Critical Care Evidence Updates – October 2023
Randomised Controlled Trials
Adjunctive Dexamethasone for Tuberculous Meningitis in HIV-Positive Adults NEJM
Antimicrobial Multidrug Resistance: Clinical Implications for Infection Management in Critically Ill Patients Microorganisms
Catheter Ablation in End-Stage Heart Failure with Atrial Fibrillation NEJM
Ceftobiprole for Treatment of Complicated Staphylococcus aureus Bacteremia NEJM
Convalescent Plasma for Covid-19–Induced ARDS in Mechanically Ventilated Patients NEJM
Effects of an online information tool on post-traumatic stress disorder in relatives of intensive care unit patients: a multicenter double-blind, randomized, placebo-controlled trial (ICU-Families-Study) Intensive Care Medicine
Effects of CPAP and FiO2 on respiratory effort and lung stress in early COVID-19 pneumonia: a randomized, crossover study Annals of Intensive Care
Effect of Glutamine Administration After Cardiac Surgery on Kidney Damage in Patients at High Risk for Acute Kidney Injury: A Randomized Controlled Trial Anesthesia & Analgesia
Efficacy and Safety of Reparixin in Patients with Severe COVID-19 Pneumonia: A Phase 3, Randomized, Double-Blind Placebo-Controlled Study Infectious Diseases and Therapy
GlideScope versus C-MAC D-blade videolaryngoscope for double-lumen tube intubation in patients with anticipated difficult airways: A multi-center, prospective, randomized, controlled trial Journal of Clinical Anaesthesia
Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia NEJM
Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial Intensive Care Medicine
Landiolol and Organ Failure in Patients With Septic Shock – The STRESS-L Randomized Clinical Trial JAMA
Magnesium sulphate in patients with thrombotic thrombocytopenic purpura (MAGMAT): a randomised, double-blind, superiority trial Intensive Care Medicine
Mega-dose sodium ascorbate: a pilot, single-dose, physiological effect, double-blind, randomized, controlled trial Critical Care
Physiological effects of high-flow nasal cannula oxygen therapy after extubation: a randomized crossover study Annals of Intensive Care
Remote Ischemic Conditioning for Acute Stroke – The RESIST Randomized Clinical Trial JAMA
Sigh Ventilation in Patients With Trauma – The SiVent Randomized Clinical Trial JAMA
Simvastatin in Critically Ill Patients with Covid-19 NEJM
Timing of Complete Revascularization with Multivessel PCI for Myocardial Infarction NEJM
NICE
Pneumonia in adults: diagnosis and management CG191
Other Guidance/Reports
Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association – Circulation
Definition of factor Xa inhibitor–related, life-threatening gastrointestinal bleeding and guidance on when to use reversal therapy: A Delphi panel – Journal of the American College of Emergency Physicians Open
European Academy of Neurology/Peripheral Nerve Society Guideline on diagnosis and treatment of Guillain–Barré syndrome – European Journal of Neurology
Red Blood Cell Transfusion – 2023 AABB International Guidelines – JAMA
Society of Critical Care Medicine and the Infectious Diseases Society of America Guidelines for Evaluating New Fever in Adult Patients in the ICU – Critical Care Medicine
The role of beta-blocker drugs in critically ill patients: a SIAARTI expert consensus statement – Journal of Anesthesia, Analgesia and Critical Care
Cochrane
Cerebrolysin for acute ischaemic stroke
Erector spinae plane block for postoperative pain
Immediate versus delayed versus no antibiotics for respiratory infections
Primary Research
Age and associated outcomes among patients receiving venoarterial extracorporeal membrane oxygenation–analysis of the Extracorporeal Life Support Organization registry Intensive Care Medicine
Airway Pressure Release Ventilation in COVID-19-Associated Acute Respiratory Distress Syndrome—A Multicenter Propensity Score–Matched Analysis Journal of Intensive Care Medicine
Assessing neutrophil-derived ROS production at the bedside: a potential prognostic tool in severe COVID-19 cases Intensive Care Medicine Experimental
Association Between Nurse Copatient Illness Severity and Mortality in the ICU Critical Care Medicine
Association of language concordance and restraint use in adults receiving mechanical ventilation Intensive Care Medicine
Association of pronounced elevation of NET formation and nucleosome biomarkers with mortality in patients with septic shock Annals of Intensive Care
Clinical Warburg effect in lymphoma patients admitted to intensive care unit Annals of Intensive Care
Clinician views on actionable processes of care for prolonged stay intensive care patients and families: A descriptive qualitative study Intensive and Critical Care Nursing
Comparison of communication interfaces for mechanically ventilated patients in intensive care Intensive and Critical Care Nursing
Comparison of whole blood cytokine immunoassays for rapid, functional immune phenotyping in critically ill patients with sepsis Intensive Care Medicine Experimental
Correlation analysis between lung ultrasound scores and pulmonary arterial systolic pressure in patients with acute heart failure admitted to the emergency intensive care unit Journal of Intensive Medicine
Correlation of Sedation Depth During Critical Care Transport and Hospitalization Journal of Intensive Care Medicine
Creating the ICU of the future: patient-centred design to optimise recovery Critical Care
Delirium During Critical Illness and Subsequent Change of Treatment in Patients With Cancer: A Mediation Analysis Critical Care Medicine
Diaphragm excursions as proxy for tidal volume during spontaneous breathing in invasively ventilated ICU patients Intensive Care Medicine Experimental
Dying to be better: Outlining the growing benefits of palliative care training in intensive care medicine Journal of the Intensive Care Society
Echocardiography Does not Reduce Mortality in Sepsis: A Re-Evaluation Using the Medical Information Mart for Intensive Care IV Dataset Critical Care Medicine
Elevated circulating PCSK9 level is associated with 28-day mortality in patients with sepsis: a prospective cohort study BMC Emergency Medicine
Facilitators and barriers to evidence-based practice in central venous access device insertion and management in an intensive care unit: A qualitative study Intensive and Critical Care Nursing
First and final farewells, disrupted family connections and loss: A collective case study exploring the impact of COVID-19 visitor restrictions in critical care Intensive and Critical Care Nursing
Human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis Critical Care
Impact of a cumulative positive fluid balance during the first three ICU days in patients with sepsis: a propensity score-matched cohort study Annals of Intensive Care
Impact of Standardized Multidisciplinary Critical Care Training on Confidence with Critical Illness and Attitudes Towards Interprofessional Education and Multidisciplinary Care Journal of Intensive Care Medicine
Impact of Using Blood Warmer During Continuous Kidney Replacement Therapy in Patients With Acute Kidney Injury Journal of Intensive Care Medicine
Implementation of a Pressure Injury Prevention Protocol for Intensive Care Unit Patients Undergoing Prone Positioning Critical Care Nurse
Improved 30-Day Survival Estimation in ICU Patients: A Comparative Analysis of Different Approaches With Real-World Data Critical Care Medicine
Incidence of asymptomatic catheter-related thrombosis in intensive care unit patients: a prospective cohort study Annals of Intensive Care
Insulin Use Is Associated With Improved Outcomes in Critically Ill Patients With Acute Pancreatitis: A Retrospective Matched Cohort Study Journal of Intensive Care Medicine
Limiting life-sustaining treatment for very old ICU patients: cultural challenges and diverse practices Annals of Intensive Care
Long-term prognostic significance of gasping in out-of-hospital cardiac arrest patients undergoing extracorporeal cardiopulmonary resuscitation: a post hoc analysis of a multi-center prospective cohort study Journal of Intensive Care
Low levels of small HDL particles predict but do not influence risk of sepsis Critical Care
Lung abscess following ventilator-associated pneumonia during COVID-19: a retrospective multicenter cohort study Critical Care
Mortality, incidence, and microbiological documentation of ventilated acquired pneumonia (VAP) in critically ill patients with COVID-19 or influenza Annals of Intensive Care
Nomogram model on estimating the risk of pressure injuries for hospitalized patients in the intensive care unit Intensive and Critical Care Nursing
Oxygen Debt as Predictor of Mortality and Multiple Organ Dysfunction Syndrome in Severe COVID-19 Patients: A Retrospective Study Journal of Intensive Care Medicine
Outcome of comatose patients following cardiac arrest: When mRS completes CPC Resuscitation
Polymyxin B-immobilised fibre column treatment for acute exacerbation of idiopathic pulmonary fibrosis patients with mechanical ventilation: a nationwide observational study Journal of Intensive Care
Prediction of mechanical ventilation outcome by early abdominal-visceral-blood-flow-and-function score in critically ill patients after cardiopulmonary bypass in the ICU: A prospective observational study Journal of Intensive Medicine
Prognosis of critically ill immunocompromised patients with virus-detected acute respiratory failure Annals of Intensive Care
Prognostic value of time-varying dead space estimates in mechanically ventilated patients with acute respiratory distress syndrome Journal of Intensive Medicine
Prospective comparison of prognostic scores for prediction of outcome after out-of-hospital cardiac arrest: results of the AfterROSC1 multicentric study Annals of Intensive Care
Protein-S-100 Beta, a marker of blood–brain barrier dysfunction, is increased in patients with decompensated cirrhosis admitted to the intensive care unit Journal of Intensive Medicine
Safety and Outcome of High-Flow Nasal Oxygen Therapy Outside ICU Setting in Hypoxemic Patients With COVID-19 Critical Care Medicine
Self-reported symptoms experienced by intensive care unit patients: a prospective observational multicenter study Intensive Care Medicine
Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia in Critically Ill Patients: A Cluster Analysis According to Baseline Characteristics, Biological Features, and Chest CT Scan on Admission Critical Care Medicine
Sex Differences in Vital Organ Support Provided to ICU Patients Critical Care Medicine
The diverse invitations to participate in early rehabilitation – A qualitative study of nurse-patient interactions in the intensive care unit Intensive and Critical Care Nursing
The effect of audiobooks on sleep quality and vital signs in intensive care patients Intensive and Critical Care Nursing
The impact of religion on changes in end-of-life practices in European intensive care units: a comparative analysis over 16 years Intensive Care Medicine
The intensive care unit diary as a valuable care tool: A qualitative study of patients’ experiences Intensive and Critical Care Nursing
The role of beta-blocker drugs in critically ill patients: a SIAARTI expert consensus statement Journal of Anesthesia, Analgesia and Critical Care
Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU) Intensive Care Medicine
Validity of the total SOFA score in patients ≥ 80 years old acutely admitted to intensive care units: a post-hoc analysis of the VIP2 prospective, international cohort study Annals of Intensive Care
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
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