Tag: Haematology

FARES II: PCC vs FFP in Cardiac Surgery

23 May 2025 Aniket Nadkarni Intensive Care Medicine, Summaries Leave a comment

Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery The FARES-II Multicenter Randomized Clinical Trial Karkouthi. JAMA 2025; doi:10.1001/jama.2025.3501 Clinical Question In adults undergoing cardiac surgery with cardiopulmonary bypass, is the use of a 4-factor prothrombin complex concentrate (PCC), compared to fresh frozen plasma (FFP), safe and efficacious in treating active or anticipated bleeding? Background Bleeding post […]

TRAIN – Transfusion Strategies in Acute Brain Injured Patients

26 October 2024 andrew.achilleos@nhs.net Intensive Care Medicine, Summaries One comment

Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury @fabio_taccone. JAMA. 2024. PMID: 39382241 Clinical Question In patients with acute brain injury, does a liberal, compared to a restrictive strategy of blood transfusion, improve neurological outcomes at 180 days? Background The TRICC study, published over 20 years go, led to the widespread adoption of restrictive thresholds for blood […]

ANNEXA-I – Andexanet for Factor Xa Inhibitor–Associated ICH

10 July 2024 George Walker Emergency Medicine, Intensive Care Medicine One comment

In patients who have recently taken factor Xa inhibitors with an intracerebral haemorrhage (ICH) did the administration of Andexanet result in better haemostatic efficacy compared to standard care?

Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia

28 July 2023 George Walker Evidence-based Medicine, Intensive Care Medicine Leave a comment

In haematology or ICU patients with platelet counts between 10,000 and 50,000 per mm3, is receiving no prophylactic platelets non inferior compared to the administration of 1u platelets in order to reduce the risk of catheter-related bleeding?

PATCH

19 June 2023 Celia Bradford Emergency Medicine, Intensive Care Medicine Leave a comment

In adult patients with major trauma, who are at risk for trauma-induced coagulopathy does early administration of 1g of tranexamic acid (TXA) followed by an infusion of 1g over 8 hours, compared with placebo, increase survival with a favourable functional outcome at 6 months?

TRAAP2

14 May 2021 George Walker Peri-operative Medicine Leave a comment

In patients undergoing caesarean section (CS) does the administration of tranexamic acid (TXA) when compared to placebo result in a lower incidence of calculated estimated blood loss of red blood cell transfusion by day 2?

ULTRA

23 April 2021 Halah Zareian Emergency Medicine, Intensive Care Medicine, Summaries 2 comments

In adults presenting with subarachnoid haemorrhage (SAH), does ultra early short term treatment with tranexamic acid improve clinical outcome at 6 months?

FEISTY

9 April 2021 George Walker Emergency Medicine, Intensive Care Medicine, Summaries Leave a comment

In adult trauma patients with major haemorrhage and hypofibrinogenaemia does the use fibrinogen concentrate (FC) compared to cryoprecipitate (cryo) result in a shorter time to administration?

CHARLI

12 March 2021 andrew.achilleos@nhs.net Intensive Care Medicine, Summaries Leave a comment

In patients with or at risk of Acute Respiratory Distress Syndrome (ARDS), can nebulised heparin compared to placebo, accelerate recovery of physical function?

REALITY

6 March 2021 Celia Bradford Intensive Care Medicine Leave a comment

In patients with acute myocardial infarction and anaemia is a restrictive, compared with a liberal transfusion strategy, non-inferior with respect to major adverse cardiovascular outcomes at 30 days?

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