A compendium of critical appraisals in Intensive Care Medicine research and related specialties
A collection of TBL summaries relevant to Intensive Care Medicine
In patients undergoing major abdominal surgery who are at high nutritional risk and have poor tolerance to enteral nutrition (EN) does the early use of supplemental parental nutrition (E-SPN), compared with late supplemental parental nutrition (L-SPN), reduce the risk of nosocomial infection?
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Diuretics Versus Volume Expansion in the Initial Management of Acute Intermediate High‐Risk Pulmonary Embolism Ferrari E. Lung (2022); DOI:10.1007/s00408-022-00530-5 Clinical Question In adult patients with acute pulmonary embolism and right heart strain does a strategy of volume expansion or early diuretic therapy result in a more rapid resolution of troponin levels? Background Acute pulmonary embolism (PE) is a common cause […]
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In adult patients in ICU with septic shock, does a restrictive approach to fluid therapy compared to a standard care result in fewer deaths at day 90?
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In patients with cardiogenic shock receiving venoarterial extracorporeal membrane oxygenation(VA-ECMO), does early use of moderate hypothermia (33-34°C) compared with strict normothermia (36-37 °C) improve 30 day mortality?
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In patients requiring rapid sequence intubation (RSI) in the emergency department does the addition of fentanyl to ketamine and rocuronium reduce the frequency of patients having a systolic blood pressure (SBP) outside of a target range of 100-150mmHg?
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In patients with severe stroke does early (≤5 days of intubation) tracheostomy when compared to standard timing (from day 10) of tracheostomy improve functional outcome at 6 months?
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In patients with large cerebral infarction volumes does the use of endovascular therapy alongside medical care compared with medical care alone improve 90-day functional outcomes?
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In neonates undergoing elective endotracheal intubation, does nasal high-flow therapy compared with standard care, improve 1st pass success without physiological instability?
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In patients admitted to ICU with severe diffuse traumatic brain injury (TBI) and refractory raised intracranial pressure (ICP), does early decompressive craniectomy improve functional outcomes when compared with continued medical management?
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In patients with trauma-related haemorrhagic shock does prehospital administration of packed red cells and lyophilised plasma (Lyo-Plas) compared with normal saline reduce the composite outcome of mortality and failure to reach lactate clearance?
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