SuDDICU
In mechanically ventilated adults, does the addition of selective decontamination of the digestive tract (SDD) compared to standard care reduce all-cause hospital mortality within 90 days?
Continue reading »Category: Intensive Care Medicine
A collection of TBL summaries relevant to Intensive Care Medicine
DOSEVF
In patients with refractory VF, does Double Sequential External Defibrillation or Vector-change Defibrillation improve survival to hospital discharge?
Continue reading »BOX (Oxygen)
In comatose patients following cardiac arrest does a restrictive compared with a liberal oxygenation strategy, reduce death or survival at discharge with a poor neurological outcome?
Continue reading »BOX Trial: Blood Pressure
Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest Kjaergaard et al | New England Journal of Medicine| August 2022 DOI: 10.1056/NEJMoa2208687 Clinical Question In patients with return of spontaneous circulation (ROSC) after cardiac arrest does a higher MAP target (> 77mmHg) compared to a standard target (>63mmHg) reduce death or survival at discharge with a poor neurological status? Background Manipulation […]
Continue reading »Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis
In adults with acute pancreatitis does aggressive fluid resuscitation compared to moderate resuscitation result in a reduction in the development of moderately severe or severe pancreatitis?
Continue reading »LOVIT Trial
In adult patients with sepsis receiving vasopressor therapy, does a high dose of vitamin C in comparison to placebo, reduce the risk of death or persistent organ dysfunction at 28 days?
Continue reading »CandiSep
In septic adults at high risk for invasive candida infection (ICI) does the use (1,3)-β-D-glucan (BDG) guided antifungal strategy, compared with standard treatment, reduce 28-day mortality compared to standard care?
Continue reading »Supplemental Parental Nutrition and Abdominal Surgery
In patients undergoing major abdominal surgery who are at high nutritional risk and have poor tolerance to enteral nutrition (EN) does the early use of supplemental parental nutrition (E-SPN), compared with late supplemental parental nutrition (L-SPN), reduce the risk of nosocomial infection?
Continue reading »Ferrari
Diuretics Versus Volume Expansion in the Initial Management of Acute Intermediate High‐Risk Pulmonary Embolism Ferrari E. Lung (2022); DOI:10.1007/s00408-022-00530-5 Clinical Question In adult patients with acute pulmonary embolism and right heart strain does a strategy of volume expansion or early diuretic therapy result in a more rapid resolution of troponin levels? Background Acute pulmonary embolism (PE) is a common cause […]
Continue reading »Classic Trial
In adult patients in ICU with septic shock, does a restrictive approach to fluid therapy compared to a standard care result in fewer deaths at day 90?
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