Critical Care Evidence Updates – December 2024
Randomised Controlled Trials
A phase III randomized controlled non-inferiority trial to study the efficacy and safety of imipenem/cilastatin/relebactam (IMI/REL) versus piperacillin/tazobactam (PIP/TAZ) in patients with hospital-acquired bacterial pneumonia (HABP) or ventilator-associated bacterial pneumonia (VABP) International Journal of Infectious Diseases
Cryospray reduces pain during venous cannulation in elective surgery patients: a randomized placebo-controlled study BMC Anesthesiology
Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis-Study of Treatment’s Echocardiographic Mechanisms (CLOVERS-STEM) Critical Care Explorations
Effect of low-dose administration of carperitide for acute heart failure: the LASCAR-AHF trial European Heart Journal – Acute Cardiovascular Care
Effectiveness of Ventilation via an Endotracheal Tube in Pharynx Versus a Facemask in Patients With Potentially Difficult Airway: A Randomized, Crossover, and Blind Trial Anesthesia & Analgesia
Effects of postoperative glucocorticoids on mitigation of organ dysfunction in patients with type A aortic dissection: a randomized controlled trial European Journal of Cardio-Thoracic Surgery
Effects of two different dexamethasone dosing regimens on ventilator-free days and long-term mortality in COVID-19 patients with moderate-to-severe ARDS: the REMED randomized clinical trial European Journal of Medical Research
Furosemide with adjunctive acetazolamide vs furosemide only in critically ill patients: A pilot two-center randomized controlled trial Journal of Critical Care
Influence of liberal versus conservative oxygen therapies on the hemodynamic parameters of mechanically ventilated patients with sepsis: a randomized clinical trial BMC Anesthesiology
Mobile App–Facilitated Collaborative Palliative Care Intervention for Critically Ill Older Adults – A Randomized Clinical Trial JAMA Internal Medicine
Potential causal association between gut microbiota, inflammatory cytokines, and acute pancreatitis: A Mendelian randomization study Journal of Intensive Medicine
REmoval of cytokines during CArdiac surgery (RECCAS): a randomised controlled trial Critical Care
The Caregiver Pathway Intervention Can Contribute to Reduced Post-Intensive Care Syndrome Among Family Caregivers of ICU Survivors: A Randomized Controlled Trial Critical Care Medicine
Vancomycin administration and AUC/MIC in patients with acute kidney injury on hemodialysis (HD): randomized clinical trial Scientific Reports
Other Guidance/Reports
Intracranial multimodal monitoring in neurocritical care (Neurocore-iMMM): an open, decentralized consensus Critical Care
Multidisciplinary Expert Guidance for the Management of Severe Bleeding on Oral Anticoagulation: An Algorithm for Practicing Clinicians Thrombosis and Haemostasis
Primary Research
A simulated ‘can’t intubate, can’t oxygenate’ manikin crossover study investigating a modified front-of-neck access airway device Anaesthesia and Intensive Care
Animal-assisted intervention services across UK intensive care units: A national service evaluation Journal of the Intensive Care Society
Association of continuous renal replacement therapy downtime with fluid balance gap and clinical outcomes: a retrospective cohort analysis utilizing EHR and machine data Journal of Intensive Care
Comparison of methods to normalize urine output in critically ill patients: a multicenter cohort study Critical Care
Contribution and evolution of respiratory muscles function in weaning outcome of ventilator-dependent patients Critical Care
Dental Hygienist Intervention to Prevent Ventilator-Associated Pneumonia in an Intensive Care Unit Critical Care Nurse
Dynamic assessment of signal entropy for prognostication and secondary brain insult detection after traumatic brain injury Critical Care
Early Mobility After Cardiac Surgery: A Quality Improvement Project Critical Care Nurse
Effect of fluid and driving pressure on cyclical “on–off” flow of pulmonary microcirculation during mechanical ventilation Intensive Care Medicine Experimental
Examination of Risk Factors Affecting the Development of BSI and Mortality in Critically Ill COVID-19 Patients Hospitalized in Intensive Care Unit (ICU): A Single-Center Retrospective Study Journal of Intensive Care Medicine
Family concerns in organ donor conversations: a qualitative embedded multiple-case study Critical Care
Ig-M and Ig-A Enriched Ig-G Infusion as Adjuvant Therapy in the Critically ill Patients Experiencing SARS-CoV-2 Severe Infection Journal of Intensive Care Medicine
Improving Cardiogenic Shock Team Activation Through Nurse Education and Alert Implementation Critical Care Nurse
Influence of underlying condition and performance of sepsis bundle in very old patients with sepsis: a nationwide cohort study Annals of Intensive Care
Intracranial complications in adult patients with severe pneumococcal meningitis: a retrospective multicenter cohort study Annals of Intensive Care
Long-term prevalence of PTSD symptom in family members of severe COVID-19 patients: a serial follow-up study extending to 18 months after ICU discharge Journal of Intensive Care
Longitudinal trend in post-discharge estimated glomerular filtration rate in intensive care survivors Journal of the Intensive Care Society
Lower versus higher blood pressure targets during intensive care of comatose patients resuscitated from out-of-hospital cardiac arrest – A Bayesian analysis of the BOX trial European Heart Journal – Acute Cardiovascular Care
Management of diabetic keto-acidosis in adult patients admitted to intensive care unit: an ESICM-endorsed international survey Critical Care
Mechanical Power Is Associated With Mortality in Pressure-Controlled Ventilated Patients: A Dutch, Single-Center Cohort Study Critical Care Explorations
Modification in ICU design may influence circadian serum cholinesterase activities: a proof-of-concept pilot study Intensive Care Medicine Experimental
Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality Critical Care
Nailfold videocapillaroscopy – a novel method for the assessment of hemodynamic incoherence on the ICU Critical Care
Obesity Is Associated With Increased Mortality in Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation Critical Care Medicine
Outcomes after critical care admission in people with a learning disability Journal of the Intensive Care Society
Outcomes for older patients with subarachnoid haemorrhage who require admission to an Australian intensive care unit Journal of the Intensive Care Society
Pathogenic Burden, Antimicrobial Resistance Pattern and Clinical Outcome of Nosocomial Bloodstream Infections in Intensive Care Unit Journal of Intensive Care Medicine
Rethinking ARDS classification: oxygenation impairment fails to predict VILI risk Intensive Care Medicine
Sex-Specific Obesity Paradox in Critically Ill Patients With Severe Acute Kidney Injury: A Retrospective Analysis Critical Care Medicine
The legacy of the COVID-19 pandemic on critical care research: A descriptive interview study Journal of the Intensive Care Society
Urinary proteomics identifies distinct immunological profiles of sepsis associated AKI sub-phenotypes Critical Care
Valproic Acid for Hyperactive Delirium and Agitation in Critically Ill Patients Journal of Intensive Care Medicine
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash