Critical Care Evidence Updates – July 2021
Randomised Controlled Trials
Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxia: an international, randomized, blinded trial. MedRxiv 2021;epublished July 24th
Use of a High-Protein Enteral Nutrition Formula to Increase Protein Delivery to Critically Ill Patients: A Randomized, Blinded, Parallel-Group, Feasibility Trial. JPEN J Parenter Enteral Nutr 2021;45(4):699-709
Induced hypernatremia in patients with moderate-to-severe ARDS: a randomized controlled study. ICMx 2021;9:33
In case you missed it..
Treatment of Multisystem Inflammatory Syndrome in Children. N Engl J Med 2021; 385:11-22 DOI: 10.1056/NEJMoa2102968
NICE
Clostridioides difficile infection: antimicrobial prescribing : guidance (NG199)
Acumen IQ sensor for predicting hypotension risk – medtech innovation briefing (MIB266)
Other Guidance/Reports
Clinical guidance for managing COVID-19: Information for RCN members. Updated 06 July 2021 Royal College of Nursing
Catheter Care (PDF) Royal College of Nursing
Better Together: Collaborative working between emergency medicine and critical care: A framework for improved collaborative working between Emergency Medicine (EM) and Intensive Care Medicine (ICM) (PDF) Royal College of Emergency Medicine
Best Practice Standards for the delivery of NHS infection services in the uk Royal College of Pathologists
Physician-assisted dying survey British Medical Association
Continuous Positive Airway Pressure (CPAP) and Bi-level PAP: Clinical risk stratification tool British Thoracic Society
Cochrane
Ivermectin for preventing and treating COVID‐19
Systematic Reviews & Meta-analyses
The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group. Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19A Meta-analysis. JAMA 2021;epublished July 6th
Transmission of Severe Acute Respiratory Syndrome Coronavirus 1 and Severe Acute Respiratory Syndrome Coronavirus 2 During Aerosol-Generating Procedures in Critical Care: A Systematic Review and Meta-Analysis of Observational Studies. Crit Care Med 2021;49(7):1159-1168
Effect of dexmedetomidine on delirium during sedation in adult patients in intensive care units: A systematic review and meta-analysis. J Clin Anesth 2021;69:110157
Accuracy and precision of continuous non-invasive arterial pressure monitoring in critical care: A systematic review and meta-analysis. Intensive & Critical Care Nursing
Factors contributing to poor sleep in critically ill patients: A systematic review and meta-synthesis of qualitative studies. Intensive & Critical Care Nursing
The relationship between sensory stimuli and the physical environment in complex healthcare settings: A systematic literature review. Intensive & Critical Care Nursing
Outcomes sensitive to critical care nurse staffing levels: A systematic review. Intensive & Critical Care Nursing
Experiences and needs of families with a relative admitted to an adult intensive care unit: a systematic review of qualitative studies Joanna Briggs Institute
The negative impact of obesity on the occurrence and prognosis of the 2019 novel coronavirus (COVID-19) disease: a systematic review and meta-analysis. Eating and Weight Disorders
Mental disorders and risk of COVID-19-related mortality, hospitalisation, and intensive care unit admission: a systematic review and meta-analysis. The Lancet Psychiatry
Cochrane Clinical Answers
Primary Research
Transpulmonary thermodilution in patients treated with veno-venous extracorporeal membrane oxygenation Annals of Intensive Care
Mental health outcomes of ICU and non-ICU healthcare workers during the COVID-19 outbreak: a cross-sectional study Annals of Intensive Care
Prevalence and prognostic value of various types of right ventricular dysfunction in mechanically ventilated septic patients Annals of Intensive Care
Noninvasive ventilation vs. high-flow nasal cannula oxygen for preoxygenation before intubation in patients with obesity: a post hoc analysis of a randomized controlled trial Annals of Intensive Care
Outcomes of ICU patients with and without perceptions of excessive care: a comparison between cancer and non-cancer patients Annals of Intensive Care
Plasma glutamine status at intensive care unit admission: an independent risk factor for mortality in critical illness Critical Care
Static compliance and driving pressure are associated with ICU mortality in intubated COVID-19 ARDS Critical Care
Ischemic and Hemorrhagic Stroke Among Critically Ill Patients With Coronavirus Disease 2019: An International Multicenter Coronavirus Disease 2019 Critical Care Consortium Study Critical Care Medicine
Palliative and End-of-Life Care: Prioritizing Compassion Within the ICU and Beyond Critical Care Medicine
Prediction of Postictal Delirium Following Status Epilepticus in the ICU: First Insights of an Observational Cohort Study Critical Care Medicine
A Locally Optimized Data-Driven Tool to Predict Sepsis-Associated Vasopressor Use in the ICU Critical Care Medicine
Role and knowledge of critical care nurses in the assessment and management of hypophosphataemia and refeeding syndrome. A descriptive exploratory study Intensive and Critical Care Nursing
Early detection of intensive care needs and mortality risk by use of five early warning scores in patients with traumatic injuries: An observational study Intensive and Critical Care Nursing
Conditions and strategies to meet the challenges imposed by the COVID-19-related visiting restrictions in the ICU: a Scandinavian cross-sectional study Intensive and Critical Care Nursing
Healthcare personnel’s working conditions in relation to risk behaviours for organism transmission: A mixed-methods study Journal of Clinical Nursing
Practical view of the topical treatment of peripheral venous catheter-related phlebitis: A scoping review Journal of Clinical Nursing
Beyond the physical risk: Psychosocial impact and coping in healthcare professionals during the COVID-19 pandemic Journal of Clinical Nursing
Professional quality of life and caring behaviours among clinical nurses during the COVID-19 pandemic Journal of Clinical Nursing
Evaluating the impact on hospital acquired pressure injury/ulcer incidence in a United Kingdom NHS Acute Trust from use of sub-epidermal scanning technology Journal of Clinical Nursing
Adiponectin decrease was correlated with rising SOFA score and increased 28 days mortality: Beware of potential confounding factors! Journal of Critical Care
Comparison of three cisatracurium dosing strategies in acute respiratory distress syndrome: A focus on drug utilization and improvement in oxygenation Journal of Critical Care
Endothelium-associated biomarkers mid-regional proadrenomedullin and C-terminal proendothelin-1 have good ability to predict 28-day mortality in critically ill patients with SARS-CoV-2 pneumonia: A prospective cohort study Journal of Critical Care
Intensive Care Unit Volume of Sepsis Patients Does Not Affect Mortality: Results of a Nationwide Retrospective Analysis Journal of Intensive Care Medicine
Practices and Patterns of Hourly Neurochecks: Analysis of 8,936 Patients With Neurological Injury Journal of Intensive Care Medicine
Preoperative Vitamin D Deficiency Is Associated With Postoperative Delirium in Critically Ill Patients Journal of Intensive Care Medicine
Relationship Between Body Mass Index and Survival Among Critically Ill Patients With Cirrhosis Journal of Intensive Care Medicine
The Impact of Corticosteroids on Secondary Infection and Mortality in Critically Ill COVID-19 Patients Journal of Intensive Care Medicine
The Safety and Efficacy of Desmopressin in Patients With Intracranial Hemorrhage and a History of Alcohol Use Journal of Intensive Care Medicine
Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia New England Journal of Medicine
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date: 2nd August 2021
Picture by: Ehimetalor Akhere Unuabona on Unsplash
