Critical Care Evidence Updates – September 2022

Randomised Controlled Trials

A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries  NEJM

A Randomized Trial of Mesenchymal Stromal Cells for Moderate to Severe ARDS From COVID-19  American Journal of Respiratory and Critical Care Medicine

Abbreviated Antiplatelet Therapy After Coronary Stenting in Patients With Myocardial Infarction at High Bleeding Risk  Journal of the American College of Cardiology

Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis  NEJM

Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial  The Lancet Respiratory Medicine

Applying bio-impedance vector analysis (BIVA) to adjust ultrafiltration rate in critically ill patients on continuous renal replacement therapy: A randomized controlled trial  Journal of Critical Care

Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trial  Intensive Care Medicine

Dietary nitrate supplementation to enhance exercise capacity in hypoxic COPD: EDEN-OX, a double-blind, placebo-controlled, randomised cross-over study  Thorax

Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial  The Lancet Respiratory Medicine

Discomfort improvement for critically ill patients using electronic relaxation devices: results of the cross-over randomized controlled trial E-CHOISIR (Electronic-CHOIce of a System for Intensive care Relaxation)  Critical Care

Early administration of hydrocortisone, vitamin C, and thiamine in adult patients with septic shock: a randomized controlled clinical trial  Critical Care

Effect of Clinical Decision Support With Audit and Feedback on Prevention of Acute Kidney Injury in Patients Undergoing Coronary Angiography – A Randomized Clinical Trial  JAMA

Effect of Hemadsorption Therapy in Critically Ill Patients with COVID-19 (CYTOCOV-19): A Prospective Randomized Controlled Pilot Trial  Blood Purification

Effect of Helmet Noninvasive Ventilation vs Usual Respiratory Support on Mortality Among Patients With Acute Hypoxemic Respiratory Failure Due to COVID-19 – The HELMET-COVID Randomized Clinical Trial  JAMA

Effect of High-Flow Nasal Cannula Oxygen vs Standard Oxygen Therapy on Mortality in Patients With Respiratory Failure Due to COVID-19 – The SOHO-COVID Randomized Clinical Trial  JAMA

Effect of intravenous almitrine on intubation or mortality in patients with COVID-19 acute hypoxemic respiratory failure: A multicentre, randomised, double-blind, placebo-controlled trial  eClinicalMedicine

Effect of ventilation mode on postoperative pulmonary complications following lung resection surgery: a randomised controlled trial  Anaesthesia

Effects of Nicorandil Administration on Infarct Size in Patients With ST‐Segment–Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: The CHANGE Trial  Journal of the American Heart Association

Impact of a Nurse-Driven Patient Empowerment Intervention on the Reduction in Patients’ Anxiety and Depression During ICU Discharge: A Randomized Clinical Trial  Critical Care Medicine

Molecular point-of-care testing for lower respiratory tract pathogens improves safe antibiotic de-escalation in patients with pneumonia in the ICU: Results of a randomised controlled trial  Journal of Infection

Operative vs Nonoperative Treatment of Acute Unstable Chest Wall Injuries – A Randomized Clinical Trial  JAMA Surgery

Remote ischemic conditioning in septic shock: the RECO-Sepsis randomized clinical trial  Intensive Care Medicine

Right dose, right now: bedside, real-time, data-driven, and personalised antibiotic dosing in critically ill patients with sepsis or septic shock—a two-centre randomised clinical trial  Critical Care

Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study  The Lancet Respiratory Medicine

Standard and flexible tip bougie for tracheal intubation using a non-channelled hyperangulated videolaryngoscope: a randomised comparison  Anaesthesia

Temperature Control After In-Hospital Cardiac Arrest: A Randomized Clinical Trial  Circulation

Other Guidance/Reports

AGA Clinical Practice Update on the Evaluation and Management of Acute Kidney Injury in Patients With Cirrhosis: Expert Review  Clinical Gastroenterology and Hepatology

Artificial liver support in patients with liver failure: a modified DELPHI consensus of international experts  Intensive Care Medicine

Clinical nutrition issues in 2022: What is missing to trust supplemental parenteral nutrition (SPN) in ICU patients?  Critical Care

Clinical Practice Guidelines From the Association for the Advancement of Blood and Biotherapies (AABB): COVID-19 Convalescent Plasma  Annals of Internal Medicine

Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19  Clinical Infectious Diseases

Joint British Society consensus recommendations for magnetic resonance imaging for patients with cardiac implantable electronic devices  Heart

Laryngeal injury following endotracheal intubation: Have you considered reflux?  Anaesthesia and Intensive Care

Management of Patients at Risk for and With Left Ventricular Thrombus: A Scientific Statement From the American Heart Association  Circulation

Palliative Care Early in the Care Continuum among Patients with Serious Respiratory Illness: An Official ATS/AAHPM/HPNA/SWHPN Policy Statement  American Journal of Respiratory and Critical Care Medicine

Postoperative pain management in non-traumatic emergency general surgery: WSES-GAIS-SIAARTI-AAST guidelines  World Journal of Emergency Surgery

The Australasian ANZSCTS/ANZICS guidelines on cardiothoracic advanced life support (CALS-ANZ)  Critical Care and Resuscitation


Chest physiotherapy for pneumonia in adults

Interventions for increasing immunosuppressant medication adherence in solid organ transplant recipients

Primary Research

A novel capnogram analysis to guide ventilation during cardiopulmonary resuscitation: clinical and experimental observations  Critical Care

Adverse events, short- and long-term outcomes of extra corporeal liver therapy in the intensive care unit: 16 years experience with MARS® in a single center  Critical Care

Assessing oral comprehension with an eye tracking based innovative device in critically ill patients and healthy volunteers: a cohort study  Critical Care

Association between ICU admission during off-hours and in-hospital mortality: a multicenter registry in Japan  Journal of Intensive Care

Augmented renal clearance in the ICU: estimation, incidence, risk factors and consequences—a retrospective observational study  Annals of Intensive Care

Benefit with preventive noninvasive ventilation in subgroups of patients at high-risk for reintubation: a post hoc analysis  Journal of Intensive Care

Cardiorespiratory Fitness and Neuromuscular Function of Mechanically Ventilated ICU COVID-19 Patients  Critical Care Medicine

Chest wall loading during supine and prone position in patients with COVID-19 ARDS: effects on respiratory mechanics and gas exchange  Critical Care

Circulating and urinary microRNAs profile for predicting renal recovery from severe acute kidney injury  Annals of Intensive Care

Clustering analysis of geriatric and acute characteristics in a cohort of very old patients on admission to ICU  Intensive Care Medicine

Critical care hepatology: definitions, incidence, prognosis and role of liver failure in critically ill patients  Critical Care

Decreased renal cortical perfusion, independent of changes in renal blood flow and sublingual microcirculatory impairment, is associated with the severity of acute kidney injury in patients with septic shock  Critical Care

Determinants of change in code status among patients with cardiopulmonary arrest admitted to the intensive care unit  Resuscitation

Development and validation of an early warning model for hospitalized COVID-19 patients: a multi-center retrospective cohort study  Intensive Care Medicine Experimental

Development and validation of novel sepsis subphenotypes using trajectories of vital signs  Intensive Care Medicine

Early antibiotic therapy is associated with a lower probability of successful liberation from mechanical ventilation in patients with severe acute exacerbation of chronic obstructive pulmonary disease  Annals of Intensive Care

Effects of Preconditioning on RBC Deformability in Critically Ill Patients  Critical Care Explorations

Evaluation of the Diagnostic Value of Cell Population Data in Sepsis in Comparison to Localized Infection, Chronic Inflammation, and Noninfectious Inflammation Cases  Journal of Intensive Care Medicine

Factors Influencing Engagement with in-Person Intensive Care Unit Recovery Clinic Services  Journal of Intensive Care Medicine

Herpesviridae lung reactivation and infection in patients with severe COVID-19 or influenza virus pneumonia: a comparative study  Annals of Intensive Care

Host Gene Expression to Predict Sepsis Progression  Critical Care Medicine

Impact on Blood Product Utilization with Thromboelastography Guided Resuscitation for Gastrointestinal Hemorrhage  Journal of Intensive Care Medicine

Increased Endotoxin Activity in COVID-19 Patients Admitted to the Intensive Care Unit  Journal of Intensive Care Medicine

Modulation of the Association Between Age and Death by Risk Factor Burden in Critically Ill Patients With COVID-19  Critical Care Explorations

Mortality of patients with hospital-onset sepsis in hospitals with all-day and non-all-day rapid response teams: a prospective nationwide multicenter cohort study  Critical Care

MRI of Cerebrovascular Injury Associated With COVID-19 and Non-COVID-19 Acute Respiratory Distress Syndrome: A Matched Case-Control Study  Critical Care Medicine

Multiple-site decontamination regimen decreases acquired infection incidence in mechanically ventilated COVID-19 patients  Annals of Intensive Care

Myocardial effects of angiotensin II compared to norepinephrine in an animal model of septic shock  Critical Care

Novel Technology Deployed for Remote Ventilator Management by Respiratory Therapists During the COVID-19 Pandemic: Lessons Learned  Journal of Intensive Care Medicine

Obesity and critical care nutrition: current practice gaps and directions for future research  Critical Care

Oral midodrine does not expedite liberation from protracted vasopressor infusions: A case-control study  Anaesthesia and Intensive Care

PEEP-FiO2 table versus EIT to titrate PEEP in mechanically ventilated patients with COVID-19-related ARDS  Critical Care

Pharmacokinetics, efficacy and tolerance of cefoxitin in the treatment of cefoxitin-susceptible extended-spectrum beta-lactamase producing Enterobacterales infections in critically ill patients: a retrospective single-center study  Annals of Intensive Care

Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19  Critical Care

Prediction of Inhospital Mortality in Critically Ill Patients With Sepsis: Confirmation of the Added Value of 24-Hour Lactate to Acute Physiology and Chronic Health Evaluation IV  Critical Care Explorations

Presence of Antibodies to Severe Acute Respiratory Syndrome Coronavirus-2 on Admission Is Associated With Decreased Mortality in COVID-19 Critical Illness  Critical Care Explorations

Prevalence and impact of early prone position on 30-day mortality in mechanically ventilated patients with COVID-19: a nationwide cohort study  Critical Care

Prevalence and Impact of Infection during Extracorporeal Membrane Oxygenation in Oncologic Patients: A Retrospective Analysis of the Extracorporeal Life Support Organization (ELSO) Registry  Journal of Intensive Care Medicine

Pulse Oximetry and Race in Critically Ill Adults  Critical Care Explorations

Relationship between corticosteroid use and incidence of ventilator-associated pneumonia in COVID-19 patients: a retrospective multicenter study  Critical Care

Remimazolam besylate versus propofol for long-term sedation during invasive mechanical ventilation: a pilot study  Critical Care

Renal outcomes according to renal replacement therapy modality and treatment protocol in the ATN and RENAL trials  Critical Care

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study  Critical Care

Scoping review on diagnostic criteria and investigative approach in sepsis of unknown origin in critically ill patients  Journal of Intensive Care

Serum Anion Gap Level Predicts All-Cause Mortality in Septic Patients: A Retrospective Study Based on the MIMIC III Database  Journal of Intensive Care Medicine

Small wards in the ICU: a favorable measure for controlling the transmission of carbapenem-resistant Klebsiella pneumoniae  Intensive Care Medicine

Sudden Decompensation of Patients Admitted to Non-ICU Settings Within 24 h of Emergency Department Admission  Journal of Intensive Care Medicine

The prognostic value of early measures of the ventilatory ratio in the ARDS ROSE trial  Critical Care

Vasopressin Response and Clinical Trajectory in Septic Shock Patients  Journal of Intensive Care Medicine

Validation of the flow index to detect low inspiratory effort during pressure support ventilation  Annals of Intensive Care



Summary author: Rebecca Howes @ClinicalLibsPHU
Summary date:
Picture by: Ehimetalor Akhere Unuabona on Unsplash

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