Critical Care Evidence Updates – February 2022
Randomised Controlled Trials
Cuff Leak Test and Airway Obstruction in Mechanically Ventilated Intensive Care Unit Patients: A Pilot Randomized Controlled Clinical Trial – Annals of the American Thoracic Society
Early metabolic support for critically ill trauma patients: A prospective randomized controlled trial – The Journal of Trauma and Acute Care Surgery
Effect of Interleukin-6 Receptor Antagonists in Critically Ill Adult Patients with COVID-19 Pneumonia: two Randomised Controlled Trials of the CORIMUNO-19 Collaborative Group – European Respiratory Journal
Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial – Intensive Care Medicine
Efficacy and safety of baricitinib plus standard of care for the treatment of critically ill hospitalised adults with COVID-19 on invasive mechanical ventilation or extracorporeal membrane oxygenation: an exploratory, randomised, placebo-controlled trial – The Lancet Respiratory Medicine
Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities – The I-TECH Randomized Clinical Trial – JAMA Internal Medicine
Lung- and Diaphragm-Protective Ventilation by Titrating Inspiratory Support to Diaphragm Effort: A Randomized Clinical Trial – Critical Care Medicine
Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial – Intensive Care Medicine
Therapeutic Hyperthermia Is Associated With Improved Survival in Afebrile Critically Ill Patients With Sepsis – A Pilot Randomized Trial – Critical Care Medicine
Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial – Critical Care
NICE
COVID-19 rapid guideline: managing COVID-19 NG191
EarlyCDT Lung for assessing risk of lung cancer in solid lung nodules – guidance (DG46)
Other Guidance/Reports
Acute-on-Chronic Liver Failure Clinical Guidelines – American College of Gastroenterology
Guidance on Pin Site Care (PDF) – Royal College of Nursing
Cochrane
Primary Research
A qualitative exploration of nurse-physician collaboration in intensive care units -Intensive and Critical Care Nursing
Association of Metformin Use During Hospitalization and Mortality in Critically Ill Adults With Type 2 Diabetes Mellitus and Sepsis – Critical Care Medicine
Association of ventilator type with hospital mortality in critically ill patients with SARS-CoV2 infection: a prospective study – Annals of Intensive Care
Bedside post-pyloric tube placement using direct visualisation in mechanically ventilated patients: A single centre case series – Intensive and Critical Care Nursing
Burden of care related to monitoring patient vital signs during intensive care; a descriptive retrospective database study – Intensive and Critical Care Nursing
Cell cycle arrest biomarkers for predicting renal recovery from acute kidney injury: a prospective validation study – Annals of Intensive Care
Detection of cerebral hypoperfusion with a dynamic hyperoxia test using brain oxygenation pressure monitoring – Critical Care
Factors associated with acute mesenteric ischemia among critically ill ventilated patients with shock: a post hoc analysis of the NUTRIREA2 trial – Intensive Care Medicine
Health-related quality of life of COVID-19 two and 12 months after intensive care unit admission – Annals of Intensive Care
High levels of monocytic myeloid-derived suppressor cells are associated with favorable outcome in patients with pneumonia and sepsis with multi-organ failure – Intensive Care Medicine Experimental
Impact of platelet transfusion on outcomes in trauma patients – Critical Care
Increased 30-day mortality in very old ICU patients with COVID-19 compared to patients with respiratory failure without COVID-19 – Intensive Care Medicine
Intensive care nurses’ experiences using volatile anaesthetics in the intensive care unit: An exploratory study – Intensive and Critical Care Nursing
Intensive care unit visiting using virtual technology: Barriers, solutions, and opportunities – Intensive and Critical Care Nursing
Lung Ultrasound and Electrical Impedance Tomography During Ventilator-Induced Lung Injury – Critical Care Medicine
Neurologic Outcomes of Survivors of COVID-19–Associated Acute Respiratory Distress Syndrome Requiring Intubation – Critical Care Medicine
Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to the ICU: a multicenter observational retrospective study – Critical Care
Practices in sedation, analgesia, mobilization, delirium, and sleep deprivation in adult intensive care units (SAMDS-ICU): an international survey before and during the COVID-19 pandemic – Annals of Intensive Care
Quality Improvement Report Implementing a systematic care pathway for management of dysphagia after cardiothoracic surgery – Intensive and Critical Care Nursing
Relationship between time of emergency department admission and adherence to the Surviving Sepsis Campaign bundle in patients with septic shock – Critical Care
Relative Hypoglycemia and Lower Hemoglobin A1c-Adjusted Time in Band Are Strongly Associated With Increased Mortality in Critically Ill Patients – Critical Care Medicine
Sepsis hospitalization and risk of subsequent cardiovascular events in adults: a population-based matched cohort study – Intensive Care Medicine
Sequential lateral positioning as a new lung recruitment maneuver: an exploratory study in early mechanically ventilated Covid-19 ARDS patients – Annals of Intensive Care
Ten questions ICU specialists should address when managing cardiogenic acute pulmonary oedema – Intensive Care Medicine
The Effect of Clusters of Double Triggering and Ineffective Efforts in Critically Ill Patients – Critical Care Medicine
The effects of pantoprazole vs. placebo on 1-year outcomes, resource use and employment status in ICU patients at risk for gastrointestinal bleeding: a secondary analysis of the SUP-ICU trial – Intensive Care Medicine
The influence of timing of coronary angiography on acute kidney injury in out-of-hospital cardiac arrest patients: a retrospective cohort study – Annals of Intensive Care
The role of cell-free hemoglobin and haptoglobin in acute kidney injury in critically ill adults with ARDS and therapy with VV ECMO – Critical Care
Unreliable pulse oximetry in dark-skin patients: a plea for algorithm disclosure – Annals of Intensive Care
Very long-term survivors of in-hospital and out-of-hospital cardiac arrest show considerable impairment of daily life – Resuscitation
Metadata
Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash
