Target Protein – Augmented Enteral Protein During Critical Illness

Augmented Enteral Protein During Critical Illness MJ Summers. JAMA 2025; doi: 10.1001/jama.2025.9110 Clinical Question In critically ill patients receiving enteral nutrition does the augmentation of protein delivery compared to standard care result in an increased number of days free of the index hospital and alive at day 90? Background Critical illness weakness is a common complication within the ICU population […]

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TGC-Fast: Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU

Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU Gunst et al. N Engl J Med 2023;389:1180-1190 DOI: 10.1056/NEJMoa2304855 Clinical Question In ICU patients not receiving early parenteral nutrition, does liberal glucose control (initiating insulin when blood glucose level [BGL] >11.9 mmol per liter [>215 mg per deciliter]) or tight glucose control (commencing insulin at BGL 4.4 to 6.1 […]

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Continued enteral nutrition until extubation compared with fasting before extubation

Continued enteral nutrition until extubation compared with fasting before extubation in patients in the intensive care unit: an open-label, cluster-randomised, parallel-group, non-inferiority trial  Landais et al. The Lancet Respiratory Medicine 2023. 11:319-28. doi://10.1016/ S2213-2600(22)00413-1  Clinical Question  In patients ventilated for more than 48h in the Intensive Care Unit, is continued enteral nutrition compared with fasting prior to extubation, non-inferior with […]

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