Critical Care Evidence Updates – February 2023

Randomised Controlled Trials

A randomized, double-blind trial comparing the effect of two blood pressure targets on global brain metabolism after out-of-hospital cardiac arrest  Critical Care

BIS-guided sedation prevents the cough reaction of patients under general anaesthesia caused by extubation: a randomized controlled trial  Journal of Anesthesia, Analgesia and Critical Care

Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension  NEJM

Fluid balance control in critically ill patients: results from POINCARE-2 stepped wedge cluster-randomized trial  Critical Care

FLUID trial: a hospital-wide open-label cluster cross-over pragmatic comparative effectiveness randomised pilot trial comparing normal saline to Ringer’s lactate  BMJ Open

Hypothermia or Machine Perfusion in Kidney Donors  NEJM

Inhaled prostacyclin therapy in the acute respiratory distress syndrome: a randomized controlled multicenter trial  Respiratory Research

Long-term outcomes of patients with COVID-19 treated with helmet noninvasive ventilation or usual respiratory support: follow-up study of the Helmet-COVID randomized clinical trial  Intensive Care Medicine

Outcomes in participants with ventilated nosocomial pneumonia and organ failure treated with ceftolozane/tazobactam versus meropenem: a subset analysis of the phase 3, randomized, controlled ASPECT-NP trial  Annals of Intensive Care

Postoperative Supplemental Oxygen in Liver Transplantation (PSOLT) does not reduce the rate of infections: results of a randomized controlled trial  BMC Medicine

Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial  The Lancet

The low-dose colchicine in patients after non-CABG cardiac surgery: a randomized controlled trial  Critical Care


Urinary tract infections in adults QS90

Other Guidance/Reports

Anesthetic Care of the Pregnant Patient With Cardiovascular Disease: A Scientific Statement From the American Heart Association  Circulation

Complement activation in severely ill patients with sepsis: no relationship with inflammation and disease severity  Critical Care

Incidence of near-death experiences in patients surviving a prolonged critical illness and their long-term impact: a prospective observational study  Critical Care

Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup  Nature Reviews Nephrology

The care of transgender patients in critical care: A call to action  The Journal of the Intensive Care Society

The International Society for Heart and Lung Transplantation/Heart Failure Society of America Guideline on Acute Mechanical Circulatory Support  The Journal of Heart and Lung Transplantation

Impact of renal replacement therapy strategy on beta-lactam plasma concentrations: the BETAKIKI study—an ancillary study of a randomized controlled trial  Annals of Intensive Care

Primary Research

A Decision Guide for Assessing the Recently Extubated Patient’s Readiness for Safe Oral Intake  Critical Care Nurse

A Propensity-Matched Cohort Assessing Impact of a Neutralizing Monoclonal Antibody in Mild-to-Moderate Coronavirus Disease 2019  Journal of Intensive Care Medicine

A simple mortality prediction model for sepsis patients in intensive care  Journal of the Intensive Care Society

Age Moderates the Effect of Obesity on Mortality Risk in Critically Ill Patients With COVID-19: A Nationwide Observational Cohort Study  Critical Care Medicine

Agitated Saline Contrast Injection in Patients with Severe Hypoxemia  Journal of Intensive Care Medicine

An international survey exploring the adoption and utility of diagnostic lung ultrasound by physiotherapists and respiratory therapists in intensive care  Journal of the Intensive Care Society

Antimicrobial residual drug error in the intensive care unit; a single blinded prospective observational study  Intensive and Critical Care Nursing

Association between histamine 2 receptor antagonists and sepsis outcomes in ICU patients: a retrospective analysis using the MIMI-IV database  Journal of Anesthesia, Analgesia and Critical Care

Association Between Preexisting Mental Health Disorders and Adverse Outcomes in Adult Intensive Care Patients: A Data Linkage Study  Critical Care Medicine

Association of systolic, diastolic, mean, and pulse pressure with morbidity and mortality in septic ICU patients: a nationwide observational study  Annals of Intensive Care

COVID-19 does not influence functional status after ARDS therapy  Critical Care

Critically ill patient mortality by age: long-term follow-up (CIMbA-LT)  Annals of Intensive Care

Deep Learning–Based Recurrent Delirium Prediction in Critically Ill Patients  Critical Care Medicine

Determinants of Mortality for Ventilated Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia  Critical Care Explorations

Determination of microbial contamination on the outer surface of needleless connectors before and after disinfection  Intensive and Critical Care Nursing

Development and External Validation of a Prediction Model for Quality of Life of ICU Survivors: A Subanalysis of the MONITOR-IC Prospective Cohort Study  Critical Care Medicine

Effectiveness of systemic thrombolysis on clinical outcomes in high-risk pulmonary embolism patients with venoarterial extracorporeal membrane oxygenation: a nationwide inpatient database study  Journal of Intensive Care

Electroencephalography for prognostication of outcome in adults with severe herpes simplex encephalitis  Annals of Intensive Care

Epidemiology, clinical presentation, and outcomes of 620 patients with eosinophilia in the intensive care unit  Intensive Care Medicine

Excess mortality among non-COVID-19 surgical patients attributable to the exposure of French intensive and intermediate care units to the pandemic  Intensive Care Medicine

Extracorporeal Membrane Oxygenation for COVID-19: Comparison of Outcomes to Non-COVID-19–Related Viral Acute Respiratory Distress Syndrome From the Extracorporeal Life Support Organization Registry  Critical Care Explorations

Five new realities in critical care for patients with cancer  Intensive Care Medicine

Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19  Critical Care

Health-Related Quality of Life of COVID-19 Survivors Treated in Intensive Care Unit—Prospective Observational Study    Journal of Intensive Care Medicine

Hemodynamic impact of prone position. Let’s protect the lung and its circulation to improve prognosis  Intensive Care Medicine

Hemorrhage, Disseminated Intravascular Coagulopathy, and Thrombosis Complications Among Critically Ill Patients with COVID-19: An International COVID-19 Critical Care Consortium Study  Critical Care Medicine

How to manage coagulopathies in critically ill patients  Intensive Care Medicine

ICU patients with infectious complications after abdominopelvic surgery: Is thoracic CT in addition to abdominal CT helpful?  Annals of Intensive Care

Influence of Deep Sedation in Intensive Care Medicine Memories of Critical COVID-19 Survivors  Journal of Intensive Care Medicine

Inhaled amikacin for pneumonia treatment and dissemination prevention: an experimental model of severe monolateral Pseudomonas aeruginosa pneumonia  Critical Care

Intensive Care Unit Diaries: A Nurse-Led Program  Critical Care Nurse

Intestinal injury in cardiac arrest is associated with multiple organ dysfunction: A prospective cohort study  Resuscitation

Intravenous methylprednisolone pulse therapy and the risk of in-hospital mortality among acute COVID-19 patients: Nationwide clinical cohort study  Critical Care

Levosimendan in patients undergoing extracorporeal membrane oxygenation after cardiac surgery: an emulated target trial using observational data  Critical Care

Lung morphology impacts the association between ventilatory variables and mortality in patients with acute respiratory distress syndrome  Critical Care

Myoclonus in comatose patients with electrographic status epilepticus after cardiac arrest: Corresponding EEG patterns, effects of treatment and outcomes  Resuscitation

Obesity Paradox and Functional Outcomes in Sepsis: A Multicenter Prospective Study  Critical Care Medicine

Occurrence Rate and Outcomes of Weaning Groups According to a Refined Weaning Classification: A Retrospective Observational Study  Critical Care Medicine

One-Year Functional Outcomes After Invasive Mechanical Ventilation for Older Adults With Preexisting Long-Term Care-Needs  Critical Care Medicine

Oxygenation thresholds for invasive ventilation in hypoxemic respiratory failure: a target trial emulation in two cohorts  Critical Care

Plasma neurofilament light is a predictor of neurological outcome 12 h after cardiac arrest  Critical Care

Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study  Critical Care

Precision of CT-derived alveolar recruitment assessed by human observers and a machine learning algorithm in moderate and severe ARDS  Intensive Care Medicine Experimental

Predictive value of soluble CD59 for poor 28-day neurological prognosis and all-cause mortality in patients after cardiopulmonary resuscitation: a prospective observatory study  Journal of Intensive Care

Prevalence of long-term decision regret and associated risk factors in a large cohort of ICU surrogate decision makers  Critical Care

Quantifying Critical Care Pharmacist Interventions in COVID-19  Journal of Intensive Care Medicine

Racial Disparities in Documented Chief Complaints and Diagnoses in Sepsis Patients  Journal of Intensive Care Medicine

Rehabilitation in the intensive care unit: Where are we and what are we aiming for?  Intensive and Critical Care Nursing

Risk Factors for Major Cardiovascular Events in Adult Sepsis Survivors: A Population-Based Cohort Study  Critical Care Medicine

Same but Different—ECMO in COVID-19 and ARDS of Other Etiologies. Comparison of Survival Outcomes and Management in Different ARDS Groups   Journal of Intensive Care Medicine

Severe community-acquired Streptococcus pneumoniae bacterial meningitis: clinical and prognostic picture from the intensive care unit  Critical Care

Telehealth in the intensive care unit: Current insights and future directions  Intensive and Critical Care Nursing

The association between time of in hospital cardiac arrest and mortality; a retrospective analysis of two UK databases  Resuscitation

The end-tidal alveolar dead space fraction for risk stratification during the first week of invasive mechanical ventilation: an observational cohort study  Critical Care


Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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