COLCOT
In patients post myocardial infarction, does low dose colchicine compared with placebo, reduce ischaemic cardiovascular events?
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CRASH-3
Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH – 3): a randomised, placebo-controlled trial The CRASH-3 trial collaborators. The Lancet, 2019; doi.org/10.1016/S1040-6736(19)32233-0 Clinical Question In patients with traumatic brain injury (TBI), does the administration of tranexamic acid (TXA) under 3 hours from injury, compared with placebo, reduce […]
Continue reading »ICU-ROX
In mechanically ventilated ICU patients does a conservative use of oxygen therapy compared to usual oxygen therapy affect the number of ventilator-free-days?
Continue reading »Vitamin C Sepsis
Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial Fowler AA. JAMA; 2019;322(13):1261-1270 Clinical Question In patients with sepsis and acute respiratory distress syndrome, can intravenous administration of vitamin C, compared to placebo, reduce organ failure scores and biomarkers of inflammation and vascular injury? […]
Continue reading »Subira
In patients weaning from mechanical ventilation, does a spontaneous breathing trial (SBT) with pressure support (PS) for 30 minutes vs a SBT with T-piece for 2 hours differ in the rate of successful liberation from mechanical ventilation (MV)?
Continue reading »HYPERION
In patients with coma following cardiac arrest with a non-shockable rhythm, does moderate hypothermia vs. normothermia, improve neurological outcome?
Continue reading »Garrouste-Orgeas
In intensive care patients, does an ICU diary compared to no ICU diary, reduce post-traumatic stress disorder symptoms at 3 months?
Continue reading »PHARLAP
Does an open lung ventilation strategy which includes maximal recruitment maneuvers (RMs) and positive end-expiratory pressure (PEEP) titration improve outcomes compared to traditional lung-protective ventilation in patients with moderate – severe acute respiratory distress syndrome (ARDS)?
Continue reading »PAUSE
In patients with atrial fibrillation (AF) on direct oral anticoagulant (DOAC) medications, does a standard approach to therapy interruption and resumption in the perioperative period result in an acceptable risk for bleeding and thromboembolic events?
Continue reading »AVERT Shock
In trauma patients with hemorrhagic shock, does the use of low-dose arginine vasopressin compared to placebo reduce the volume of blood products transfused?
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