A compendium of critical appraisals in Intensive Care Medicine research and related specialties
A collection of TBL summaries relevant to Intensive Care Medicine
Treatment of Multisystem Inflammatory Syndrome in Children McArdle. NEJM 2021; 385: 35-45.DOI: 10.1056/NEJMoa2102968 Clinical Question In children with multisystem inflammatory syndrome, what affect do different treatments have on the composite of inotropic support or mechanical ventilation by day 2 or death, and disease severity by day 2? Background Multisystem inflammatory syndrome in children (MIS-C) is a new, rare but serious […]
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In adult patients with moderate to severe traumatic brain injury, does a continuous infusion of 20% saline, compared with standard care along, improve neurological outcomes at six months?
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In patients who are unconscious following out-of-hospital cardiac arrest, does targeted hypothermia compared with targeted normothermia, impact all-cause mortality?
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In critically ill adults, does the use of an intubating stylet compared to tracheal tube alone, increase first-attempt successful intubation?
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In mechanically ventilated adults with sepsis, does the use of dexmedetomidine, compared with propofol, for continuous sedation improve the number of days alive without delirium or coma?
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In adult patients undergoing rapid sequence intubation for emergency surgery, does pre-oxygenation with high-flow nasal oxygen, compared with standard face-mask oxygen, reduce the incidence of oxygen desaturation?
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In adults presenting with subarachnoid haemorrhage (SAH), does ultra early short term treatment with tranexamic acid improve clinical outcome at 6 months?
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In patients with moderate-severe ARDS, does dexamethasone in addition to routine care, compared with routine care alone increase ventilator free days up to day 28?
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In adult trauma patients with major haemorrhage and hypofibrinogenaemia does the use fibrinogen concentrate (FC) compared to cryoprecipitate (cryo) result in a shorter time to administration?
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Conservative oxygen therapy for mechanically ventilated adults with suspected hypoxic ischaemic encephalopathy Young P. 2020; 46(12):2411-2422. Clinical Question In mechanically ventilated adults patients with suspected hypoxic ischaemic encephalopathy does conservative oxygen therapy when compared with usual oxygen therapy decrease the risk of dying or surviving with an unfavourable neurological outcome at 180 days? Background Oxygen is often used liberally in […]
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