubation outcome: a prospective multicenter trial Annals of Intensive Care

Hastening Death in Canadian ICUs: End-of-Life Care in the Era of Medical Assistance in Dying Critical Care Medicine

Healthcare professional views on barriers to implementation of evidence-based practice in prevention of ventilator-associated events: A qualitative descriptive study Intensive and Critical Care Medicine

Helmet continuous positive airway pressure vs. high flow nasal cannula oxygen in acute cardiogenic pulmonary oedema: a randomized controlled trial European Heart Journal – Acute Cardiovascular Care

High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial Intensive Care Medicine

Hyperdynamic Left Ventricular Ejection Fraction in ICU Patients With Sepsis Critical Care Medicine

Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis New England Journal of Medicine

Impact of tight glucose control on circulating 3-hydroxybutyrate in critically ill patients Critical Care

Impact on antimicrobial consumption of procalcitonin-guided antibiotic therapy for pneumonia/pneumonitis associated with aspiration in comatose mechanically ventilated patients: a multicenter, randomized controlled study Annals of Intensive Care

Intraosseous versus intravenous resuscitation during in-hospital cardiac arrest Resuscitation Journal

Long-term survival of mechanically ventilated patients with severe COVID-19: an observational cohort study Annals of Intensive Care

Multivariate analysis of factors associated with first-pass success in blind placement of a post-pyloric feeding tube: a retrospective study Journal of Intensive Care

Muscle strength and functional outcome after prone positioning in COVID-19 ICU survivors Intensive and Critical Care Medicine

Narrow-spectrum antibiotics for community-acquired pneumonia in Dutch adults (CAP-PACT): a cross-sectional, stepped-wedge, cluster-randomised, non-inferiority, antimicrobial stewardship intervention trial The Lancet Infectious Diseases

Paradox of trimethylamine-N-oxide, the impact of malnutrition on microbiota-derived metabolites and septic patients Journal of Intensive Care

Practices and intravascular catheter infection during on- and off-hours in critically ill patients Annals of Intensive Care

Preexisting Clinical Frailty Is Associated With Worse Clinical Outcomes in Patients With Sepsis Critical Care Medicine

Pressure Support versus Spontaneous Ventilation during Anesthetic Emergence—Effect on Postoperative Atelectasis: A Randomized Controlled Trial Anesthesiology

Prognostic and Predictive Biomarkers in Patients With Coronavirus Disease 2019 Treated With Tocilizumab in a Randomized Controlled Trial Critical Care Medicine

Pulse oximetry waveform: A non-invasive physiological predictor for the return of spontaneous circulation in cardiac arrest patients —- A multicenter, prospective observational study Resuscitation Journal

Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) trial: A phase 1 trial EClinical Medicine

Short And Long-Term Complications Due To Standard And Extended Prone Position Cycles In Covid-19 Patients Intensive and Critical Care Nursing

Simulation Versus Interactive Mobile Learning for Teaching Extracorporeal Membrane Oxygenation to Clinicians: A Randomized Trial Critical Care Medicine

Sodium chloride or Plasmalyte-148 evaluation in severe diabetic ketoacidosis (SCOPE-DKA): a cluster, crossover, randomized, controlled trial Intensive Care Medicine

The effect of opioids on gastrointestinal function in the ICU Critical Care

Timing of antibiotic therapy in the ICU Critical Care

Vasopressor Initiation Within 1 Hour of Fluid Loading Is Associated With Increased Mortality in Septic Shock Patients: Analysis of National Registry Data Critical Care Medicine


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date: 18th November 2021
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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