Tag: Sepsis

Immunosep – Precision Immunotherapy to Improve Sepsis Outcomes

21 January 2026 Patrick McNamara Intensive Care Medicine Leave a comment

Precision Immunotherapy to Improve Sepsis Outcomes Giamarellos-Bourboulis. JAMA 2025. doi:10.001/jama.2025.24175 Clinical Question In patients with sepsis, does immunotherapy (using either anakinra or human interferon gamma) that is tailored to the type of immune dysregulation lead to a reduction in organ dysfunction at day 9? Background Sepsis can involve a dysregulated immune response to an infection (SIDP, sepsis induced immune dysfunction) […]

ANDROMEDA-SHOCK2 – Personalized Hemodynamic Resuscitation

Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock ANDROMEDA SHOCK 2 Investigators @ShockAndromeda2. JAMA 2025. doi:10.1001/jama.2025.20402 Clinical Question In adult patients with early septic shock, does a personalised haemodynamic resuscitation protocol targeting capillary refill time (CRT) normalisation improve outcomes compared to usual care? Background In septic shock, the pathophysiological mechanisms contributing to the development of a shocked […]

ASTER – Acetaminophen in Sepsis

9 January 2025 Generic Contributor Intensive Care Medicine Leave a comment

Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis Ware. JAMA 2024. doi:10.1001/jama.2024.8772 Clinical Question In critically ill adult patients with sepsis does the administration of acetaminophen compared to placebo increase the number of days alive and free of organ support to day 28? Background Acetaminophen is a potent and specific haemoprotein reductant that can […]

BLING III – Continuous vs Intermittent Antibiotics

15 August 2024 Generic Contributor Intensive Care Medicine Leave a comment

In critically ill adult patients with presumed sepsis, does the administration of β-lactam antibiotics via a continuous infusion compared to an intermittent infusion reduce 90-day mortality?

ACORN

10 January 2024 George Walker Emergency Medicine, Intensive Care Medicine Leave a comment

In acutely ill adults (ED / ICU) does the administration of cefipime or piperacillin-tazobactam (pip-taz) result in an increased incidence of AKI or death by day 14?

STRESS-L: Landiolol and Organ Failure in Patients With Septic Shock

29 October 2023 George Walker Intensive Care Medicine, Summaries Leave a comment

Landiolol and Organ Failure in Patients With Septic Shock Whitehouse. JAMA Published online October 25, 2023. doi:10.1001/jama.2023.20134 Clinical Question In patients with tachycardia and septic shock who are treated with high dose norepinephrine does the use of β-blockade for up to 14 days reduce organ failure compared to standard care? Background Many view the use of β-blockade as contentious in […]

CLOVERS

27 January 2023 George Walker Emergency Medicine, Intensive Care Medicine One comment

In patients with sepsis-induced hypotension does a restrictive fluid strategy (with early vasopressor usage) compared to a liberal fluid strategy result in lower mortality before discharge by day 90?

LOVIT Trial

12 August 2022 kirtivashist00@gmail.com Intensive Care Medicine, Summaries One comment

In adult patients with sepsis receiving vasopressor therapy, does a high dose of vitamin C in comparison to placebo, reduce the risk of death or persistent organ dysfunction at 28 days?

CandiSep

12 August 2022 George Walker Intensive Care Medicine, Summaries Leave a comment

In septic adults at high risk for invasive candida infection (ICI) does the use (1,3)-β-D-glucan (BDG) guided antifungal strategy, compared with standard treatment, reduce 28-day mortality compared to standard care?

Classic Trial

18 June 2022 George Walker Emergency Medicine, Intensive Care Medicine One comment

In adult patients in ICU with septic shock, does a restrictive approach to fluid therapy compared to a standard care result in fewer deaths at day 90?

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