Critical Care Evidence Updates – February 2022

Randomised Controlled Trials

Actively implementing an evidence-based feeding guideline for critically ill patients (NEED): a multicenter, cluster-randomized, controlled trial – Critical Care

Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial – Critical Care

Cuff Leak Test and Airway Obstruction in Mechanically Ventilated Intensive Care Unit Patients: A Pilot Randomized Controlled Clinical Trial – Annals of the American Thoracic Society

Cytokine adsorption in patients with post-cardiac arrest syndrome after extracorporeal cardiopulmonary resuscitation (CYTER) – A single-centre, open-label, randomised, controlled trial – Resuscitation

Early metabolic support for critically ill trauma patients: A prospective randomized controlled trial – The Journal of Trauma and Acute Care Surgery

Effect of Interleukin-6 Receptor Antagonists in Critically Ill Adult Patients with COVID-19 Pneumonia: two Randomised Controlled Trials of the CORIMUNO-19 Collaborative Group – European Respiratory Journal

Effect of Moderate Hypothermia vs Normothermia on 30-Day Mortality in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation – A Randomized Clinical Trial – JAMA

Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial – Intensive Care Medicine

Efficacy and safety of baricitinib plus standard of care for the treatment of critically ill hospitalised adults with COVID-19 on invasive mechanical ventilation or extracorporeal membrane oxygenation: an exploratory, randomised, placebo-controlled trial – The Lancet Respiratory Medicine

Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities – The I-TECH Randomized Clinical Trial – JAMA Internal Medicine

Lung- and Diaphragm-Protective Ventilation by Titrating Inspiratory Support to Diaphragm Effort: A Randomized Clinical Trial – Critical Care Medicine

Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial – Intensive Care Medicine

Therapeutic Hyperthermia Is Associated With Improved Survival in Afebrile Critically Ill Patients With Sepsis – A Pilot Randomized Trial – Critical Care Medicine

Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial – Critical Care


COVID-19 rapid guideline: managing COVID-19 NG191

EarlyCDT Lung for assessing risk of lung cancer in solid lung nodules – guidance (DG46)

Other Guidance/Reports

Acute-on-Chronic Liver Failure Clinical Guidelines – American College of Gastroenterology

Guidance on Pin Site Care (PDF) – Royal College of Nursing


Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD)

Primary Research

A qualitative exploration of nurse-physician collaboration in intensive care units -Intensive and Critical Care Nursing

Association of Metformin Use During Hospitalization and Mortality in Critically Ill Adults With Type 2 Diabetes Mellitus and Sepsis – Critical Care Medicine

Association of ventilator type with hospital mortality in critically ill patients with SARS-CoV2 infection: a prospective study – Annals of Intensive Care

Bedside post-pyloric tube placement using direct visualisation in mechanically ventilated patients: A single centre case series – Intensive and Critical Care Nursing

Burden of care related to monitoring patient vital signs during intensive care; a descriptive retrospective database study – Intensive and Critical Care Nursing

Cell cycle arrest biomarkers for predicting renal recovery from acute kidney injury: a prospective validation study – Annals of Intensive Care

Detection of cerebral hypoperfusion with a dynamic hyperoxia test using brain oxygenation pressure monitoring – Critical Care

Effects of targeted temperature management at 33 °C vs. 36 °C on comatose patients after cardiac arrest stratified by the severity of encephalopathy – Resuscitation

Extracorporeal membrane oxygenation for COVID-19 and influenza H1N1 associated acute respiratory distress syndrome: a multicenter retrospective cohort study – Critical Care

Factors associated with acute mesenteric ischemia among critically ill ventilated patients with shock: a post hoc analysis of the NUTRIREA2 trial – Intensive Care Medicine

Health-related quality of life of COVID-19 two and 12 months after intensive care unit admission – Annals of Intensive Care

High levels of monocytic myeloid-derived suppressor cells are associated with favorable outcome in patients with pneumonia and sepsis with multi-organ failure – Intensive Care Medicine Experimental

Impact of platelet transfusion on outcomes in trauma patients – Critical Care

Increased 30-day mortality in very old ICU patients with COVID-19 compared to patients with respiratory failure without COVID-19 – Intensive Care Medicine

Intensive care nurses’ experiences using volatile anaesthetics in the intensive care unit: An exploratory study – Intensive and Critical Care Nursing

Intensive care unit visiting using virtual technology: Barriers, solutions, and opportunities – Intensive and Critical Care Nursing

Lung Ultrasound and Electrical Impedance Tomography During Ventilator-Induced Lung Injury – Critical Care Medicine

Neurologic Outcomes of Survivors of COVID-19–Associated Acute Respiratory Distress Syndrome Requiring Intubation – Critical Care Medicine

Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to the ICU: a multicenter observational retrospective study – Critical Care

Practices in sedation, analgesia, mobilization, delirium, and sleep deprivation in adult intensive care units (SAMDS-ICU): an international survey before and during the COVID-19 pandemic – Annals of Intensive Care

Quality Improvement Report Implementing a systematic care pathway for management of dysphagia after cardiothoracic surgery – Intensive and Critical Care Nursing

Relationship between time of emergency department admission and adherence to the Surviving Sepsis Campaign bundle in patients with septic shock – Critical Care

Relative Hypoglycemia and Lower Hemoglobin A1c-Adjusted Time in Band Are Strongly Associated With Increased Mortality in Critically Ill Patients – Critical Care Medicine

Sepsis hospitalization and risk of subsequent cardiovascular events in adults: a population-based matched cohort study – Intensive Care Medicine

Sequential lateral positioning as a new lung recruitment maneuver: an exploratory study in early mechanically ventilated Covid-19 ARDS patients – Annals of Intensive Care

Ten questions ICU specialists should address when managing cardiogenic acute pulmonary oedema – Intensive Care Medicine

The Effect of Clusters of Double Triggering and Ineffective Efforts in Critically Ill Patients – Critical Care Medicine

The effects of pantoprazole vs. placebo on 1-year outcomes, resource use and employment status in ICU patients at risk for gastrointestinal bleeding: a secondary analysis of the SUP-ICU trial – Intensive Care Medicine

The influence of timing of coronary angiography on acute kidney injury in out-of-hospital cardiac arrest patients: a retrospective cohort study – Annals of Intensive Care

The role of cell-free hemoglobin and haptoglobin in acute kidney injury in critically ill adults with ARDS and therapy with VV ECMO – Critical Care

Unreliable pulse oximetry in dark-skin patients: a plea for algorithm disclosure – Annals of Intensive Care

Very long-term survivors of in-hospital and out-of-hospital cardiac arrest show considerable impairment of daily life – Resuscitation


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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