BOX Trial: Blood Pressure

Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest Kjaergaard et al | New England Journal of Medicine| August 2022 DOI: 10.1056/NEJMoa2208687 Clinical Question In patients with return of spontaneous circulation (ROSC) after cardiac arrest does a higher MAP target (> 77mmHg) compared to a standard target  (>63mmHg) reduce death or survival at discharge with a poor neurological status? Background Manipulation […]

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Diuretics Versus Volume Expansion in the Initial Management of Acute Intermediate High‐Risk Pulmonary Embolism Ferrari E. Lung (2022); DOI:10.1007/s00408-022-00530-5 Clinical Question In adult patients with acute pulmonary embolism and right heart strain does a strategy of volume expansion or early diuretic therapy result in a more rapid resolution of troponin levels? Background Acute pulmonary embolism (PE) is a common cause […]

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