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Does intravenous vitamin C, hydrocortisone and thiamine in addition to standard treatment, improve mortality in ICU patients with severe sepsis or septic shock, compared with standard treatment alone?
Continue reading »A compendium of critical appraisals in Intensive Care Medicine research and related specialties
A collection of TBL summaries relevant to Intensive Care Medicine
Does intravenous vitamin C, hydrocortisone and thiamine in addition to standard treatment, improve mortality in ICU patients with severe sepsis or septic shock, compared with standard treatment alone?
Continue reading »In hospitalised patients with community-acquired pneumonia (CAP), is five days of antibiotic therapy non-inferior to standard practice with respect to clinical improvement?
Continue reading »In patients with convulsive status epilepticus, does the addition of therapeutic hypothermia to standard care improve neurological outcomes?
Continue reading »In elderly patients following non-cardiac surgery, does a low dose dexmedetomidine infusion, compared with placebo, decrease the incidence of delirium?
Continue reading »In critically ill adults requiring renal replacement therapy, does higher intensity dialysis compared to lower intensity dialysis reduce mortality?
Continue reading »In critically ill patients who are anaemic, does early administration of intravenous iron compared to placebo reduce the requirement for blood transfusion?
Continue reading »In medically-qualified anaesthetist, does the use of the transverse ultrasound technique compared to the longitudinal orientation result in faster identification of the cricothyroid membrane?
Continue reading »In patients undergoing internal jugular cannulation under ultrasound guidance, does the use of an oblique compared to short- and long-axis approach increase success rate and decrease complications?
Continue reading »In patients with septic shock who are mechanically ventilated does indexed LV end-diastolic area and respiratory changes in aortic blood velocity predict the haemodynamic effects of volume expansion?
Continue reading »In mechanically ventilated patients with subarachnoid hemorrhage (SAH), does the distensibility of IVC on ultrasound, predict fluid responsiveness measured by thermodilution?
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