Critical Care Evidence Updates – August 2021

Randomised Controlled Trials

Mathew. Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock. N Engl J Med 2021;385:516-525

Desch. Angiography after Out-of-Hospital Cardiac Arrest without ST-Segment Elevation. N Engl J Med 2021 epublished August 29th

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19 – The REMAP-CAP, ACTIV-4a, and ATTACC Investigators. New England Journal of Medicine

A randomized controlled trial to determine whether beta-hydroxy-beta-methylbutyrate and/or eicosapentaenoic acid improves diaphragm and quadriceps strength in critically Ill mechanically ventilated patients Critical Care

An adaptive randomized controlled trial of non-invasive respiratory strategies in acute respiratory failure patients with COVID-19 medRxiv (preprint)

Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial The Lancet Respiratory Medicine

Biotrauma during ultra-low tidal volume ventilation and venoarterial extracorporeal membrane oxygenation in cardiogenic shock: a randomized crossover clinical trial Annals of Intensive Care

Continuous renal replacement therapy in COVID-19—associated AKI: adding heparin to citrate to extend filter life—a retrospective cohort study Critical Care

Ceftolozane/tazobactam versus meropenem in patients with ventilated hospital-acquired bacterial pneumonia: subset analysis of the ASPECT-NP randomized, controlled phase 3 trial Critical Care

Comparing the Effect of Neostigmine and Metoclopramide on Gastric Residual Volume of Mechanically Ventilated Patients in Intensive Care Unit: A Double-Blind Randomized Clinical Trial BioMed Research International

Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients: A Pilot Randomised Controlled Trial Annals of the American Thoracic Society

Helmet Non-Invasive Ventilation for COVID-19 Patients (Helmet-COVID): study protocol for a multicentre randomised controlled trial BMJ Open

Effect of Slower vs Faster Intravenous Fluid Bolus Rates on Mortality in Critically Ill Patients – The BaSICS Randomized Clinical Trial JAMA

Effectiveness of enteral ivabradine for heart rate control in septic shock: A randomised controlled trial Anaesthesia and Intensive Care

Inhaled isoflurane via the anaesthetic conserving device versus propofol for sedation of invasively ventilated patients in intensive care units in Germany and Slovenia: an open-label, phase 3, randomised controlled, non-inferiority trial The Lancet Respiratory Medicine

In case you missed it..

NICE

Patient Status Engine for wireless monitoring of vital signs – medtech innovation briefing (MIB271)

Other Guidance/Reports

Antithrombotic Therapy for VTE Disease: Second Update of the CHEST Guideline and Expert Panel Report – Executive Summary Chest

Caring for hospital patients with COVID-19. Quality of care in England examined by case record review Royal College of Physicians of London

Hard to Swallow? A review of the quality of dysphagia care provided to patients with Parkinson’s disease aged 16 years and over who were admitted to hospital when acutely unwell (PDF) National Confidential Enquiry into Patient Outcome and Death

) The Speech and Language Therapy Pillar : A supplementary resource of the Allied Health Professionals (AHP) Critical Care Professional Development Framework (CCPDF) Intensive Care Society

Cochrane

Interventions for palliative symptom control in COVID‐19 patients

Systemic corticosteroids for the treatment of COVID‐19

Remdesivir for the treatment of COVID‐19

Enteral tube feeding for people with severe dementia

Primary Research

A tutorial on individualized treatment effect prediction from randomized trials with a binary endpoint Statistics in Medicine

A quantitative analysis of extension and distribution of lung injury in COVID-19: a prospective study based on chest computed tomography Critical Care

Adjunctive ketamine for sedation in critically ill mechanically ventilated patients: an active-controlled, pilot, feasibility clinical trial Journal of Intensive Care

Association of intensity of ventilation with 28-day mortality in COVID-19 patients with acute respiratory failure: insights from the PRoVENT-COVID study Critical Care

Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial The Lancet Respiratory Medicine

Awake Prone Positioning Strategy for Nonintubated Hypoxic Patients with COVID-19: A Pilot Trial with Embedded Implementation Evaluation Annals of the American Thoracic Society

Breathing variability—implications for anaesthesiology and intensive care Critical Care

Challenges and opportunities in point-of-care ultrasound: A qualitative exploration of respiratory physiotherapists’ experiences of lung ultrasound training and its adoption in critical care Ultrasound

Circulating dipeptidyl peptidase 3 on intensive care unit admission is a predictor of organ dysfunction and mortality Journal of Intensive Care

Continuous renal replacement therapy in COVID-19—associated AKI: adding heparin to citrate to extend filter life—a retrospective cohort study Critical Care

Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients: A Pilot Randomised Controlled Trial Annals of the American Thoracic Society

Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients Critical Care

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk New England Journal of Medicine

Early high antibody-titre convalescent plasma for hospitalised COVID-19 patients: DAWn-plasma European Respiratory Journal

Effect of awake prone position on diaphragmatic thickening fraction in patients assisted by noninvasive ventilation for hypoxemic acute respiratory failure related to novel coronavirus disease Critical Care

Effect of bundle set interventions on physiologic alarms and alarm fatigue in an intensive care unit: A quality improvement project Intensive and Critical Care Nursing

Effectiveness of continuous endotracheal cuff pressure control for the prevention of ventilator associated respiratory infections: an open-label randomised, controlled trial Clinical Infectious Diseases

Evaluation of pain severity in critically ill patients on mechanical ventilation Intensive and Critical Care Nursing

Healthcare professionals’ experiences during the initial stage of the COVID-19 pandemic in the ICU, a qualitative study Intensive and Critical Care Nursing

Impact of baseline beta-blocker use on inotrope response and clinical outcomes in cardiogenic shock: a subgroup analysis of the DOREMI trial Critical Care

In-hospital COVID-19 outbreak investigation: a practical approach to root cause analysis Intensive and Critical Care Nursing

Inhaled liposomal amphotericin-B as a prophylactic treatment for COVID-19-associated pulmonary aspergillosis/aspergillus tracheobronchitis Critical Care

Initial antimicrobial management of sepsis Critical Care

Long-Term Acute Care Hospital Outcomes of Mechanically Ventilated Patients With Coronavirus Disease 2019 Critical Care Medicine

Monocyte-to-lymphocyte ratio is associated with 28-day mortality in patients with acute respiratory distress syndrome: a retrospective study Journal of Intensive Care

Norepinephrine potentiates the efficacy of volume expansion on mean systemic pressure in septic shock Critical Care

Outbreak of Pseudomonas aeruginosa producing VIM carbapenemase in an intensive care unit and its termination by implementation of waterless patient care Critical Care

Physiotherapy in Patients on the Organ Donation Pathway: A Survey of Current Practice Transplantation Proceedings

Serum renin and major adverse kidney events in critically ill patients: a multicenter prospective study Critical Care

Should We Prolong the Observation Period for Neurological Recovery After Cardiac Arrest? Critical Care Medicine

The application of an oxygen mask, without supplemental oxygen, improved oxygenation in patients with severe COVID-19 already treated with high-flow nasal cannula Critical Care

The Association Between the Decision to Withdraw Life-Sustaining Therapy and Patient Mortality in U.K. ICUs Critical Care Medicine

The core of patient-participation in the Intensive Care Unit: The patient’s views Intensive and Critical Care Nursing

The meaning of caring touch for healthcare professionals in an intensive care unit: A qualitative interview study Intensive and Critical Care Nursing

Triggers for new-onset atrial fibrillation in critically ill patients Intensive and Critical Care Nursing

Metadata

Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date: 4th September 2021
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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