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In adults with an expected ICU stay of > 72 hours, does the provision of enteral melatonin compared to placebo increase the number of delirium-free assessments within 14 days or before ICU discharge?
Continue reading »A compendium of critical appraisals in Intensive Care Medicine research and related specialties
In adults with an expected ICU stay of > 72 hours, does the provision of enteral melatonin compared to placebo increase the number of delirium-free assessments within 14 days or before ICU discharge?
Continue reading »Early Active Mobilization during Mechanical Ventilation in the ICU @chodgsonANZICRC @TEAMtrialICU. NEJM 2022; 387:1747-58 doi:10.1056/NEJMoa2209083 Clinical Question In mechanically ventilated adult patients does the provision of early mobilisation when compared to standard care increase the number of days alive and out of hospital at 180 days? Background ICU Acquired weakness (ICUAW) is common with one systematic review reporting a median […]
Continue reading »Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation Semler. N Engl J Med 2022; 387:1759-1769. DOI: 10.1056/NEJMoa2208415 Clinical Question In patients receiving invasive mechanical ventilation, does a target oxygen saturation of 90%, 94%, or 98% increase days alive and free of mechanical ventilation at 28 days? Background Despite the ubiquity of oxygen therapy in the critical care setting, the […]
Continue reading »Operative vs Nonoperative Treatment of Acute Unstable Chest Wall Injuries: A Randomised Clinical TrialĀ Dehghan et al. JAMA Surg 2022 doi:10.1001/jamasurg.2022.4299 Background Blunt chest wall trauma has high associated rates of morbidity and mortality RCTs have shown a reduced ICU length of stay in those requiring mechanical ventilation, however this has not been replicated in non-ventilated patients What did they […]
Continue reading »In mechanically ventilated adults, does the addition of selective decontamination of the digestive tract (SDD) compared to standard care reduce all-cause hospital mortality within 90 days?
Continue reading »In patients with refractory VF, does Double Sequential External Defibrillation or Vector-change Defibrillation improve survival to hospital discharge?
Continue reading »In comatose patients following cardiac arrest does a restrictive compared with a liberal oxygenation strategy, reduce death or survival at discharge with a poor neurological outcome?
Continue reading »Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest Kjaergaard et al | New England Journal of Medicine| August 2022 DOI: 10.1056/NEJMoa2208687 Clinical Question In patients with return of spontaneous circulation (ROSC) after cardiac arrest does a higher MAP target (> 77mmHg) compared to a standard targetĀ (>63mmHg) reduce death or survival at discharge with a poor neurological status? Background Manipulation […]
Continue reading »In adults with acute pancreatitis does aggressive fluid resuscitation compared to moderate resuscitation result in a reduction in the development of moderately severe or severe pancreatitis?
Continue reading »In adult patients with sepsis receiving vasopressor therapy, does a high dose of vitamin C in comparison to placebo, reduce the risk of death or persistent organ dysfunction at 28 days?
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