OPTALYSE PE
In patients with intermediate risk PE, do low doses of tPA and short durations of ultrasound facilitated catheter directed thrombolysis, result in a reduction in RV:LV diameter at 48 hours?
Continue reading »Category: Summaries
A category to collect all the summaries, so that they can be used in menus and widgets. Please don’t expand this – “Specialties” and “Special Topics” have been created as a custom category sets for the clinical topics.
ROSE
In patients with moderate to severe ARDS, does a strategy of early neuromuscular blockade with heavy sedation, as opposed to usual care with lighter sedation targets, result in a lower 90 day mortality?
Continue reading »REDUCE Haloperidol
In critically ill adults, does haloperidol 1 mg or haloperidol 2 mg given three times a day compared to placebo reduce mortality?
Continue reading »SCARLET
In adult patients with sepsis-associated coagulopathy does the administration of human recombinant thrombomodulin (rhsTM) compared to placebo reduce 28 day mortality?
Continue reading »EPVent2
Does titrating positive end-expiratory pressure (PEEP) with the use of an esophageal balloon to estimate pleural pressure improve outcomes compared with an empirical high PEEP –FiO2 strategy in patients with moderate – severe acute respiratory distress syndrome (ARDS)
Continue reading »EXTEND
In patients with acute ischaemic stroke, with salvageable brain tissue, does alteplase compared with placebo, administered between 4.5 – 9 hours post stroke onset, improve functional outcome at 90 days?
Continue reading »SPICE III
In ventilated, critically ill patients, does the use of dexmedetomidine as the primary sedative agent compared with usual sedative agents effect 90 day mortality?
Continue reading »PreVent
In adult ICU patients undergoing tracheal intubation, does bag mask ventilation (BMV) between induction and laryngoscopy reduce the risk of hypoxaemia?
Continue reading »MAPAS
Early Manipulation of Arterial Blood Pressure in Acute Ischemic Stroke(MAPAS):Results of a Randomized Controlled Trial Luiz Antonio Nasi. Neurocritical Care 2019; doi: https://doi.org/10.1007/s12028-018-0642-5 Clinical Question In adult patients presenting within 12 hours of an acute ischaemic stroke (AIS), which of three targeted and pre-specified systolic blood pressure (SBP) ranges results in an improved functional outcome at 90 days? Background Significant […]
Continue reading »SHoC-ED 3
In patients presenting to the Emergency Department (ED) in cardiac arrest, does a standardised point-of-care ultrasound protocol, compared with usual care, affect the length of resuscitation, frequency of interventions, and clinical outcomes?
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