Tag: Cardiac Surgery

CLIPII – Cryopreserved vs Liquid-Stored Platelets

Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding: The CLIP-II Randomized Noninferiority Clinical Trial Reade. JAMA, 2025. doi: 10.1001/jama.2025.23355 Clinical Question In adult cardiac surgery patients at high risk of bleeding, is the transfusion of cryopreserved platelets, compared with conventional liquid-stored platelets, non-inferior in reducing postoperative bleeding within the first 24 hours after ICU admission? Background Platelet transfusion […]

TIGHT K: Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery

Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery: The TIGHT K Randomized Clinical Trial O’Brien. JAMA 2024; 332:979 – 988. doi:10.1001/jama.2024.17888 Clinical Question In adult patients undergoing coronary artery bypass surgery (CABG) is supplementing potassium when serum concentration is ≤ 3.5 mEq/L non-inferior to supplementation when serum concentration is ≤ 4.5 mEq/L to reduce the frequency of new […]

PROTECTION – Amino Acids for Kidney Protection

7 July 2024 Celia Bradford Intensive Care Medicine, Peri-operative Medicine Leave a comment

In adult patients scheduled for cardiac surgery with cardiopulmonary bypass does infusion of a balanced solution of amino acids, commencing at the time of surgery, compared with balanced crystalloid alone (Ringer’s Lactate) reduce the incidence of acute kidney injury (AKI)?

PALACS

31 December 2021 Celia Bradford Intensive Care Medicine, Peri-operative Medicine Leave a comment

Posterior left pericardiotomy for the prevention of atrial fibrillation after cardiac surgery Mario Gaudino, The Lancet Dec 4 2021; 398: 2075–83 https://doi.org/10.1016/S0140-6736(21)02490-9 Clinical Question In selected patients undergoing cardiac surgery, does posterior left pericardiotomy compared with usual care, reduce the incidence of postoperative atrial fibrillation? Background Atrial fibrillation is common following cardiac surgery with approximately one-third of patients developing […]

Zochios

30 August 2019 Peter Szedlak Intensive Care Medicine, Peri-operative Medicine Leave a comment

In patients at high risk of respiratory complications after cardiac surgery, does the routine application of high-flow nasal oxygen compared to standard oxygen reduce hospital length of stay?

TRICS-III 6 month follow up

5 October 2018 Steve Mathieu Intensive Care Medicine, Peri-operative Medicine Leave a comment

In patients undergoing cardiac surgery, who have a moderate-to-high risk of death, does a restrictive transfusion strategy compared with a liberal strategy impact on a composite outcome of death, myocardial infarction, stroke and acute kidney injury requiring dialysis at 6 months after surgery?

TRICS-III

24 November 2017 Celia Bradford Intensive Care Medicine, Peri-operative Medicine Leave a comment

ATACAS TXA

29 September 2017 George Walker Peri-operative Medicine Leave a comment

In adult patients undergoing elective coronary-artery surgery does tranexamic acid (TXA) compared to a placebo increase the risk of death or thrombotic complications within the first 30 days after surgery?

ATACAS Asp

29 September 2017 George Walker Peri-operative Medicine Leave a comment

In adults undergoing elective coronary artery graft surgery does the administration of aspirin prior to surgery compared to a placebo result in increased mortality or thrombotic complications?

LEVO-CTS

31 March 2017 Celia Bradford Intensive Care Medicine, Peri-operative Medicine 2 comments

In patients with LVEF <35% undergoing cardiac surgery does levosimenden compared with placebo reduce the incidence of a composite outcome of: death at day 30; renal replacement therapy at day 30; perioperative myocardial infarct at day 5; and use of mechanical assist device at day 5

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