Category: Uncategorized

BIHCA – Sodium Bicarbonate for In-Hospital Cardiac Arrest

7 September 2026 Aniket Nadkarni Uncategorized Leave a comment

Sodium Bicarbonate for In-Hospital Cardiac Arrest Granfeldt A. JAMA 2026; doi:10.1001/jama.2026.10628 Clinical Question In adults with in-hospital cardiac arrest, does sodium bicarbonate administration during arrest, improve return of spontaneous circulation, compared with placebo? Background Inpatient cardiac arrest is relatively common and outcomes are poor despite the rapid provision of hospital-based advanced life support. Severe acidemia during cardiac arrest may impair […]

Sodium Bicarbonate for Metabolic Acidosis in the Intensive Care Unit (SODa-BIC) trial

29 June 2026 Aniket Nadkarni Intensive Care Medicine, Uncategorized Leave a comment

Sodium Bicarbonate for Metabolic Acidosis in the Intensive Care Unit (SODa-BIC) trial The SODa-BIC Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group. NEJM 2026; doi: 10.1056/NEJMoa2600526 Clinical Question In critically ill adults with metabolic acidosis (pH < 7.30) receiving vasopressors, does sodium bicarbonate decrease the risk of major adverse kidney events within 30 days compared […]

PREPARE II

13 January 2023 Omar Jundi Evidence-based Medicine, Intensive Care Medicine, Uncategorized Leave a comment

Effect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation @DerekRussellMD. JAMA; 328(3):270-279. doi:10.1001/jama.2022.9792 Clinical Question In critically ill adult patients undergoing tracheal intubation and positive pressure ventilation, does intravenous infusion of a 500ml fluid bolus vs no fluid bolus, decrease the incidence of cardiovascular collapse during, or shortly after the procedure? Background Tracheal intubation […]