Critical Care Evidence Updates – August 2021
Randomised Controlled Trials
Mathew. Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock. N Engl J Med 2021;385:516-525
Desch. Angiography after Out-of-Hospital Cardiac Arrest without ST-Segment Elevation. N Engl J Med 2021 epublished August 29th
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19 – The REMAP-CAP, ACTIV-4a, and ATTACC Investigators. New England Journal of Medicine
An adaptive randomized controlled trial of non-invasive respiratory strategies in acute respiratory failure patients with COVID-19 medRxiv (preprint)
Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial The Lancet Respiratory Medicine
Biotrauma during ultra-low tidal volume ventilation and venoarterial extracorporeal membrane oxygenation in cardiogenic shock: a randomized crossover clinical trial Annals of Intensive Care
Comparing the Effect of Neostigmine and Metoclopramide on Gastric Residual Volume of Mechanically Ventilated Patients in Intensive Care Unit: A Double-Blind Randomized Clinical Trial BioMed Research International
Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients: A Pilot Randomised Controlled Trial Annals of the American Thoracic Society
Effectiveness of enteral ivabradine for heart rate control in septic shock: A randomised controlled trial Anaesthesia and Intensive Care
Inhaled isoflurane via the anaesthetic conserving device versus propofol for sedation of invasively ventilated patients in intensive care units in Germany and Slovenia: an open-label, phase 3, randomised controlled, non-inferiority trial The Lancet Respiratory Medicine
In case you missed it..
NICE
Patient Status Engine for wireless monitoring of vital signs – medtech innovation briefing (MIB271)
Other Guidance/Reports
Caring for hospital patients with COVID-19. Quality of care in England examined by case record review Royal College of Physicians of London
Hard to Swallow? A review of the quality of dysphagia care provided to patients with Parkinson’s disease aged 16 years and over who were admitted to hospital when acutely unwell (PDF) National Confidential Enquiry into Patient Outcome and Death
) The Speech and Language Therapy Pillar : A supplementary resource of the Allied Health Professionals (AHP) Critical Care Professional Development Framework (CCPDF) Intensive Care Society
Cochrane
Interventions for palliative symptom control in COVID‐19 patients
Systemic corticosteroids for the treatment of COVID‐19
Remdesivir for the treatment of COVID‐19
Enteral tube feeding for people with severe dementia
Primary Research
A tutorial on individualized treatment effect prediction from randomized trials with a binary endpoint Statistics in Medicine
Adjunctive ketamine for sedation in critically ill mechanically ventilated patients: an active-controlled, pilot, feasibility clinical trial Journal of Intensive Care
Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial The Lancet Respiratory Medicine
Awake Prone Positioning Strategy for Nonintubated Hypoxic Patients with COVID-19: A Pilot Trial with Embedded Implementation Evaluation Annals of the American Thoracic Society
Breathing variability—implications for anaesthesiology and intensive care Critical Care
Circulating dipeptidyl peptidase 3 on intensive care unit admission is a predictor of organ dysfunction and mortality Journal of Intensive Care
Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients: A Pilot Randomised Controlled Trial Annals of the American Thoracic Society
Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk New England Journal of Medicine
Early high antibody-titre convalescent plasma for hospitalised COVID-19 patients: DAWn-plasma European Respiratory Journal
Effect of bundle set interventions on physiologic alarms and alarm fatigue in an intensive care unit: A quality improvement project Intensive and Critical Care Nursing
Effectiveness of continuous endotracheal cuff pressure control for the prevention of ventilator associated respiratory infections: an open-label randomised, controlled trial Clinical Infectious Diseases
Evaluation of pain severity in critically ill patients on mechanical ventilation Intensive and Critical Care Nursing
Healthcare professionals’ experiences during the initial stage of the COVID-19 pandemic in the ICU, a qualitative study Intensive and Critical Care Nursing
In-hospital COVID-19 outbreak investigation: a practical approach to root cause analysis Intensive and Critical Care Nursing
Initial antimicrobial management of sepsis Critical Care
Long-Term Acute Care Hospital Outcomes of Mechanically Ventilated Patients With Coronavirus Disease 2019 Critical Care Medicine
Monocyte-to-lymphocyte ratio is associated with 28-day mortality in patients with acute respiratory distress syndrome: a retrospective study Journal of Intensive Care
Norepinephrine potentiates the efficacy of volume expansion on mean systemic pressure in septic shock Critical Care
Physiotherapy in Patients on the Organ Donation Pathway: A Survey of Current Practice Transplantation Proceedings
Serum renin and major adverse kidney events in critically ill patients: a multicenter prospective study Critical Care
Should We Prolong the Observation Period for Neurological Recovery After Cardiac Arrest? Critical Care Medicine
The Association Between the Decision to Withdraw Life-Sustaining Therapy and Patient Mortality in U.K. ICUs Critical Care Medicine
The core of patient-participation in the Intensive Care Unit: The patient’s views Intensive and Critical Care Nursing
The meaning of caring touch for healthcare professionals in an intensive care unit: A qualitative interview study Intensive and Critical Care Nursing
Triggers for new-onset atrial fibrillation in critically ill patients Intensive and Critical Care Nursing
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date: 4th September 2021
Picture by: Ehimetalor Akhere Unuabona on Unsplash