Critical Care Evidence Updates – December 2024

Randomised Controlled Trials

A phase III randomized controlled non-inferiority trial to study the efficacy and safety of imipenem/cilastatin/relebactam (IMI/REL) versus piperacillin/tazobactam (PIP/TAZ) in patients with hospital-acquired bacterial pneumonia (HABP) or ventilator-associated bacterial pneumonia (VABP)  International Journal of Infectious Diseases

Cryospray reduces pain during venous cannulation in elective surgery patients: a randomized placebo-controlled study  BMC Anesthesiology

Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis-Study of Treatment’s Echocardiographic Mechanisms (CLOVERS-STEM)  Critical Care Explorations

Effect of low-dose administration of carperitide for acute heart failure: the LASCAR-AHF trial  European Heart Journal – Acute Cardiovascular Care

Effectiveness of Ventilation via an Endotracheal Tube in Pharynx Versus a Facemask in Patients With Potentially Difficult Airway: A Randomized, Crossover, and Blind Trial  Anesthesia & Analgesia

Effects of postoperative glucocorticoids on mitigation of organ dysfunction in patients with type A aortic dissection: a randomized controlled trial  European Journal of Cardio-Thoracic Surgery

Effects of two different dexamethasone dosing regimens on ventilator-free days and long-term mortality in COVID-19 patients with moderate-to-severe ARDS: the REMED randomized clinical trial  European Journal of Medical Research

Furosemide with adjunctive acetazolamide vs furosemide only in critically ill patients: A pilot two-center randomized controlled trial  Journal of Critical Care

Impact on fluid balance of an optimized restrictive strategy targeting non-resuscitative fluids in intensive care patients with septic shock: a single-blind, multicenter, randomized, controlled, pilot study  Critical Care

Influence of liberal versus conservative oxygen therapies on the hemodynamic parameters of mechanically ventilated patients with sepsis: a randomized clinical trial  BMC Anesthesiology

Mobile App–Facilitated Collaborative Palliative Care Intervention for Critically Ill Older Adults – A Randomized Clinical Trial  JAMA Internal Medicine

Potential causal association between gut microbiota, inflammatory cytokines, and acute pancreatitis: A Mendelian randomization study  Journal of Intensive Medicine

REmoval of cytokines during CArdiac surgery (RECCAS): a randomised controlled trial  Critical Care

Safety and efficacy of intravenous recombinant human prourokinase for acute ischaemic stroke within 4·5 h after stroke onset (PROST-2): a phase 3, open-label, non-inferiority, randomised controlled trial  The Lancet Neurology

Seven versus 14 days of antimicrobial therapy for severe multidrug-resistant Gram-negative bacterial infections in intensive care unit patients (OPTIMISE): a randomised, open-label, non-inferiority clinical trial  Critical Care

The Caregiver Pathway Intervention Can Contribute to Reduced Post-Intensive Care Syndrome Among Family Caregivers of ICU Survivors: A Randomized Controlled Trial  Critical Care Medicine

Vancomycin administration and AUC/MIC in patients with acute kidney injury on hemodialysis (HD): randomized clinical trial  Scientific Reports

 

Other Guidance/Reports

Intracranial multimodal monitoring in neurocritical care (Neurocore-iMMM): an open, decentralized consensus  Critical Care

Key summary of German national guideline for adult patients with nosocomial pneumonia- Update 2024 Funding number at the Federal Joint Committee (G-BA): 01VSF22007  Infection

Large-Core Ischemic Stroke Endovascular Treatment: A Science Advisory From the American Heart Association  Stroke

Multidisciplinary Expert Guidance for the Management of Severe Bleeding on Oral Anticoagulation: An Algorithm for Practicing Clinicians  Thrombosis and Haemostasis

Palliative and End-of-Life Care in Stroke: A Scientific Statement From the American Heart Association  Stroke

Primary Research

A simulated ‘can’t intubate, can’t oxygenate’ manikin crossover study investigating a modified front-of-neck access airway device  Anaesthesia and Intensive Care

Animal-assisted intervention services across UK intensive care units: A national service evaluation  Journal of the Intensive Care Society

Association of continuous renal replacement therapy downtime with fluid balance gap and clinical outcomes: a retrospective cohort analysis utilizing EHR and machine data  Journal of Intensive Care

Comparison of methods to normalize urine output in critically ill patients: a multicenter cohort study  Critical Care

Contribution and evolution of respiratory muscles function in weaning outcome of ventilator-dependent patients  Critical Care

Core outcome set of daily monitoring of gastrointestinal function in adult critically ill patients: a modified Delphi consensus process (COSMOGI)  Critical Care

Dental Hygienist Intervention to Prevent Ventilator-Associated Pneumonia in an Intensive Care Unit  Critical Care Nurse

Dynamic assessment of signal entropy for prognostication and secondary brain insult detection after traumatic brain injury  Critical Care

Early Mobility After Cardiac Surgery: A Quality Improvement Project  Critical Care Nurse

Effect of fluid and driving pressure on cyclical “on–off” flow of pulmonary microcirculation during mechanical ventilation  Intensive Care Medicine Experimental

Examination of Risk Factors Affecting the Development of BSI and Mortality in Critically Ill COVID-19 Patients Hospitalized in Intensive Care Unit (ICU): A Single-Center Retrospective Study  Journal of Intensive Care Medicine

Family concerns in organ donor conversations: a qualitative embedded multiple-case study  Critical Care

Feasibility and safety of ultra-low volume ventilation (≤ 3 ml/kg) combined with extra corporeal carbon dioxide removal (ECCO2R) in acute respiratory failure patients  Critical Care

Ig-M and Ig-A Enriched Ig-G Infusion as Adjuvant Therapy in the Critically ill Patients Experiencing SARS-CoV-2 Severe Infection  Journal of Intensive Care Medicine

Improving Cardiogenic Shock Team Activation Through Nurse Education and Alert Implementation Critical Care Nurse

Influence of underlying condition and performance of sepsis bundle in very old patients with sepsis: a nationwide cohort study  Annals of Intensive Care

Intracranial complications in adult patients with severe pneumococcal meningitis: a retrospective multicenter cohort study  Annals of Intensive Care

Left Ventricular Energetics in Patients Receiving Veno-Arterial Extracorporeal Membrane Oxygenation for Extracorporeal Cardiopulmonary Resuscitation  Resuscitation

Long-term prevalence of PTSD symptom in family members of severe COVID-19 patients: a serial follow-up study extending to 18 months after ICU discharge  Journal of Intensive Care

Longitudinal assessment of immunoglobulin response and disease progression in critically ill patients with community acquired pneumonia  Critical Care

Longitudinal trend in post-discharge estimated glomerular filtration rate in intensive care survivors  Journal of the Intensive Care Society

Lower versus higher blood pressure targets during intensive care of comatose patients resuscitated from out-of-hospital cardiac arrest – A Bayesian analysis of the BOX trial  European Heart Journal – Acute Cardiovascular Care

Management of diabetic keto-acidosis in adult patients admitted to intensive care unit: an ESICM-endorsed international survey  Critical Care

Mechanical Power Is Associated With Mortality in Pressure-Controlled Ventilated Patients: A Dutch, Single-Center Cohort Study  Critical Care Explorations

Modification in ICU design may influence circadian serum cholinesterase activities: a proof-of-concept pilot study  Intensive Care Medicine Experimental

Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality  Critical Care

Nailfold videocapillaroscopy – a novel method for the assessment of hemodynamic incoherence on the ICU  Critical Care

Obesity Is Associated With Increased Mortality in Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation  Critical Care Medicine

Outcomes after critical care admission in people with a learning disability  Journal of the Intensive Care Society

Outcomes for older patients with subarachnoid haemorrhage who require admission to an Australian intensive care unit  Journal of the Intensive Care Society

Pathogenic Burden, Antimicrobial Resistance Pattern and Clinical Outcome of Nosocomial Bloodstream Infections in Intensive Care Unit  Journal of Intensive Care Medicine

Rethinking ARDS classification: oxygenation impairment fails to predict VILI risk  Intensive Care Medicine

Sex-Specific Obesity Paradox in Critically Ill Patients With Severe Acute Kidney Injury: A Retrospective Analysis  Critical Care Medicine

The effects of blood cell salvage on transfusion requirements after decannulation from veno-venous extracorporeal membrane oxygenation: an emulated trial analysis  Critical Care

The legacy of the COVID-19 pandemic on critical care research: A descriptive interview study  Journal of the Intensive Care Society

Ultrasound-Guided Percutaneous Cryoneurolysis for the Treatment of Pain following Traumatic Rib Fracture: A Randomized, Active-Controlled, Participant- and Observer-Masked Study  Anesthesiology

Urinary proteomics identifies distinct immunological profiles of sepsis associated AKI sub-phenotypes  Critical Care

Valproic Acid for Hyperactive Delirium and Agitation in Critically Ill Patients  Journal of Intensive Care Medicine

Metadata

Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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