Critical Care Evidence Updates – May 2022

Randomised Controlled Trials

A comparison between thoracic epidural analgesia and rectus sheath catheter analgesia after open midline major abdominal surgery: randomized clinical trial – BJS Open

A Randomized Double-Blinded Placebo Controlled Trial of Clazakizumab for the Treatment of COVID-19 Pneumonia With Hyperinflammation – Critical Care Medicine

Aggressive intraoperative warming versus routine thermal management during non-cardiac surgery (PROTECT): a multicentre, parallel group, superiority trial – The Lancet

Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial – The Lancet Respiratory Medicine

Clinical and biochemical endpoints and predictors of response to plasma exchange in septic shock: results from a randomized controlled trial – Critical Care

Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial – Intensive Care Medicine

Comparison of tenecteplase with alteplase for the early treatment of ischaemic stroke in the Melbourne Mobile Stroke Unit (TASTE-A): a phase 2, randomised, open-label trial – The Lancet Neurology

Daily Written Care Summaries for Families of Critically Ill Patients: A Randomized Controlled Trial – Critical Care Medicine

Effect of abdominal weight training with and without cough machine assistance on lung function in the patients with prolonged mechanical ventilation: a randomized trial – Critical Care

Effect of Awake Prone Positioning on Endotracheal Intubation in Patients With COVID-19 and Acute Respiratory Failure – A Randomized Clinical Trial – JAMA

Effect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas The RACECAT Randomized Clinical Trial – JAMA

Effect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation – The SETPOINT2 Randomized Clinical Trial – JAMA

Fast multiplex bacterial PCR of bronchoalveolar lavage for antibiotic stewardship in hospitalised patients with pneumonia at risk of Gram-negative bacterial infection (Flagship II): a multicentre, randomised controlled trial – The Lancet Respiratory Medicine

High-flow nasal oxygen versus conventional oxygen therapy in patients with COVID-19 pneumonia and mild hypoxaemia: a randomised controlled trial – Thorax

Impact of prolonged requirement for insulin on 90-day mortality in critically ill patients without previous diabetic treatments: a post hoc analysis of the CONTROLING randomized control trial – Critical Care

Physiological effects of high-intensity versus low-intensity noninvasive positive pressure ventilation in patients with acute exacerbation of chronic obstructive pulmonary disease: a randomised controlled trial – Annals of Intensive Care

Randomized Clinical Study of Temporary Transvenous Phrenic Nerve Stimulation in Difficult-to-Wean Patients – American Journal of Respiratory Critical Care Medicine

Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses – The Lancet

Sequential use of midazolam and dexmedetomidine for long-term sedation may reduce weaning time in selected critically ill, mechanically ventilated patients: a randomized controlled study – Critical Care

Tenecteplase versus alteplase for the management of acute ischaemic stroke in Norway (NOR-TEST 2, part A): a phase 3, randomised, open-label, blinded endpoint, non-inferiority trial – The Lancet Neurology

The Effect of a Liberal Approach to Glucose Control in Critically Ill Patients with Type 2 Diabetes: A multicenter, parallel-group, open-label, randomized clinical trial – American Journal of Respiratory and Critical Care Medicine

TTCOV19: timing of tracheotomy in SARS-CoV-2-infected patients: a multicentre, single-blinded, randomized, controlled trial – Critical Care



Other Guidance/Reports

Clinical Practice Guideline: Early Mobilization and Rehabilitation of Critically Ill Burn Patients – Journal of Burn Care & Research

Guidelines for the choice of intravenous fluids for vascular filling in critically ill patients, 2021 – Anaesthesia Critical Care & Pain Medicine

United Kingdom standards for non-invasive cardiac imaging: recommendations from the Imaging Council of the British Cardiovascular Society – Heart

Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline – Intensive Care Medicine


Magnesium sulfate for acute exacerbations of chronic obstructive pulmonary disease

Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting

Primary Research

A multicentre evaluation exploring the impact of an integrated health and social care intervention for the caregivers of ICU survivors – Critical Care

Acute respiratory distress syndrome after in-hospital cardiac arrest – Resuscitation

Association Between Use of a Flying Intervention Team vs Patient Interhospital Transfer and Time to Endovascular Thrombectomy Among Patients With Acute Ischemic Stroke in Nonurban Germany – JAMA

Association of immediate reinsertion of new catheters with subsequent mortality among patients with suspected catheter infection: a cohort study – Annals of Intensive Care

Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest – Resuscitation

Catheter dressings – Intensive Care Medicine

Clinical impact of preoperative diaphragm dysfunction on early outcomes and ventilation function in lung transplant: a single-center retrospective study – Journal of Intensive Care

Comparison of the predictive ability of clinical frailty scale and hospital frailty risk score to determine long-term survival in critically ill patients: a multicentre retrospective cohort study – Critical Care

Cytomegalovirus blood reactivation in COVID-19 critically ill patients: risk factors and impact on mortality – Intensive Care Medicine

Diagnostic concordance between BioFire® FilmArray® Pneumonia Panel and culture in patients with COVID-19 pneumonia admitted to intensive care units: the experience of the third wave in eight hospitals in Colombia – Critical Care

Does the cytokine adsorber CytoSorb® reduce vancomycin exposure in critically ill patients with sepsis or septic shock? a prospective observational study – Annals of Intensive Care

Early intubation and decreased in-hospital mortality in patients with coronavirus disease 2019 – Critical Care

Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis – Critical Care

Effect of erythromycin on mortality and the host response in critically ill patients with sepsis: a target trial emulation – Critical Care

External validation of 5A score model for predicting in-hospital mortality among the accidental hypothermia patients: JAAM-Hypothermia study 2018–2019 secondary analysis – Annals of Intensive Care

Family perspectives on facilitators and barriers to the set up and conduct of virtual visiting in intensive care during the COVID-19 pandemic: A qualitative interview study – Intensive and Critical Care Nursing

Flow-controlled ventilation in moderate acute respiratory distress syndrome due to COVID-19: an open-label repeated-measures controlled trial – Intensive Care Medicine Experimental

Hospital-onset sepsis and community-onset sepsis in critical care units in Japan: a retrospective cohort study based on a Japanese administrative claims database – Critical Care

Hydrocephalus and the neuro-intensivist: CSF hydrodynamics at the bedside – Intensive Care Medicine Experimental

Impairment of neutrophil functions and homeostasis in COVID-19 patients: association with disease severity – Critical Care

In search of the Holy Grail: identifying the best PEEP in ventilated patients – Intensive Care Medicine

Integrating palliative care into the ICU: a lasting and developing legacy – Intensive Care Medicine

Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome – Critical Care

Lung response to prone positioning in mechanically-ventilated patients with COVID-19 – Critical Care

Management of moderate to severe traumatic brain injury: an update for the intensivist – Intensive Care Medicine

Medical nutrition therapy and clinical outcomes in critically ill adults: a European multinational, prospective observational cohort study (EuroPN) – Critical Care

Monitoring of circulating monocyte HLA-DR expression in a large cohort of intensive care patients: relation with secondary infections – Annals of Intensive Care

Presence of comorbidities alters management and worsens outcome of patients with acute respiratory distress syndrome: insights from the LUNG SAFE study – Annals of Intensive Care

Prone positioning improves ventilation–perfusion matching assessed by electrical impedance tomography in patients with ARDS: a prospective physiological study – Critical Care

Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19 – Critical Care Medicine

Ten tips to optimize vasopressors use in the critically ill patient with hypotension – Intensive Care Medicine

The ability of Oxygen Reserve Index® to detect hyperoxia in critically ill patients – Annals of Intensive Care

Tracheostomy Practices and Outcomes in Patients With COVID-19 Supported by Extracorporeal Membrane Oxygenation: An Analysis of the Extracorporeal Life Support Organization Registry Critical Care Medicine

Usefulness of lung ultrasound for early detection of hospital-acquired pneumonia in cardiac critically ill patients on venoarterial extracorporeal membrane oxygenation – Annals of Intensive Care

Venous return and mean systemic filling pressure: physiology and clinical applications – Critical Care


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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